Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Jens_Christian_Skou> ?p ?o }
- Jens_Christian_Skou abstract "Jens Christian Skou (Danish pronunciation: [ˈjɛns kʁæsdjæn ˈsɡʌʊ̯ˀ]; born October 8, 1918) is a Danish medical doctor and Nobel laureate.Skou was born in Lemvig, Denmark to a wealthy family. His father Magnus Martinus Skou was a timber and coal merchant. His mother Ane-Margrethe Skou took over the company after the death of his father. At the age of 15 Skou entered a boarding school in Haslev, Zealand. He graduated in medicine from the University of Copenhagen in 1944 and received his doctorate in 1954. He began working at the Aarhus University in 1947 and was appointed professor of biophysics in 1977. He retired from the Aarhus University in 1988, but he has kept his offices at the Department of Physiology (today part of Department of Biomedicine).In 1997 he received the Nobel Prize in Chemistry (together with Paul D. Boyer and John E. Walker) for his discovery of Na+,K+-ATPase [1].Skou had taken a few years away from his clinical training in the early 1950s to study the action of local anaesthetics. He had discovered that a substance’s anaesthetic action was related to its ability to dissolve in a layer of the lipid part of the plasma membrane, the anaesthetic molecules affected the opening of sodium channels which he assumed to be protein. This, he argued, would affect the movement of sodium ions and make nerve cells inexcitable, thus causing anaesthesia.Skou thought that other types of membrane protein might also be affected by local anaesthetics dissolving in the lipid part of the membrane. He therefore had the idea of looking at an enzyme which was embedded in the membrane and finding out if its properties were affected by local anaesthetics. He looked at ATPase in crab nerves.The enzyme was there, but unfortunately its activity was very variable and he needed a highly active enzyme for his studies. Eventually he managed to discover that ATPase was most active when exposed to the right combination of sodium, potassium and magnesium ions. Only then did he realise that this enzyme might have something to do with the active movement of sodium and potassium across the plasma membrane. This idea had been postulated many years before, however, the mechanism was quite unknown.Skou published his findings. However, in his paper he was wary of identifying the enzyme with the active ion movement, so he left out the term “sodium-potassium pump” from the title of his paper. Indeed, he seems only gradually to have realised the importance of his discovery, and he continued his studies on local anaesthetics.In 1958 Skou went to a conference in Vienna to describe his work on cholinesterase. There he met Robert Post (born 1920 [2]), who had been studying the pumping of sodium and potassium in red blood cells. Post had recently discovered that three sodium ions were pumped out of the cell for every two potassium ions pumped in, and in his research he had made use of a substance called ouabain which had recently been shown to inhibit the pump.Post had not read Skou’s paper, but he was excited when Skou told him about his work with ATPase. Post asked whether the enzyme was inhibited by ouabain. At this stage Skou was unaware that ouabain inhibited the pump, but he immediately telephoned to his lab and arranged for the experiment to be done. Ouabain did indeed inhibit the enzyme, thus establishing a link between the enzyme and the sodium-potassium pump.".
- Jens_Christian_Skou award Nobel_Prize_in_Chemistry.
- Jens_Christian_Skou birthDate "1918-10-08".
- Jens_Christian_Skou birthPlace Denmark.
- Jens_Christian_Skou birthPlace Lemvig.
- Jens_Christian_Skou field Biochemistry.
- Jens_Christian_Skou field Biophysics.
- Jens_Christian_Skou field Physiology.
- Jens_Christian_Skou knownFor K+-ATPase.
- Jens_Christian_Skou nationality Denmark.
- Jens_Christian_Skou thumbnail Skou2008.jpg?width=300.
- Jens_Christian_Skou wikiPageExternalLink index.html.
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- Jens_Christian_Skou wikiPageWikiLink Aarhus_University.
- Jens_Christian_Skou wikiPageWikiLink Acta_Physiol._Scand..
- Jens_Christian_Skou wikiPageWikiLink Biochemical_Society.
- Jens_Christian_Skou wikiPageWikiLink Biochemistry.
- Jens_Christian_Skou wikiPageWikiLink Biochimica_et_Biophysica_Acta.
- Jens_Christian_Skou wikiPageWikiLink Biophysics.
- Jens_Christian_Skou wikiPageWikiLink Category:1918_births.
- Jens_Christian_Skou wikiPageWikiLink Category:Aarhus_University_faculty.
- Jens_Christian_Skou wikiPageWikiLink Category:Danish_Nobel_laureates.
- Jens_Christian_Skou wikiPageWikiLink Category:Danish_chemists.
- Jens_Christian_Skou wikiPageWikiLink Category:Danish_physiologists.
- Jens_Christian_Skou wikiPageWikiLink Category:Living_people.
- Jens_Christian_Skou wikiPageWikiLink Category:Members_of_the_European_Molecular_Biology_Organization.
- Jens_Christian_Skou wikiPageWikiLink Category:Members_of_the_United_States_National_Academy_of_Sciences.
- Jens_Christian_Skou wikiPageWikiLink Category:Nobel_laureates_in_Chemistry.
- Jens_Christian_Skou wikiPageWikiLink Category:University_of_Copenhagen_alumni.
- Jens_Christian_Skou wikiPageWikiLink Denmark.
- Jens_Christian_Skou wikiPageWikiLink John_E._Walker.
- Jens_Christian_Skou wikiPageWikiLink Journal_of_the_Norwegian_Medical_Association.
- Jens_Christian_Skou wikiPageWikiLink Lemvig.
- Jens_Christian_Skou wikiPageWikiLink Medicine.
- Jens_Christian_Skou wikiPageWikiLink Membrane_&_cell_biology.
- Jens_Christian_Skou wikiPageWikiLink K+-ATPase.
- Jens_Christian_Skou wikiPageWikiLink Nobel_Prize.
- Jens_Christian_Skou wikiPageWikiLink Nobel_Prize_in_Chemistry.
- Jens_Christian_Skou wikiPageWikiLink Ouabain.
- Jens_Christian_Skou wikiPageWikiLink Paul_D._Boyer.
- Jens_Christian_Skou wikiPageWikiLink Physiology.
- Jens_Christian_Skou wikiPageWikiLink Postepy_Biochem..
- Jens_Christian_Skou wikiPageWikiLink Science_(journal).
- Jens_Christian_Skou wikiPageWikiLink Ugeskrift_for_Læger.
- Jens_Christian_Skou wikiPageWikiLink University_of_Copenhagen.
- Jens_Christian_Skou wikiPageWikiLink Zealand.
- Jens_Christian_Skou wikiPageWikiLinkText "Jens C. Skou".
- Jens_Christian_Skou wikiPageWikiLinkText "Jens Christian Skou".
- Jens_Christian_Skou wikiPageWikiLinkText "Jens_Christian_Skou".
- Jens_Christian_Skou birthDate "1918-10-08".
- Jens_Christian_Skou birthPlace Denmark.
- Jens_Christian_Skou birthPlace Lemvig.
- Jens_Christian_Skou field Biochemistry.
- Jens_Christian_Skou field Biophysics.
- Jens_Christian_Skou field Physiology.
- Jens_Christian_Skou knownFor K+-ATPase.
- Jens_Christian_Skou name "Jens Christian Skou".
- Jens_Christian_Skou nationality Denmark.
- Jens_Christian_Skou prizes "1997".
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- Jens_Christian_Skou wikiPageUsesTemplate Template:Nobel_Prize_in_Chemistry_Laureates_1976-2000.
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- Jens_Christian_Skou subject Category:1918_births.
- Jens_Christian_Skou subject Category:Aarhus_University_faculty.
- Jens_Christian_Skou subject Category:Danish_Nobel_laureates.
- Jens_Christian_Skou subject Category:Danish_chemists.
- Jens_Christian_Skou subject Category:Danish_physiologists.
- Jens_Christian_Skou subject Category:Living_people.
- Jens_Christian_Skou subject Category:Members_of_the_European_Molecular_Biology_Organization.
- Jens_Christian_Skou subject Category:Members_of_the_United_States_National_Academy_of_Sciences.
- Jens_Christian_Skou subject Category:Nobel_laureates_in_Chemistry.
- Jens_Christian_Skou subject Category:University_of_Copenhagen_alumni.
- Jens_Christian_Skou hypernym Doctor.
- Jens_Christian_Skou type Agent.
- Jens_Christian_Skou type Award.
- Jens_Christian_Skou type Biologist.
- Jens_Christian_Skou type List.
- Jens_Christian_Skou type Person.
- Jens_Christian_Skou type Scientist.
- Jens_Christian_Skou type Person.
- Jens_Christian_Skou type Award.
- Jens_Christian_Skou type Biologist.
- Jens_Christian_Skou type Laureate.
- Jens_Christian_Skou type List.
- Jens_Christian_Skou type Member.
- Jens_Christian_Skou type Scientist.
- Jens_Christian_Skou type Agent.