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Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Inhibitor_cystine_knot> ?p ?o }

• Inhibitor_cystine_knot abstract "An inhibitor cystine knot (ICK) is a protein structural motif containing three disulfide bridges. Along with the sections of polypeptide between them, two disulfides form a loop through which the third disulfide bond (linking the 3rd and 6th cysteine in the sequence) passes, forming a knot (thus the alternate name knottin). The motif is common in invertebrate toxins such as those from arachnids and molluscs. The motif is also found in some inhibitor proteins found in plants, but the plant and animal motifs are thought to be a product of convergent evolution. The ICK motif is a very stable protein structure which is resistant to heat denaturation and proteolysis.ICK peptide components of venoms target voltage-gated ion channels but members of the family also act as antibacterial and haemolytic agents. Plant ICK proteins are often protease inhibitors. Because of their stability, ICK motifs are being developed as possible therapeutics. The mammalian proteins Agouti signalling peptide and Agouti related peptide are the only know mammalian examples of this motif. Both are neuropeptides involved in cell signalling. The former is responsible for hair (fur) colouration.The motif is similar to the cyclic cystine knot or cyclotide, but lacks the cyclisation of the polypeptide backbone which is present in the latter family. The growth factor cystine knot (GFCK) shares the motif but its topology is such that it is the bond between the first and fourth disulphide which threads through the loop.".
• Inhibitor_cystine_knot thumbnail ICK_topology1.svg?width=300.
• Inhibitor_cystine_knot wikiPageExternalLink knottin.cbs.cnrs.fr.
• Inhibitor_cystine_knot wikiPageExternalLink knots.html.
• Inhibitor_cystine_knot wikiPageID "41336858".
• Inhibitor_cystine_knot wikiPageLength "4787".
• Inhibitor_cystine_knot wikiPageOutDegree "37".
• Inhibitor_cystine_knot wikiPageRevisionID "678239794".
• Inhibitor_cystine_knot wikiPageWikiLink Agouti-related_peptide.
• Inhibitor_cystine_knot wikiPageWikiLink Agouti_signalling_peptide.
• Inhibitor_cystine_knot wikiPageWikiLink Albumin_I.
• Inhibitor_cystine_knot wikiPageWikiLink Arachnid.
• Inhibitor_cystine_knot wikiPageWikiLink Category:Ion_channel_toxins.
• Inhibitor_cystine_knot wikiPageWikiLink Category:Neurotoxins.
• Inhibitor_cystine_knot wikiPageWikiLink Category:Protein_folds.
• Inhibitor_cystine_knot wikiPageWikiLink Category:Protein_structure.
• Inhibitor_cystine_knot wikiPageWikiLink Convergent_evolution.
• Inhibitor_cystine_knot wikiPageWikiLink Covalitoxin-II.
• Inhibitor_cystine_knot wikiPageWikiLink Cyclotide.
• Inhibitor_cystine_knot wikiPageWikiLink Cystine_knot.
• Inhibitor_cystine_knot wikiPageWikiLink Delta-palutoxin.
• Inhibitor_cystine_knot wikiPageWikiLink Delta_atracotoxin.
• Inhibitor_cystine_knot wikiPageWikiLink Denaturation_(biochemistry).
• Inhibitor_cystine_knot wikiPageWikiLink Disulfide.
• Inhibitor_cystine_knot wikiPageWikiLink Grammotoxin.
• Inhibitor_cystine_knot wikiPageWikiLink Guangxitoxin.
• Inhibitor_cystine_knot wikiPageWikiLink Hainantoxin.
• Inhibitor_cystine_knot wikiPageWikiLink Hanatoxin.
• Inhibitor_cystine_knot wikiPageWikiLink Heteroscodratoxin-1.
• Inhibitor_cystine_knot wikiPageWikiLink Huwentoxin.
• Inhibitor_cystine_knot wikiPageWikiLink Knot_(mathematics).
• Inhibitor_cystine_knot wikiPageWikiLink Maurocalcine.
• Inhibitor_cystine_knot wikiPageWikiLink Mollusca.
• Inhibitor_cystine_knot wikiPageWikiLink Phrixotoxin.
• Inhibitor_cystine_knot wikiPageWikiLink Protein.
• Inhibitor_cystine_knot wikiPageWikiLink Proteolysis.
• Inhibitor_cystine_knot wikiPageWikiLink Psalmotoxin.
• Inhibitor_cystine_knot wikiPageWikiLink Stromatoxin.
• Inhibitor_cystine_knot wikiPageWikiLink TLTx.
• Inhibitor_cystine_knot wikiPageWikiLink Tachystatin.
• Inhibitor_cystine_knot wikiPageWikiLink Vanillotoxin.
• Inhibitor_cystine_knot wikiPageWikiLink File:2m2q.png.
• Inhibitor_cystine_knot wikiPageWikiLink File:ICK_topology1.svg.
• Inhibitor_cystine_knot wikiPageWikiLinkText "ICK".
• Inhibitor_cystine_knot wikiPageWikiLinkText "Inhibitor Cystine Knot".
• Inhibitor_cystine_knot wikiPageWikiLinkText "Inhibitor cystine knot".
• Inhibitor_cystine_knot wikiPageWikiLinkText "cystine knot motif".
• Inhibitor_cystine_knot wikiPageWikiLinkText "cystine knot".
• Inhibitor_cystine_knot wikiPageWikiLinkText "inhibitor cysteine knot".
• Inhibitor_cystine_knot wikiPageWikiLinkText "inhibitor cystine knot motif".
• Inhibitor_cystine_knot wikiPageWikiLinkText "inhibitor cystine knot".
• Inhibitor_cystine_knot wikiPageWikiLinkText "knottin".
• Inhibitor_cystine_knot wikiPageWikiLinkText "knottins".
• Inhibitor_cystine_knot wikiPageUsesTemplate Template:Biochem-stub.
• Inhibitor_cystine_knot wikiPageUsesTemplate Template:PDBe.
• Inhibitor_cystine_knot wikiPageUsesTemplate Template:Reflist.
• Inhibitor_cystine_knot subject Category:Ion_channel_toxins.
• Inhibitor_cystine_knot subject Category:Neurotoxins.
• Inhibitor_cystine_knot subject Category:Protein_folds.
• Inhibitor_cystine_knot subject Category:Protein_structure.
• Inhibitor_cystine_knot hypernym Motif.
• Inhibitor_cystine_knot type Protein.
• Inhibitor_cystine_knot comment "An inhibitor cystine knot (ICK) is a protein structural motif containing three disulfide bridges. Along with the sections of polypeptide between them, two disulfides form a loop through which the third disulfide bond (linking the 3rd and 6th cysteine in the sequence) passes, forming a knot (thus the alternate name knottin). The motif is common in invertebrate toxins such as those from arachnids and molluscs.".
• Inhibitor_cystine_knot label "Inhibitor cystine knot".
• Inhibitor_cystine_knot sameAs Q17138737.
• Inhibitor_cystine_knot sameAs m.0zmynws.
• Inhibitor_cystine_knot sameAs Q17138737.
• Inhibitor_cystine_knot wasDerivedFrom Inhibitor_cystine_knot?oldid=678239794.
• Inhibitor_cystine_knot depiction ICK_topology1.svg.
• Inhibitor_cystine_knot isPrimaryTopicOf Inhibitor_cystine_knot.