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- JX-594 abstract "JX-594 is an oncolytic virus (also known as Pexa-Vec) developed by Jennerex and partners: Transgene S.A.; Lee's Pharmaceutical Holdings Ltd.; and Green Cross Corp. Pexa-Vec is designed to target and destroy cancer cells.JX-594 is a vaccinia poxvirus engineered by addition of the GM-CSF gene and deletion of the thymidine kinase gene which limits viral replication to cells with high levels of thymidine kinase, typically seen in cancer cells with a mutated RAS or p53 gene. The virus kills them by lysis and also expresses GM-CSF which may help initiate an anti-tumour immune response.It has orphan drug designation from US FDA and EUMA for the treatment of hepatocellular carcinoma (HCC).".
- JX-594 wikiPageExternalLink bell.asp.
- JX-594 wikiPageExternalLink www.jennerex.com.
- JX-594 wikiPageExternalLink www.pexavectrials.com.
- JX-594 wikiPageID "32946838".
- JX-594 wikiPageLength "3537".
- JX-594 wikiPageOutDegree "21".
- JX-594 wikiPageRevisionID "699705386".
- JX-594 wikiPageWikiLink Cancer_cell.
- JX-594 wikiPageWikiLink Category:Experimental_cancer_treatments.
- JX-594 wikiPageWikiLink Category:Virotherapy.
- JX-594 wikiPageWikiLink Granulocyte_macrophage_colony-stimulating_factor.
- JX-594 wikiPageWikiLink Green_Cross_(Japan).
- JX-594 wikiPageWikiLink Hepatocellular_carcinoma.
- JX-594 wikiPageWikiLink JX-594.
- JX-594 wikiPageWikiLink Jennerex.
- JX-594 wikiPageWikiLink Lysis.
- JX-594 wikiPageWikiLink Oncolytic_virus.
- JX-594 wikiPageWikiLink Orphan_drug.
- JX-594 wikiPageWikiLink P53.
- JX-594 wikiPageWikiLink Poxviridae.
- JX-594 wikiPageWikiLink Ras_subfamily.
- JX-594 wikiPageWikiLink Sorafenib.
- JX-594 wikiPageWikiLink Survival_rate.
- JX-594 wikiPageWikiLink Thymidine_kinase.
- JX-594 wikiPageWikiLink Transgene_SA.
- JX-594 wikiPageWikiLink Vaccinia.
- JX-594 wikiPageWikiLinkText "JX-594".
- JX-594 wikiPageWikiLinkText "JX594/TG6006 (Pexa-Vec)".
- JX-594 wikiPageUsesTemplate Template:Reflist.
- JX-594 wikiPageUsesTemplate Template:Update.
- JX-594 subject Category:Experimental_cancer_treatments.
- JX-594 subject Category:Virotherapy.
- JX-594 hypernym Virus.
- JX-594 type Species.
- JX-594 comment "JX-594 is an oncolytic virus (also known as Pexa-Vec) developed by Jennerex and partners: Transgene S.A.; Lee's Pharmaceutical Holdings Ltd.; and Green Cross Corp. Pexa-Vec is designed to target and destroy cancer cells.JX-594 is a vaccinia poxvirus engineered by addition of the GM-CSF gene and deletion of the thymidine kinase gene which limits viral replication to cells with high levels of thymidine kinase, typically seen in cancer cells with a mutated RAS or p53 gene.".
- JX-594 label "JX-594".
- JX-594 sameAs Q3816624.
- JX-594 sameAs JX-594.
- JX-594 sameAs JX-594.
- JX-594 sameAs m.0h51t_2.
- JX-594 sameAs Q3816624.
- JX-594 wasDerivedFrom JX-594?oldid=699705386.
- JX-594 isPrimaryTopicOf JX-594.