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- K252a abstract "K252a is an alkaloid isolated from Nocardiopisis sp. soil fungi. This staurosporine analog is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase (IC50 = 1.8 and 1.7 nmol/L, respectively). At higher concentrations it is also an efficient inhibitor of serine/threonine protein kinases (IC50 of 10 to 30 nmol/L).K252a is reported to promote myogenic differentiation in C2 mouse myoblasts and has been shown to block the neuronal differentiation of rat pheochromocytoma PC12 cells by inhibition of trk tyrosine kinase activity.K252a has been reported in preclinical research as a potential treatment for psoriasis.K252a inhibits tyrosine phosphorylation of Trk A induced by NGF. PC12 cells were incubated in the presence or absence of 10 ng/ml NGF with or without various concentrations of K252a.".
- K252a iupacName "(9S-(9α,10β,12α))-2,3,9,10,11,12-hexahydro-10-hydroxy-10-(methoxycarbonyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one".
- K252a thumbnail (+)-K252a.svg?width=300.
- K252a wikiPageID "4080976".
- K252a wikiPageLength "3668".
- K252a wikiPageOutDegree "20".
- K252a wikiPageRevisionID "698844376".
- K252a wikiPageWikiLink ANA-12.
- K252a wikiPageWikiLink Alkaloid.
- K252a wikiPageWikiLink Category:Alkaloids.
- K252a wikiPageWikiLink Category:Indolocarbazoles.
- K252a wikiPageWikiLink Category:Lactams.
- K252a wikiPageWikiLink Category:Protein_kinase_inhibitors.
- K252a wikiPageWikiLink Category:TrkB_antagonists.
- K252a wikiPageWikiLink Cyclotraxin_B.
- K252a wikiPageWikiLink Dichloromethane.
- K252a wikiPageWikiLink Dimethyl_sulfoxide.
- K252a wikiPageWikiLink Enzyme_inhibitor.
- K252a wikiPageWikiLink Kinase.
- K252a wikiPageWikiLink Litre.
- K252a wikiPageWikiLink Methanol.
- K252a wikiPageWikiLink Mole_(unit).
- K252a wikiPageWikiLink Orders_of_magnitude_(mass).
- K252a wikiPageWikiLink Phosphorylation.
- K252a wikiPageWikiLink Psoriasis.
- K252a wikiPageWikiLink Staurosporine.
- K252a wikiPageWikiLink W:Journal_of_the_American_Chemical_Society.
- K252a wikiPageWikiLinkText "K252a".
- K252a imagefile "-K252a 1R0P.png".
- K252a imagefile "-K252a.svg".
- K252a iupacname "120.0".
- K252a verifiedfields "changed".
- K252a verifiedrevid "461783276".
- K252a watchedfields "changed".
- K252a wikiPageUsesTemplate Template:Biochem-stub.
- K252a wikiPageUsesTemplate Template:Cascite.
- K252a wikiPageUsesTemplate Template:Chembox.
- K252a wikiPageUsesTemplate Template:Chembox_Hazards.
- K252a wikiPageUsesTemplate Template:Chembox_Identifiers.
- K252a wikiPageUsesTemplate Template:Chembox_Properties.
- K252a wikiPageUsesTemplate Template:Chemspidercite.
- K252a wikiPageUsesTemplate Template:Citation_needed.
- K252a wikiPageUsesTemplate Template:Cite_journal.
- K252a wikiPageUsesTemplate Template:Ebicite.
- K252a wikiPageUsesTemplate Template:Fdacite.
- K252a wikiPageUsesTemplate Template:Neurotrophinergics.
- K252a wikiPageUsesTemplate Template:Reflist.
- K252a wikiPageUsesTemplate Template:Stdinchicite.
- K252a subject Category:Alkaloids.
- K252a subject Category:Indolocarbazoles.
- K252a subject Category:Lactams.
- K252a subject Category:Protein_kinase_inhibitors.
- K252a subject Category:TrkB_antagonists.
- K252a hypernym Alkaloid.
- K252a type Biomolecule.
- K252a type ChemicalCompound.
- K252a type ChemicalSubstance.
- K252a type Alkaloid.
- K252a type Amide.
- K252a type Biomolecule.
- K252a type Chemical.
- K252a type Heterocycle.
- K252a type Inhibitor.
- K252a type Lactam.
- K252a type Redirect.
- K252a type ChemicalObject.
- K252a type Thing.
- K252a type Q11173.
- K252a comment "K252a is an alkaloid isolated from Nocardiopisis sp. soil fungi. This staurosporine analog is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase (IC50 = 1.8 and 1.7 nmol/L, respectively).".
- K252a label "K252a".
- K252a sameAs Q5931064.
- K252a sameAs کی۲۵۲ای.
- K252a sameAs K252a.
- K252a sameAs m.0bh1fd.
- K252a sameAs K252a.
- K252a sameAs K252a.
- K252a sameAs Q5931064.
- K252a wasDerivedFrom K252a?oldid=698844376.
- K252a depiction (+)-K252a.svg.
- K252a isPrimaryTopicOf K252a.