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- JNJ-7925476 abstract "JNJ-7925476 is a TRI antidepressant currently under development by Johnson & Johnson.These molecules were first prepared by Bruce E. Maryanoff, et al. during the late 1970s – 1980's. and is known as a pyrroloisoquinoline, that is benzhydryl-containing. Incorporating the pyrrolidino ring onto the THIQ scaffolding markedly improves potency, although this only works for one of the available diastereo/enantiomers. JNJ-7925476 is a racemic preparation of the more potent diastereomer. The eutomer, JNJ-39836966 has (6R,10bS)-stereochemistry whereas the distomer JNJ-39836732 will have (6S,10bR)-stereochemistry. The compounds depicted appear to be cis but Maryanoff and coworkers are of the opinion that it is trans. (see abstract)The reason for this is not known because it was referred to as \"cis\" to begin with, only reassigning it later.Cyclohexane conformation".
- JNJ-7925476 iupacName "(±)-(6S,10bR)-6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline".
- JNJ-7925476 thumbnail Johnson123.png?width=300.
- JNJ-7925476 wikiPageID "23972572".
- JNJ-7925476 wikiPageLength "13392".
- JNJ-7925476 wikiPageOutDegree "37".
- JNJ-7925476 wikiPageRevisionID "706836332".
- JNJ-7925476 wikiPageWikiLink Altinicline.
- JNJ-7925476 wikiPageWikiLink Amfonelic_acid.
- JNJ-7925476 wikiPageWikiLink Amide.
- JNJ-7925476 wikiPageWikiLink Antidepressant.
- JNJ-7925476 wikiPageWikiLink Benzhydryl_compounds.
- JNJ-7925476 wikiPageWikiLink Bruce_E._Maryanoff.
- JNJ-7925476 wikiPageWikiLink Category:Alkynes.
- JNJ-7925476 wikiPageWikiLink Category:Johnson_&_Johnson.
- JNJ-7925476 wikiPageWikiLink Category:Pyrroloisoquinolines.
- JNJ-7925476 wikiPageWikiLink Category:Serotonin-norepinephrine-dopamine_reuptake_inhibitors.
- JNJ-7925476 wikiPageWikiLink Category:Stimulants.
- JNJ-7925476 wikiPageWikiLink Cyclohexane_conformation.
- JNJ-7925476 wikiPageWikiLink Diastereomer.
- JNJ-7925476 wikiPageWikiLink Erectile_dysfunction.
- JNJ-7925476 wikiPageWikiLink Erlotinib.
- JNJ-7925476 wikiPageWikiLink Ethynyl.
- JNJ-7925476 wikiPageWikiLink Eudysmic_ratio.
- JNJ-7925476 wikiPageWikiLink Ex_vivo.
- JNJ-7925476 wikiPageWikiLink Isoquinoline.
- JNJ-7925476 wikiPageWikiLink Johnson_&_Johnson.
- JNJ-7925476 wikiPageWikiLink Mandelic_acid.
- JNJ-7925476 wikiPageWikiLink Piperidine.
- JNJ-7925476 wikiPageWikiLink Pyrrolidine.
- JNJ-7925476 wikiPageWikiLink Pyrrolo.
- JNJ-7925476 wikiPageWikiLink Serotonin–norepinephrine–dopamine_reuptake_inhibitor.
- JNJ-7925476 wikiPageWikiLink Stereochemistry.
- JNJ-7925476 wikiPageWikiLink Styrene_oxide.
- JNJ-7925476 wikiPageWikiLink Tetrahydroisoquinoline.
- JNJ-7925476 wikiPageWikiLink File:2,2-Diphenylethylamine.svg.
- JNJ-7925476 wikiPageWikiLink File:2-Phenylpyrrolidine.svg.
- JNJ-7925476 wikiPageWikiLink File:Maryanoffs_antidepressant_number_12B_(1987)_with_tube_model.png.
- JNJ-7925476 wikiPageWikiLink File:Pyrroloisoquinoline.png.
- JNJ-7925476 wikiPageWikiLink File:Pyrroloisoquinoline_Synthesis.png.
- JNJ-7925476 wikiPageWikiLink File:Pyrroloisoquinoline_revised_synthesis.svg.
- JNJ-7925476 wikiPageWikiLinkText "JNJ-7925476".
- JNJ-7925476 c "20".
- JNJ-7925476 h "19".
- JNJ-7925476 iupacName "--6--1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline".
- JNJ-7925476 molecularWeight "273.371".
- JNJ-7925476 n "1".
- JNJ-7925476 smiles "C#CC1=CC=CC=C1".
- JNJ-7925476 verifiedrevid "444292126".
- JNJ-7925476 watchedfields "changed".
- JNJ-7925476 wikiPageUsesTemplate Template:Adrenergics.
- JNJ-7925476 wikiPageUsesTemplate Template:Antidepressants.
- JNJ-7925476 wikiPageUsesTemplate Template:Dopaminergics.
- JNJ-7925476 wikiPageUsesTemplate Template:Drugbox.
- JNJ-7925476 wikiPageUsesTemplate Template:Reflist.
- JNJ-7925476 wikiPageUsesTemplate Template:Serotonergics.
- JNJ-7925476 wikiPageUsesTemplate Template:Stimulants.
- JNJ-7925476 wikiPageUsesTemplate Template:US_Patent.
- JNJ-7925476 subject Category:Alkynes.
- JNJ-7925476 subject Category:Johnson_&_Johnson.
- JNJ-7925476 subject Category:Pyrroloisoquinolines.
- JNJ-7925476 subject Category:Serotonin-norepinephrine-dopamine_reuptake_inhibitors.
- JNJ-7925476 subject Category:Stimulants.
- JNJ-7925476 hypernym Antidepressant.
- JNJ-7925476 type ChemicalSubstance.
- JNJ-7925476 type Company.
- JNJ-7925476 type Drug.
- JNJ-7925476 type Alkyne.
- JNJ-7925476 type Chemical.
- JNJ-7925476 type Company.
- JNJ-7925476 type Heterocycle.
- JNJ-7925476 type Hydrocarbon.
- JNJ-7925476 type Inhibitor.
- JNJ-7925476 type Psychoanaleptic.
- JNJ-7925476 type Redirect.
- JNJ-7925476 type Stimulant.
- JNJ-7925476 type ChemicalObject.
- JNJ-7925476 type Thing.
- JNJ-7925476 type Q8386.
- JNJ-7925476 comment "JNJ-7925476 is a TRI antidepressant currently under development by Johnson & Johnson.These molecules were first prepared by Bruce E. Maryanoff, et al. during the late 1970s – 1980's. and is known as a pyrroloisoquinoline, that is benzhydryl-containing. Incorporating the pyrrolidino ring onto the THIQ scaffolding markedly improves potency, although this only works for one of the available diastereo/enantiomers. JNJ-7925476 is a racemic preparation of the more potent diastereomer.".
- JNJ-7925476 label "JNJ-7925476".
- JNJ-7925476 sameAs Q6108571.
- JNJ-7925476 sameAs m.076t26d.
- JNJ-7925476 sameAs JNJ-7925476.
- JNJ-7925476 sameAs JNJ-7925476.
- JNJ-7925476 sameAs Q6108571.
- JNJ-7925476 wasDerivedFrom JNJ-7925476?oldid=706836332.
- JNJ-7925476 depiction Johnson123.png.
- JNJ-7925476 isPrimaryTopicOf JNJ-7925476.