Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Idiotype> ?p ?o }
Showing triples 1 to 47 of
47
with 100 triples per page.
- Idiotype abstract "In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T cell receptor (TCR) molecules based upon the antigen binding specificity and therefore structure of their variable region. The word idiotype comes from two Greek roots, idio meaning 'private, distinctive, peculiar' and typos meaning 'mark.' Thus idiotype describes the distinctive sequence and region that makes any immunoglobing/TCR unique from others of the same type which is its variable region. The variable region of antigen receptors of T cells (TCRs) and B cells (immunoglobulins) contain complementarity determining regions (CDRs) with unique amino acid sequences. They define the surface and properties of the variable region, determining the antigen specificity and therefore the idiotope of the molecule. Immunoglobulins or TCRs with a shared idiotope are the same idiotype. Antibody idiotype is determined byGene rearrangementJunctional diversityP-nucleotides (palindromic nucleotides at sites of single-strand breaks)N-nucleotidesSomatic hypermutationsThe term idiotype is sometimes used to describe the collection of multiple idiotopes, and therefore overall antigen binding capacity, possessed by an antibody.The word idiotype became influential in immunology when Niels Jerne formulated his immune network theory. Jerne was awarded the Nobel Prize for Medicine or Physiology in 1984 largely for being the father of immune network theory. He defined idiotype as the set of epitopes on the V region of an antibody molecule, where epitope means an antigenic determinant. He also defined the \"paratope\" to be that part of an antibody variable region that binds to an antigen. The best developed version of immune network theory is called the symmetrical network theory, in which the distinction between idiotype and paratope plays no role.".
- Idiotype thumbnail AntibodyChains.svg?width=300.
- Idiotype wikiPageExternalLink IgTypes2000.htm.
- Idiotype wikiPageExternalLink igs.htm.
- Idiotype wikiPageID "10807821".
- Idiotype wikiPageLength "2504".
- Idiotype wikiPageOutDegree "19".
- Idiotype wikiPageRevisionID "666118700".
- Idiotype wikiPageWikiLink Allotype_(immunology).
- Idiotype wikiPageWikiLink Amino_acid.
- Idiotype wikiPageWikiLink Antibody.
- Idiotype wikiPageWikiLink Antigen.
- Idiotype wikiPageWikiLink B_cell.
- Idiotype wikiPageWikiLink Category:Immune_system.
- Idiotype wikiPageWikiLink Complementarity_determining_region.
- Idiotype wikiPageWikiLink Idiotopes.
- Idiotype wikiPageWikiLink Immune_network_theory.
- Idiotype wikiPageWikiLink Immunology.
- Idiotype wikiPageWikiLink Isotype_(immunology).
- Idiotype wikiPageWikiLink Medical_University_of_South_Carolina.
- Idiotype wikiPageWikiLink Niels_Kaj_Jerne.
- Idiotype wikiPageWikiLink Paratope.
- Idiotype wikiPageWikiLink Southern_Illinois_University_Carbondale.
- Idiotype wikiPageWikiLink T_cell.
- Idiotype wikiPageWikiLink T_cell_receptor.
- Idiotype wikiPageWikiLink File:AntibodyChains.svg.
- Idiotype wikiPageWikiLinkText "Idiotype".
- Idiotype wikiPageWikiLinkText "idiotype".
- Idiotype wikiPageWikiLinkText "idiotypic".
- Idiotype wikiPageUsesTemplate Template:Immune_system.
- Idiotype wikiPageUsesTemplate Template:MeshName.
- Idiotype wikiPageUsesTemplate Template:No_footnotes.
- Idiotype subject Category:Immune_system.
- Idiotype comment "In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T cell receptor (TCR) molecules based upon the antigen binding specificity and therefore structure of their variable region. The word idiotype comes from two Greek roots, idio meaning 'private, distinctive, peculiar' and typos meaning 'mark.' Thus idiotype describes the distinctive sequence and region that makes any immunoglobing/TCR unique from others of the same type which is its variable region.".
- Idiotype label "Idiotype".
- Idiotype sameAs Q1047644.
- Idiotype sameAs نمط_ذاتي_(مناعة).
- Idiotype sameAs Idiotyp_(Immunologie).
- Idiotype sameAs Idiotype.
- Idiotype sameAs Idiotipo.
- Idiotype sameAs Idiotipo.
- Idiotype sameAs Идиотиптер.
- Idiotype sameAs m.02qqmn8.
- Idiotype sameAs Q1047644.
- Idiotype wasDerivedFrom Idiotype?oldid=666118700.
- Idiotype depiction AntibodyChains.svg.
- Idiotype isPrimaryTopicOf Idiotype.