Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/JUNQ_and_IPOD> ?p ?o }
- JUNQ_and_IPOD abstract "JUNQ and IPOD are types of cytosolic protein inclusion bodies in eukaryotes.Neurodegenerative diseases, such as Parkinson's, Alzheimer's, and Huntington's, are associated and correlated with protein aggregation and accumulation of misfolded proteins in inclusion bodies. For many years, protein aggregation was considered a random process by which misfolded proteins stick to each other to form inclusions (imagine a bundle of hairs haphazardly piling up in a corner of a room). Moreover, protein aggregates were thought to be toxic agents and the cause for neuronal dysfunction and death. However, recent studies, using advanced methods (i.e. Fluorescence microscopy), show that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process:The JUNQ (JUxta Nuclear Quality control compartment)The IPOD (Insoluble Protein Deposit)JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling and processing of different kinds of misfolded proteins (e.g. ubiquitinated vs. non-ubiquitinated proteins). Segregation of toxic protein aggregates into JUNQ and IPOD inclusion bodies is a means by which mammalian cells can be rejuvenated through asymmetric division.Thus, the discovery of JUNQ and IPOD provided a new striking perspective of how cells manage misfolded aggregated proteins and gave convincing proof that protein aggregation is a non-random, well regulated and controlled cellular process. Furthermore, the discovery of JUNQ and IPOD suggested that in addition to temporal quality control (i.e. time dependent administration of damaged proteins) cells exploit homeostasis spatially: If degradation isn't available, protection of the cellular environment from a misfolded protein is accomplished by its sequestration to an aggregate inclusion.".
- JUNQ_and_IPOD thumbnail A_scheme_of_a_yeast_cell_harboring_JUNQ_and_IPOD_inclusions.png?width=300.
- JUNQ_and_IPOD wikiPageExternalLink protein-folding.html.
- JUNQ_and_IPOD wikiPageExternalLink www.kaganovichlab.com.
- JUNQ_and_IPOD wikiPageExternalLink research.html.
- JUNQ_and_IPOD wikiPageExternalLink livecellimaging.
- JUNQ_and_IPOD wikiPageExternalLink watch?v=FPCqvdsnJwQ.
- JUNQ_and_IPOD wikiPageExternalLink watch?v=_Q0oOcZminY.
- JUNQ_and_IPOD wikiPageID "36066758".
- JUNQ_and_IPOD wikiPageLength "21606".
- JUNQ_and_IPOD wikiPageOutDegree "168".
- JUNQ_and_IPOD wikiPageRevisionID "662587121".
- JUNQ_and_IPOD wikiPageWikiLink AAA_proteins.
- JUNQ_and_IPOD wikiPageWikiLink Actin.
- JUNQ_and_IPOD wikiPageWikiLink Ageing.
- JUNQ_and_IPOD wikiPageWikiLink Aggresome.
- JUNQ_and_IPOD wikiPageWikiLink Alzheimers_disease.
- JUNQ_and_IPOD wikiPageWikiLink Amyloid.
- JUNQ_and_IPOD wikiPageWikiLink Autophagy.
- JUNQ_and_IPOD wikiPageWikiLink Biochemistry.
- JUNQ_and_IPOD wikiPageWikiLink Category:Alzheimers_disease.
- JUNQ_and_IPOD wikiPageWikiLink Category:Articles_created_via_the_Article_Wizard.
- JUNQ_and_IPOD wikiPageWikiLink Category:Cell_imaging.
- JUNQ_and_IPOD wikiPageWikiLink Category:Fluorescence.
- JUNQ_and_IPOD wikiPageWikiLink Category:Huntingtons_disease.
- JUNQ_and_IPOD wikiPageWikiLink Category:Microscopy.
- JUNQ_and_IPOD wikiPageWikiLink Category:Neurodegenerative_disorders.
- JUNQ_and_IPOD wikiPageWikiLink Category:Neurological_disorders.
- JUNQ_and_IPOD wikiPageWikiLink Category:Organelles.
- JUNQ_and_IPOD wikiPageWikiLink Category:Protein_complexes.
- JUNQ_and_IPOD wikiPageWikiLink Category:Protein_structure.
- JUNQ_and_IPOD wikiPageWikiLink Category:Proteins.
- JUNQ_and_IPOD wikiPageWikiLink Category:Structural_proteins.
- JUNQ_and_IPOD wikiPageWikiLink Category:Yeasts.
- JUNQ_and_IPOD wikiPageWikiLink Cell_fractionation.
- JUNQ_and_IPOD wikiPageWikiLink Cell_nucleus.
- JUNQ_and_IPOD wikiPageWikiLink Chaperone_(protein).
- JUNQ_and_IPOD wikiPageWikiLink Co-chaperone.
- JUNQ_and_IPOD wikiPageWikiLink Confocal_laser_scanning_microscopy.
- JUNQ_and_IPOD wikiPageWikiLink Conserved_sequence.
- JUNQ_and_IPOD wikiPageWikiLink Cytoskeleton.
- JUNQ_and_IPOD wikiPageWikiLink Cytosol.
- JUNQ_and_IPOD wikiPageWikiLink Endoplasmic-reticulum-associated_protein_degradation.
- JUNQ_and_IPOD wikiPageWikiLink Endoplasmic_reticulum.
- JUNQ_and_IPOD wikiPageWikiLink Eukaryote.
- JUNQ_and_IPOD wikiPageWikiLink Fluorescence_loss_in_photobleaching.
- JUNQ_and_IPOD wikiPageWikiLink Fluorescence_microscope.
- JUNQ_and_IPOD wikiPageWikiLink Fluorescence_recovery_after_photobleaching.
- JUNQ_and_IPOD wikiPageWikiLink Fungal_prion.
- JUNQ_and_IPOD wikiPageWikiLink Green_fluorescent_protein.
- JUNQ_and_IPOD wikiPageWikiLink Heat_shock.
- JUNQ_and_IPOD wikiPageWikiLink Heat_shock_protein.
- JUNQ_and_IPOD wikiPageWikiLink Homeostasis.
- JUNQ_and_IPOD wikiPageWikiLink Huntingtin.
- JUNQ_and_IPOD wikiPageWikiLink Huntingtons_disease.
- JUNQ_and_IPOD wikiPageWikiLink In_vivo.
- JUNQ_and_IPOD wikiPageWikiLink Inclusion_bodies.
- JUNQ_and_IPOD wikiPageWikiLink Membrane.
- JUNQ_and_IPOD wikiPageWikiLink Missense_mutation.
- JUNQ_and_IPOD wikiPageWikiLink Molecular_cloning.
- JUNQ_and_IPOD wikiPageWikiLink Mutant.
- JUNQ_and_IPOD wikiPageWikiLink Mutation.
- JUNQ_and_IPOD wikiPageWikiLink Native_state.
- JUNQ_and_IPOD wikiPageWikiLink Neurodegeneration.
- JUNQ_and_IPOD wikiPageWikiLink Parkinsons_disease.
- JUNQ_and_IPOD wikiPageWikiLink Physiology.
- JUNQ_and_IPOD wikiPageWikiLink Plasmid.
- JUNQ_and_IPOD wikiPageWikiLink Prion.
- JUNQ_and_IPOD wikiPageWikiLink Protease.
- JUNQ_and_IPOD wikiPageWikiLink Proteasome.
- JUNQ_and_IPOD wikiPageWikiLink Protein.
- JUNQ_and_IPOD wikiPageWikiLink Protein_aggregation.
- JUNQ_and_IPOD wikiPageWikiLink Protein_folding.
- JUNQ_and_IPOD wikiPageWikiLink Proteinogenic_amino_acid.
- JUNQ_and_IPOD wikiPageWikiLink Proteolysis.
- JUNQ_and_IPOD wikiPageWikiLink Proteome.
- JUNQ_and_IPOD wikiPageWikiLink Ribosome.
- JUNQ_and_IPOD wikiPageWikiLink SUMO_enzymes.
- JUNQ_and_IPOD wikiPageWikiLink Striatum.
- JUNQ_and_IPOD wikiPageWikiLink Substrate_(biology).
- JUNQ_and_IPOD wikiPageWikiLink Susan_Lindquist.
- JUNQ_and_IPOD wikiPageWikiLink Time-lapse_microscopy.
- JUNQ_and_IPOD wikiPageWikiLink Transformation_(genetics).
- JUNQ_and_IPOD wikiPageWikiLink Ubiquitin.
- JUNQ_and_IPOD wikiPageWikiLink Ubiquitin_ligase.
- JUNQ_and_IPOD wikiPageWikiLink Vacuole.
- JUNQ_and_IPOD wikiPageWikiLink Western_blot.
- JUNQ_and_IPOD wikiPageWikiLink Yeast.
- JUNQ_and_IPOD wikiPageWikiLink File:A_cell_harboring_JUNQ_and_IPOD_inclusions.png.
- JUNQ_and_IPOD wikiPageWikiLink File:A_scheme_of_a_yeast_cell_harboring_JUNQ_and_IPOD_inclusions.png.
- JUNQ_and_IPOD wikiPageWikiLink File:IPOD_(red)_tethered_to_the_vacuole_(green).tif.
- JUNQ_and_IPOD wikiPageWikiLink File:JUNQ_(green)_tethered_to_the_nucleus_(orange).tif.
- JUNQ_and_IPOD wikiPageWikiLinkText "IPOD".
- JUNQ_and_IPOD wikiPageWikiLinkText "JUNQ and IPOD".
- JUNQ_and_IPOD wikiPageWikiLinkText "JUNQ".
- JUNQ_and_IPOD wikiPageWikiLinkText "shown".
- JUNQ_and_IPOD wikiPageUsesTemplate Template:Reflist.
- JUNQ_and_IPOD subject Category:Alzheimers_disease.
- JUNQ_and_IPOD subject Category:Articles_created_via_the_Article_Wizard.
- JUNQ_and_IPOD subject Category:Cell_imaging.