Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Iclaprim> ?p ?o }
- Iclaprim abstract "Iclaprim (INN), codenamed AR-100 and RO-48-2622, is a diaminopyrimidine dihydrofolate reductase (DHFR)-inhibiting extended-spectrum antibiotic active against gram positive organisms being developed for the treatment of complicated skin and soft tissue infections caused by antibiotic-resistant bacteria. It is structurally related to trimethoprim. In Phase III clinical trials, intravenously-administered iclaprim was found to be as effective as and better tolerated than linezolid in people with skin and soft tissue infections, many caused by methicillin-resistant Staphylococcus aureus (MRSA). In vitro, iclaprim is highly active against MRSA, vancomycin-resistant Staphylococcus aureus (VRSA), strains of Streptococcus pneumoniae resistant to several common antibiotics, and some Gram-negative bacteria.A new drug application for iclaprim was filed with the U.S. Food and Drug Administration in March 2008, and a marketing authorisation application (MAA) was accepted by the European Medicines Agency on August 21, 2008. Phase II clinical trials are being conducted to assess whether iclaprim can be taken by mouth as well as intravenously and whether it is effective for the treatment of hospital-acquired pneumonia.Iclaprim was granted fast track status by the FDA, but approval of the drug was eventually declined in 2009 and no further development has taken place since then.In Jan 2015, Motif BioSciences gained rights to iclaprim and planned to continue its development.".
- Iclaprim atcPrefix "J01".
- Iclaprim atcSuffix "EA03".
- Iclaprim casNumber "192314-93-5".
- Iclaprim fdaUniiCode "42445HUU0O".
- Iclaprim iupacName "(RS)-5-[(2- cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine".
- Iclaprim pubchem "213043".
- Iclaprim thumbnail Iclaprim2DACS.svg?width=300.
- Iclaprim wikiPageExternalLink sdarticle.pdf.
- Iclaprim wikiPageID "19014504".
- Iclaprim wikiPageLength "6848".
- Iclaprim wikiPageOutDegree "29".
- Iclaprim wikiPageRevisionID "707016679".
- Iclaprim wikiPageWikiLink Antimicrobial_resistance.
- Iclaprim wikiPageWikiLink Category:Aromatic_amines.
- Iclaprim wikiPageWikiLink Category:Bacterial_dihydrofolate_reductase_inhibitors.
- Iclaprim wikiPageWikiLink Category:Chromenes.
- Iclaprim wikiPageWikiLink Category:Cyclopropanes.
- Iclaprim wikiPageWikiLink Category:Phenol_ethers.
- Iclaprim wikiPageWikiLink Category:Pyrimidines.
- Iclaprim wikiPageWikiLink Clinical_trial.
- Iclaprim wikiPageWikiLink Diaminopyrimidine.
- Iclaprim wikiPageWikiLink Dihydrofolate_reductase.
- Iclaprim wikiPageWikiLink Enzyme_inhibitor.
- Iclaprim wikiPageWikiLink European_Medicines_Agency.
- Iclaprim wikiPageWikiLink FDA_Fast_Track_Development_Program.
- Iclaprim wikiPageWikiLink Food_and_Drug_Administration.
- Iclaprim wikiPageWikiLink Gram-negative_bacteria.
- Iclaprim wikiPageWikiLink Hospital-acquired_pneumonia.
- Iclaprim wikiPageWikiLink In_vitro.
- Iclaprim wikiPageWikiLink International_nonproprietary_name.
- Iclaprim wikiPageWikiLink Intravenous_therapy.
- Iclaprim wikiPageWikiLink Linezolid.
- Iclaprim wikiPageWikiLink Methicillin-resistant_Staphylococcus_aureus.
- Iclaprim wikiPageWikiLink New_drug_application.
- Iclaprim wikiPageWikiLink Racemic_mixture.
- Iclaprim wikiPageWikiLink Streptococcus_pneumoniae.
- Iclaprim wikiPageWikiLink Trimethoprim.
- Iclaprim wikiPageWikiLink Vancomycin-resistant_Staphylococcus_aureus.
- Iclaprim wikiPageWikiLink File:Staphylococcus_aureus_F98Y_DHFR_complexed_with_iclaprim_and_NADPH.gif.
- Iclaprim wikiPageWikiLinkText "Iclaprim".
- Iclaprim wikiPageWikiLinkText "iclaprim".
- Iclaprim atcPrefix "J01".
- Iclaprim atcSuffix "EA03".
- Iclaprim bioavailability "Good".
- Iclaprim c "19".
- Iclaprim casNumber "192314".
- Iclaprim chembl "134561".
- Iclaprim chemspiderid "184736".
- Iclaprim chirality Racemic_mixture.
- Iclaprim h "22".
- Iclaprim inchi "1".
- Iclaprim inchikey "HWJPWWYTGBZDEG-UHFFFAOYAK".
- Iclaprim iupacName "-5".
- Iclaprim kegg "D08337".
- Iclaprim legalStatus "Investigational".
- Iclaprim molecularWeight "354.403".
- Iclaprim n "4".
- Iclaprim o "3".
- Iclaprim pubchem "213043".
- Iclaprim routesOfAdministration "Oral, intravenous".
- Iclaprim smiles "COC1=COC".
- Iclaprim stdinchi "1".
- Iclaprim stdinchikey "HWJPWWYTGBZDEG-UHFFFAOYSA-N".
- Iclaprim unii "42445".
- Iclaprim verifiedfields "changed".
- Iclaprim verifiedrevid "416967709".
- Iclaprim watchedfields "changed".
- Iclaprim width "250".
- Iclaprim wikiPageUsesTemplate Template:Cascite.
- Iclaprim wikiPageUsesTemplate Template:Chemspidercite.
- Iclaprim wikiPageUsesTemplate Template:Cite_journal.
- Iclaprim wikiPageUsesTemplate Template:Clear-left.
- Iclaprim wikiPageUsesTemplate Template:Drugbankcite.
- Iclaprim wikiPageUsesTemplate Template:Drugbox.
- Iclaprim wikiPageUsesTemplate Template:Ebicite.
- Iclaprim wikiPageUsesTemplate Template:Fdacite.
- Iclaprim wikiPageUsesTemplate Template:Keggcite.
- Iclaprim wikiPageUsesTemplate Template:PDBe.
- Iclaprim wikiPageUsesTemplate Template:Reflist.
- Iclaprim wikiPageUsesTemplate Template:Stdinchicite.
- Iclaprim wikiPageUsesTemplate Template:Sulfonamides_and_trimethoprim.
- Iclaprim subject Category:Aromatic_amines.
- Iclaprim subject Category:Bacterial_dihydrofolate_reductase_inhibitors.
- Iclaprim subject Category:Chromenes.
- Iclaprim subject Category:Cyclopropanes.
- Iclaprim subject Category:Phenol_ethers.
- Iclaprim subject Category:Pyrimidines.
- Iclaprim hypernym Reductase.
- Iclaprim type ChemicalSubstance.
- Iclaprim type Drug.
- Iclaprim type Chemical.
- Iclaprim type Chromene.
- Iclaprim type Diazine.
- Iclaprim type Ether.
- Iclaprim type Inhibitor.
- Iclaprim type Redirect.
- Iclaprim type ChemicalObject.
- Iclaprim type Thing.
- Iclaprim type Q8386.