Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Ivacaftor> ?p ?o }
- Ivacaftor abstract "Ivacaftor (trade name Kalydeco, developed as VX-770) is a drug approved for patients with a certain mutation of cystic fibrosis, which accounts for 4–5% cases of cystic fibrosis. Ivacaftor was developed by Vertex Pharmaceuticals in conjunction with the Cystic Fibrosis Foundation and is the first drug that treats the underlying cause rather than the symptoms of the disease. Called \"the most important new drug of 2012\", and \"a wonder drug\" it is one of the most expensive drugs, costing over US$300,000 per year, which has led to criticism of Vertex for the high cost.Cystic fibrosis is caused by any one of several defects in a protein, cystic fibrosis transmembrane conductance regulator (CFTR), which regulates fluid flow within cells and affects the components of sweat, digestive fluids, and mucus. One such defect is the G551D mutation, in which the amino acid glycine (G) in position 551 is replaced with aspartic acid (D). G551D is characterized by a dysfunctional CFTR protein on the cell surface. In the case of G551D, the protein is trafficked to the correct area, the epithelial cell surface, but once there the protein cannot transport chloride through the channel. Ivacaftor, a CFTR potentiator, improves the transport of chloride through the ion channel by binding to the channels directly to induce a non-conventional mode of gating which in turn increases the probability that the channel is open.".
- Ivacaftor atcPrefix "R07".
- Ivacaftor atcSuffix "AX02".
- Ivacaftor casNumber "873054-44-5".
- Ivacaftor chEBI "66901".
- Ivacaftor fdaUniiCode "1Y740ILL1Z".
- Ivacaftor iupacName "N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide".
- Ivacaftor pubchem "16220172".
- Ivacaftor thumbnail Ivacaftor.svg?width=300.
- Ivacaftor wikiPageExternalLink VX-770.
- Ivacaftor wikiPageID "30995223".
- Ivacaftor wikiPageLength "20406".
- Ivacaftor wikiPageOutDegree "31".
- Ivacaftor wikiPageRevisionID "674130842".
- Ivacaftor wikiPageWikiLink Alberta.
- Ivacaftor wikiPageWikiLink Albumin.
- Ivacaftor wikiPageWikiLink Aspartic_acid.
- Ivacaftor wikiPageWikiLink Ataluren.
- Ivacaftor wikiPageWikiLink Category:Anilides.
- Ivacaftor wikiPageWikiLink Category:Breakthrough_therapy.
- Ivacaftor wikiPageWikiLink Category:Cystic_fibrosis.
- Ivacaftor wikiPageWikiLink Category:Phenols.
- Ivacaftor wikiPageWikiLink Category:Quinolones.
- Ivacaftor wikiPageWikiLink Cystic_Fibrosis_Foundation.
- Ivacaftor wikiPageWikiLink Cystic_fibrosis.
- Ivacaftor wikiPageWikiLink Cystic_fibrosis_transmembrane_conductance_regulator.
- Ivacaftor wikiPageWikiLink Deb_Matthews.
- Ivacaftor wikiPageWikiLink Food_and_Drug_Administration.
- Ivacaftor wikiPageWikiLink Glycine.
- Ivacaftor wikiPageWikiLink In_vitro.
- Ivacaftor wikiPageWikiLink In_vivo.
- Ivacaftor wikiPageWikiLink Lumacaftor.
- Ivacaftor wikiPageWikiLink ivacaftor.
- Ivacaftor wikiPageWikiLink National_Institute_for_Health_and_Care_Excellence.
- Ivacaftor wikiPageWikiLink National_Institutes_of_Health.
- Ivacaftor wikiPageWikiLink Ontario.
- Ivacaftor wikiPageWikiLink Ontario_Drug_Benefit.
- Ivacaftor wikiPageWikiLink Orosomucoid.
- Ivacaftor wikiPageWikiLink Pharmaceutical_drug.
- Ivacaftor wikiPageWikiLink Potentiator.
- Ivacaftor wikiPageWikiLink Quality-adjusted_life_year.
- Ivacaftor wikiPageWikiLink Saskatchewan.
- Ivacaftor wikiPageWikiLink United_States_dollar.
- Ivacaftor wikiPageWikiLink Vertex_Pharmaceuticals.
- Ivacaftor wikiPageWikiLinkText "Ivacaftor".
- Ivacaftor wikiPageWikiLinkText "Kalydeco".
- Ivacaftor wikiPageWikiLinkText "ivacaftor".
- Ivacaftor atcPrefix "R07".
- Ivacaftor atcSuffix "AX02".
- Ivacaftor c "24".
- Ivacaftor casNumber "873054".
- Ivacaftor chebi "66901".
- Ivacaftor chemspiderid "17347474".
- Ivacaftor eliminationHalfLife "43200.0".
- Ivacaftor excretion "88".
- Ivacaftor h "28".
- Ivacaftor inchi "InChI=1S/C24H28N2O3/c1-2316-11-172012-1926-2215-13-25-18-10-8-7-9-142128/h7-13,27H,1-6H3,".
- Ivacaftor iupacName "N--4-oxo-1,4-dihydroquinoline-3-carboxamide".
- Ivacaftor iupharLigand "4342".
- Ivacaftor legalUs "Rx-only".
- Ivacaftor licenceUs "Ivacaftor".
- Ivacaftor metabolism "CYP3A".
- Ivacaftor molecularWeight "392.49".
- Ivacaftor n "2".
- Ivacaftor o "3".
- Ivacaftor pregnancyUs "B".
- Ivacaftor proteinBound "99.0".
- Ivacaftor pubchem "16220172".
- Ivacaftor routesOfAdministration "Oral".
- Ivacaftor smiles "O=C\2c1cN/C=C/2CNc3cccCC".
- Ivacaftor stdinchi "1".
- Ivacaftor stdinchikey "PURKAOJPTOLRMP-UHFFFAOYSA-N".
- Ivacaftor synonyms "VX-770".
- Ivacaftor tradename "Kalydeco".
- Ivacaftor unii "1".
- Ivacaftor verifiedfields "changed".
- Ivacaftor verifiedrevid "477495886".
- Ivacaftor watchedfields "changed".
- Ivacaftor wikiPageUsesTemplate Template:Cascite.
- Ivacaftor wikiPageUsesTemplate Template:Chemspidercite.
- Ivacaftor wikiPageUsesTemplate Template:Drugbankcite.
- Ivacaftor wikiPageUsesTemplate Template:Drugbox.
- Ivacaftor wikiPageUsesTemplate Template:Ebicite.
- Ivacaftor wikiPageUsesTemplate Template:Fdacite.
- Ivacaftor wikiPageUsesTemplate Template:Other_respiratory_system_products.
- Ivacaftor wikiPageUsesTemplate Template:Reflist.
- Ivacaftor wikiPageUsesTemplate Template:Stdinchicite.
- Ivacaftor subject Category:Anilides.
- Ivacaftor subject Category:Breakthrough_therapy.
- Ivacaftor subject Category:Cystic_fibrosis.
- Ivacaftor subject Category:Phenols.
- Ivacaftor subject Category:Quinolones.
- Ivacaftor hypernym Drug.
- Ivacaftor type ChemicalSubstance.
- Ivacaftor type Drug.
- Ivacaftor type Alcohol.
- Ivacaftor type Chemical.
- Ivacaftor type Disorder.
- Ivacaftor type Pediatric.
- Ivacaftor type Redirect.