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- John_W._Semple abstract "John W. Semple is a Canadian Scientist at St. Michael's Hospital and a Professor of Pharmacology at the University of Toronto. He was born in Windsor, Ontario in 1959 and received his PhD in Immunology at Queen's University at Kingston, Ontario. In 1991, Semple, along with John Freedman, discovered a T helper cell defect in patients with the bleeding disorder called immune thrombocytopenic purpura (ITP). ITP is the condition of having a low platelet count (thrombocytopenia) and most causes appear to be related to antibodies against platelets. Very low platelet counts can lead to a bleeding diathesis and purpura. The T cell defect was initially shown to be an exaggerated interleukin-2 response when T cells were cultured with platelets in vitro. Subsequently, this cytokine abnormality was shown by others to be responsible for many of the autoimmune mechanisms causing the disorder.).The importance of understanding the T cell defects in ITP is that novel therapies aimed at these cells may significantly benefit patients with ITP.".
- John_W._Semple birthDate "1959".
- John_W._Semple birthYear "1959".
- John_W._Semple wikiPageExternalLink profile.php?id=semple&navMenuID=6.2.0.0.0.
- John_W._Semple wikiPageExternalLink index.html.
- John_W._Semple wikiPageExternalLink semple.htm.
- John_W._Semple wikiPageID "10983360".
- John_W._Semple wikiPageLength "4160".
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- John_W._Semple wikiPageRevisionID "678934450".
- John_W._Semple wikiPageWikiLink Antibody.
- John_W._Semple wikiPageWikiLink Autoimmunity.
- John_W._Semple wikiPageWikiLink Category:1959_births.
- John_W._Semple wikiPageWikiLink Category:Canadian_immunologists.
- John_W._Semple wikiPageWikiLink Category:Canadian_medical_researchers.
- John_W._Semple wikiPageWikiLink Category:Canadian_scientists.
- John_W._Semple wikiPageWikiLink Category:Living_people.
- John_W._Semple wikiPageWikiLink Category:Medical_educators.
- John_W._Semple wikiPageWikiLink Category:University_of_Toronto_faculty.
- John_W._Semple wikiPageWikiLink Cytokine.
- John_W._Semple wikiPageWikiLink Interleukin_2.
- John_W._Semple wikiPageWikiLink Kingston,_Ontario.
- John_W._Semple wikiPageWikiLink Platelet.
- John_W._Semple wikiPageWikiLink Purpura.
- John_W._Semple wikiPageWikiLink Queens_University.
- John_W._Semple wikiPageWikiLink St._Michaels_Hospital_(Toronto).
- John_W._Semple wikiPageWikiLink T_helper_cell.
- John_W._Semple wikiPageWikiLink University_of_Toronto.
- John_W._Semple wikiPageWikiLink Windsor,_Ontario.
- John_W._Semple wikiPageWikiLinkText "John W. Semple".
- John_W._Semple dateOfBirth "1959".
- John_W._Semple name "Semple, John W.".
- John_W._Semple shortDescription "Canadian immunologist".
- John_W._Semple wikiPageUsesTemplate Template:Canada-med-bio-stub.
- John_W._Semple wikiPageUsesTemplate Template:Notability.
- John_W._Semple wikiPageUsesTemplate Template:Persondata.
- John_W._Semple wikiPageUsesTemplate Template:Reflist.
- John_W._Semple description "Canadian immunologist".
- John_W._Semple description "Canadian immunologist".
- John_W._Semple subject Category:1959_births.
- John_W._Semple subject Category:Canadian_immunologists.
- John_W._Semple subject Category:Canadian_medical_researchers.
- John_W._Semple subject Category:Canadian_scientists.
- John_W._Semple subject Category:Living_people.
- John_W._Semple subject Category:Medical_educators.
- John_W._Semple subject Category:University_of_Toronto_faculty.
- John_W._Semple hypernym Scientist.
- John_W._Semple type Agent.
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- John_W._Semple type Person.
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- John_W._Semple type Person.
- John_W._Semple type Biologist.
- John_W._Semple type Educator.
- John_W._Semple type Immunologist.
- John_W._Semple type List.
- John_W._Semple type Scientist.
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- John_W._Semple comment "John W. Semple is a Canadian Scientist at St. Michael's Hospital and a Professor of Pharmacology at the University of Toronto. He was born in Windsor, Ontario in 1959 and received his PhD in Immunology at Queen's University at Kingston, Ontario. In 1991, Semple, along with John Freedman, discovered a T helper cell defect in patients with the bleeding disorder called immune thrombocytopenic purpura (ITP).".
- John_W._Semple label "John W. Semple".
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- John_W._Semple givenName "John W.".
- John_W._Semple isPrimaryTopicOf John_W._Semple.
- John_W._Semple name "John W. Semple".
- John_W._Semple name "Semple, John W.".
- John_W._Semple surname "Semple".