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- Immunologic_checkpoint abstract "An immune checkpoint regulator is a modulator of the immune system, that allow initiation of a productive immune response and prevent the onset of autoimmunity. Examples of such a molecule are cytotoxic T-lymphocyte antigen 4 (CTLA-4 or CD152), which is an inhibitory receptor found on immune cells and programmed cell death 1 (CD279), which has an important role in down-regulating the immune system by preventing the activation of T-cells.Tumours involve certain immune-checkpoint pathways as a major mechanism of immune resistance, particularly against T cells that are specific for tumor antigens. Therefore, the strategy in using immunological checkpoints in cancer therapy is to inhibit inhibitory molecules of the immune system, thus stimulating the immune system. The ability to interfere with the inhibitory function of checkpoint receptors CD152 and CD279 (programmed death-1) in oncology has proved successful. In metastatic melanoma FDA approved an αCD152 monoclonal antibody Ipilimumab, that was found to prolong survival. In melanoma, nonsmall cell lung cancer, and renal cell carcinoma there is hope with CD279 blocking Ab, that promotes antitumor responses. In hematologic malignancies a humanized αCD279 IgG1 needs further research. In solid tumors the use of CD279 IgG4 Ab is promising, and further CD273/PD-L2 in stage IV.In autoimmune rheumatic diseases, impaired tolerance leads to the development of diseases such as rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus, Sjogren’s syndrome, etc. Therefore, in autoimmune diseases the converse strategy of engaging immunological checkpoints may be beneficial: stimulate inhibitory molecules of the immune system, thus inhibiting the immune system (therefore, increase self-tolerance). What is known to work is Abatacept, an CD152-Ig used in treating rheumatoid arthritis and juvenile idiopathic arthritis.Not yet enough studied are the therapeutic opportunities using Programmed death-1 pathway.".
- Immunologic_checkpoint wikiPageID "47371486".
- Immunologic_checkpoint wikiPageLength "2508".
- Immunologic_checkpoint wikiPageOutDegree "13".
- Immunologic_checkpoint wikiPageRevisionID "680133223".
- Immunologic_checkpoint wikiPageWikiLink Autoimmune_disease.
- Immunologic_checkpoint wikiPageWikiLink CTLA-4.
- Immunologic_checkpoint wikiPageWikiLink Category:Immunology.
- Immunologic_checkpoint wikiPageWikiLink Juvenile_idiopathic_arthritis.
- Immunologic_checkpoint wikiPageWikiLink Melanoma.
- Immunologic_checkpoint wikiPageWikiLink Neoplasm.
- Immunologic_checkpoint wikiPageWikiLink Programmed_cell_death_protein_1.
- Immunologic_checkpoint wikiPageWikiLink Rheumatoid_arthritis.
- Immunologic_checkpoint wikiPageWikiLink Systemic_lupus_erythematosus.
- Immunologic_checkpoint wikiPageWikiLink Systemic_scleroderma.
- Immunologic_checkpoint wikiPageWikiLink T_cell.
- Immunologic_checkpoint wikiPageWikiLink Tumor_antigen.
- Immunologic_checkpoint wikiPageWikiLink Tumors_of_the_hematopoietic_and_lymphoid_tissues.
- Immunologic_checkpoint wikiPageWikiLinkText "Immunologic checkpoint".
- Immunologic_checkpoint wikiPageUsesTemplate Template:Reflist.
- Immunologic_checkpoint subject Category:Immunology.
- Immunologic_checkpoint hypernym Modulator.
- Immunologic_checkpoint type Drug.
- Immunologic_checkpoint comment "An immune checkpoint regulator is a modulator of the immune system, that allow initiation of a productive immune response and prevent the onset of autoimmunity.".
- Immunologic_checkpoint label "Immunologic checkpoint".
- Immunologic_checkpoint wasDerivedFrom Immunologic_checkpoint?oldid=680133223.
- Immunologic_checkpoint isPrimaryTopicOf Immunologic_checkpoint.