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- Integrase_inhibitor abstract "Integrase inhibitors, also known as integrase strand transfer inhibitors (INSTIs), are a class of antiretroviral drug designed to block the action of integrase, a viral enzyme that inserts the viral genome into the DNA of the host cell. Since integration is a vital step in retroviral replication, blocking it can halt further spread of the virus. Integrase inhibitors were initially developed for the treatment of HIV infection, but they could be applied to other retroviruses.The discovery and development of integrase inhibitors led to the first integrase inhibitor approval by the U.S. Food and Drug Administration (FDA) on October 12, 2007, for raltegravir (brand name Isentress). Research results published in the New England Journal of Medicine on July 24, 2008, concluded that \"raltegravir plus optimized background therapy provided better viral suppression than optimized background therapy alone for at least 48 weeks.\"Since integrase inhibitors target a distinct step in the retroviral life cycle, they may be taken in combination with other types of HIV drugs to minimize adaptation by the virus. They are also useful in salvage therapy for patients whose virus has mutated and acquired resistance to other drugs.".
- Integrase_inhibitor wikiPageExternalLink DrugDetailT.aspx?int_id=421.
- Integrase_inhibitor wikiPageExternalLink IntegraseBookFull.pdf.
- Integrase_inhibitor wikiPageExternalLink art00004?token=00461400d664264f65263a3d4f58762f467c405847447b23442f5f31256f5b20655d3b.
- Integrase_inhibitor wikiPageExternalLink eacs_3.htm.
- Integrase_inhibitor wikiPageExternalLink newdrugs.html.
- Integrase_inhibitor wikiPageID "7798584".
- Integrase_inhibitor wikiPageLength "4207".
- Integrase_inhibitor wikiPageOutDegree "27".
- Integrase_inhibitor wikiPageRevisionID "705055690".
- Integrase_inhibitor wikiPageWikiLink BI_224436.
- Integrase_inhibitor wikiPageWikiLink Bictegravir.
- Integrase_inhibitor wikiPageWikiLink Cabotegravir.
- Integrase_inhibitor wikiPageWikiLink Category:Integrase_inhibitors.
- Integrase_inhibitor wikiPageWikiLink DNA.
- Integrase_inhibitor wikiPageWikiLink Discovery_and_development_of_integrase_inhibitors.
- Integrase_inhibitor wikiPageWikiLink Dolutegravir.
- Integrase_inhibitor wikiPageWikiLink Elvitegravir.
- Integrase_inhibitor wikiPageWikiLink tenofovir.
- Integrase_inhibitor wikiPageWikiLink Food_and_Drug_Administration.
- Integrase_inhibitor wikiPageWikiLink Gilead_Sciences.
- Integrase_inhibitor wikiPageWikiLink HIV.
- Integrase_inhibitor wikiPageWikiLink Integrase.
- Integrase_inhibitor wikiPageWikiLink Japan_Tobacco.
- Integrase_inhibitor wikiPageWikiLink MK-2048.
- Integrase_inhibitor wikiPageWikiLink AIDS.
- Integrase_inhibitor wikiPageWikiLink Merck_&_Co..
- Integrase_inhibitor wikiPageWikiLink Quinolone.
- Integrase_inhibitor wikiPageWikiLink Raltegravir.
- Integrase_inhibitor wikiPageWikiLink Salvage_therapy.
- Integrase_inhibitor wikiPageWikiLink The_New_England_Journal_of_Medicine.
- Integrase_inhibitor wikiPageWikiLink ViiV_Healthcare.
- Integrase_inhibitor wikiPageWikiLinkText "INSTI".
- Integrase_inhibitor wikiPageWikiLinkText "Integrase inhibitor".
- Integrase_inhibitor wikiPageWikiLinkText "integrase inhibitor".
- Integrase_inhibitor wikiPageWikiLinkText "integrase nuclear strand inhibitors".
- Integrase_inhibitor wikiPageUsesTemplate Template:Antimicrobial-stub.
- Integrase_inhibitor wikiPageUsesTemplate Template:Cite_journal.
- Integrase_inhibitor wikiPageUsesTemplate Template:Enzyme_inhibition.
- Integrase_inhibitor wikiPageUsesTemplate Template:HIVpharm.
- Integrase_inhibitor wikiPageUsesTemplate Template:MeshName.
- Integrase_inhibitor wikiPageUsesTemplate Template:Reflist.
- Integrase_inhibitor wikiPageUsesTemplate Template:Update.
- Integrase_inhibitor subject Category:Integrase_inhibitors.
- Integrase_inhibitor hypernym Drug.
- Integrase_inhibitor type Drug.
- Integrase_inhibitor type Drug.
- Integrase_inhibitor type Inhibitor.
- Integrase_inhibitor comment "Integrase inhibitors, also known as integrase strand transfer inhibitors (INSTIs), are a class of antiretroviral drug designed to block the action of integrase, a viral enzyme that inserts the viral genome into the DNA of the host cell. Since integration is a vital step in retroviral replication, blocking it can halt further spread of the virus.".
- Integrase_inhibitor label "Integrase inhibitor".
- Integrase_inhibitor sameAs Q412251.
- Integrase_inhibitor sameAs Integrase-Inhibitor.
- Integrase_inhibitor sameAs Integraasinestäjät.
- Integrase_inhibitor sameAs Inhibiteur_de_lintxc3xa9grase.
- Integrase_inhibitor sameAs m.026dd4d.
- Integrase_inhibitor sameAs Zaviralci_integraze.
- Integrase_inhibitor sameAs Q412251.
- Integrase_inhibitor sameAs 整合酶抑制剂.
- Integrase_inhibitor wasDerivedFrom Integrase_inhibitor?oldid=705055690.
- Integrase_inhibitor isPrimaryTopicOf Integrase_inhibitor.