Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Infliximab> ?p ?o }
- Infliximab abstract "Infliximab (INN; trade names Remicade, Remsima, Inflectra) is a chimeric monoclonal antibody biologic drug that works against tumour necrosis factor alpha (TNF-α) and is used to treat autoimmune diseases.Infliximab was approved by the U.S. Food and Drug Administration (FDA) for the treatment of Crohn's disease, ulcerative colitis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and rheumatoid arthritis. It is used off-label outside its FDA approval for Behçet's disease and other conditions.Infliximab works by binding to TNF-α. TNF-α is a chemical messenger (cytokine) and a key part of the autoimmune reaction.In rheumatoid arthritis, infliximab seems to work by preventing TNF-α from binding to its receptor in the cell.Infliximab is an artificial antibody. It was originally developed in mice as a mouse antibody. Because humans have immune reactions to mouse proteins, the mouse common domains were replaced with similar human antibody domains. They are monoclonal antibodies and have identical structures and affinities to the target. Because they are a combination of mouse and human antibody amino acid sequences, they are called a \"chimeric monoclonal antibody\".In the United States, Infliximab can cost $19,000 to $22,000 a year per patient wholesale, according to Centocor.Other monoclonal antibodies targeting TNF-α are golimumab (Simponi), adalimumab (Humira), and certolizumab pegol (Cimzia). Etanercept also binds and inhibits the action of TNF-α, but is not a monoclonal antibody (it is instead a fusion of TNF-receptor and an antibody constant region).Infliximab is administered by intravenous infusion, typically at six- to eight-week intervals, at a clinic or hospital. It cannot be administered orally because the digestive system would destroy the drug.".
- Infliximab atcPrefix "L04".
- Infliximab atcSuffix "AB02".
- Infliximab bioavailability "92.0".
- Infliximab casNumber "170277-31-3".
- Infliximab drugbank "DB00065".
- Infliximab fdaUniiCode "B72HH48FLU".
- Infliximab thumbnail Infliximab_structure2.jpg?width=300.
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- Infliximab wikiPageWikiLink George_Kollias_(biologist).
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- Infliximab wikiPageWikiLink Receptor_(biochemistry).
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- Infliximab wikiPageWikiLink Thrombocytopenia.
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- Infliximab wikiPageWikiLink Tuberculosis.