Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/IKZF1> ?p ?o }
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- IKZF1 abstract "DNA-binding protein Ikaros also known as Ikaros family zinc finger protein 1 is a protein that in humans is encoded by the IKZF1 gene. Ikaros displays crucial functions in the hematopoietic system and its loss of function has been linked to the development of lymphoid leukemia. In particular, Ikaros has been found in recent years to be a major tumor suppressor involved in human B-cell acute lymphoblastic leukemia. IKZF1 is upregulated in granulocytes, B cells, CD4 and CD8 T cells, and NK cells, and downregulated in erythroblasts, megakaryocytes and monocytes. In Ikaros knockout mice, T cells but not B cells are generated late in mouse development due to late compensatory expression of the related gene Aiolos (IKZF3). Ikaros point mutant mice are embryonic lethal due to anemia; they have severe defects in terminal erythrocyte and granulocyte differentiation, and excessive macrophage formation. SNPs located near the 3' region of IKZF1 in humans have been linked to susceptibility to childhood acute lymphoblastic leukemia (ALL) as well as type 1 diabetes. The two effects appear to be in opposite directions, with the allele marking susceptibility to ALL protecting from T1D and vice versa.".
- IKZF1 entrezgene "10320".
- IKZF1 wikiPageID "14754768".
- IKZF1 wikiPageLength "15539".
- IKZF1 wikiPageOutDegree "17".
- IKZF1 wikiPageRevisionID "701794591".
- IKZF1 wikiPageWikiLink Acute_lymphoblastic_leukemia.
- IKZF1 wikiPageWikiLink CTBP1.
- IKZF1 wikiPageWikiLink Category:Transcription_factors.
- IKZF1 wikiPageWikiLink Diabetes_mellitus_type_1.
- IKZF1 wikiPageWikiLink Gene.
- IKZF1 wikiPageWikiLink HDAC1.
- IKZF1 wikiPageWikiLink HDAC7.
- IKZF1 wikiPageWikiLink Histone_deacetylase_5.
- IKZF1 wikiPageWikiLink IKZF2.
- IKZF1 wikiPageWikiLink IKZF3.
- IKZF1 wikiPageWikiLink IKZF4.
- IKZF1 wikiPageWikiLink Protein.
- IKZF1 wikiPageWikiLink Protein–protein_interaction.
- IKZF1 wikiPageWikiLink SIN3A.
- IKZF1 wikiPageWikiLink SIN3B.
- IKZF1 wikiPageWikiLinkText "IKZF1".
- IKZF1 wikiPageUsesTemplate Template:Cite_journal.
- IKZF1 wikiPageUsesTemplate Template:Clear.
- IKZF1 wikiPageUsesTemplate Template:Div_col.
- IKZF1 wikiPageUsesTemplate Template:Div_col_end.
- IKZF1 wikiPageUsesTemplate Template:MeshName.
- IKZF1 wikiPageUsesTemplate Template:PBB.
- IKZF1 wikiPageUsesTemplate Template:Refbegin.
- IKZF1 wikiPageUsesTemplate Template:Refend.
- IKZF1 wikiPageUsesTemplate Template:Reflist.
- IKZF1 wikiPageUsesTemplate Template:Transcription_factors.
- IKZF1 wikiPageUsesTemplate Template:UCSC_gene_details.
- IKZF1 wikiPageUsesTemplate Template:UCSC_genome_browser.
- IKZF1 subject Category:Transcription_factors.
- IKZF1 hypernym Protein.
- IKZF1 type Biomolecule.
- IKZF1 type Protein.
- IKZF1 type Factor.
- IKZF1 type Thing.
- IKZF1 type Q206229.
- IKZF1 type Q8054.
- IKZF1 comment "DNA-binding protein Ikaros also known as Ikaros family zinc finger protein 1 is a protein that in humans is encoded by the IKZF1 gene. Ikaros displays crucial functions in the hematopoietic system and its loss of function has been linked to the development of lymphoid leukemia. In particular, Ikaros has been found in recent years to be a major tumor suppressor involved in human B-cell acute lymphoblastic leukemia.".
- IKZF1 label "IKZF1".
- IKZF1 sameAs Q18035293.
- IKZF1 sameAs IKZF1.
- IKZF1 sameAs m.03gwrq_.
- IKZF1 sameAs IKZF1.
- IKZF1 sameAs Q18035293.
- IKZF1 wasDerivedFrom IKZF1?oldid=701794591.
- IKZF1 isPrimaryTopicOf IKZF1.