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- IGF-1_LR3 abstract "Long arginine 3-IGF-1, abbreviated as IGF-1 LR3 or as LR3-IGF-1, is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1). It differs from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence (\"arginine 3\"), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) (\"long\"), for a total of 83 amino acids (relative to the 70 of IGF-1). The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability. As a result, it is approximately three times more potent than IGF-1, and possesses a significantly longer half-life of about 20–30 hours (relative to IGF-1's half-life of about 12–15 hours).The amino acid sequence of IGF-1 LR3 is MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA.".
- IGF-1_LR3 atcPrefix "None".
- IGF-1_LR3 casNumber "946870-92-4".
- IGF-1_LR3 wikiPageID "46964570".
- IGF-1_LR3 wikiPageLength "4873".
- IGF-1_LR3 wikiPageOutDegree "27".
- IGF-1_LR3 wikiPageRevisionID "695616826".
- IGF-1_LR3 wikiPageWikiLink Agonist.
- IGF-1_LR3 wikiPageWikiLink Amino_acid.
- IGF-1_LR3 wikiPageWikiLink Arginine.
- IGF-1_LR3 wikiPageWikiLink Biological_activity.
- IGF-1_LR3 wikiPageWikiLink Category:Growth_hormones.
- IGF-1_LR3 wikiPageWikiLink Category:Hormonal_agents.
- IGF-1_LR3 wikiPageWikiLink Category:Recombinant_proteins.
- IGF-1_LR3 wikiPageWikiLink Des(1-3)IGF-1.
- IGF-1_LR3 wikiPageWikiLink Drug_metabolism.
- IGF-1_LR3 wikiPageWikiLink Glutamic_acid.
- IGF-1_LR3 wikiPageWikiLink Half-life.
- IGF-1_LR3 wikiPageWikiLink Human.
- IGF-1_LR3 wikiPageWikiLink Injection_(medicine).
- IGF-1_LR3 wikiPageWikiLink Insulin-like_growth_factor-binding_protein.
- IGF-1_LR3 wikiPageWikiLink Insulin-like_growth_factor_1.
- IGF-1_LR3 wikiPageWikiLink Insulin-like_growth_factor_1_receptor.
- IGF-1_LR3 wikiPageWikiLink Insulin-like_growth_factor_2.
- IGF-1_LR3 wikiPageWikiLink Ligand_(biochemistry).
- IGF-1_LR3 wikiPageWikiLink Mecasermin.
- IGF-1_LR3 wikiPageWikiLink Mecasermin_rinfabate.
- IGF-1_LR3 wikiPageWikiLink N-terminus.
- IGF-1_LR3 wikiPageWikiLink Organic_compound.
- IGF-1_LR3 wikiPageWikiLink Peptide_sequence.
- IGF-1_LR3 wikiPageWikiLink Potency_(pharmacology).
- IGF-1_LR3 wikiPageWikiLink Protein.
- IGF-1_LR3 wikiPageWikiLink Structural_analog.
- IGF-1_LR3 wikiPageWikiLinkText "IGF-1 LR3".
- IGF-1_LR3 atcPrefix "None".
- IGF-1_LR3 c "400".
- IGF-1_LR3 casNumber "946870".
- IGF-1_LR3 eliminationHalfLife "-108000.0".
- IGF-1_LR3 h "625".
- IGF-1_LR3 molecularWeight "9117.5".
- IGF-1_LR3 n "111".
- IGF-1_LR3 o "115".
- IGF-1_LR3 routesOfAdministration Injection_(medicine).
- IGF-1_LR3 s "9".
- IGF-1_LR3 synonyms "IGF-1 Long R3".
- IGF-1_LR3 synonyms "Long R3-IGF-1;".
- IGF-1_LR3 wikiPageUsesTemplate Template:Drugbox.
- IGF-1_LR3 wikiPageUsesTemplate Template:Peptidergics.
- IGF-1_LR3 wikiPageUsesTemplate Template:Reflist.
- IGF-1_LR3 wikiPageUsesTemplate Template:Systemic-hormonal-drug-stub.
- IGF-1_LR3 subject Category:Growth_hormones.
- IGF-1_LR3 subject Category:Hormonal_agents.
- IGF-1_LR3 subject Category:Recombinant_proteins.
- IGF-1_LR3 hypernym Protein.
- IGF-1_LR3 type ChemicalSubstance.
- IGF-1_LR3 type Drug.
- IGF-1_LR3 type Protein.
- IGF-1_LR3 type ChemicalObject.
- IGF-1_LR3 type Thing.
- IGF-1_LR3 type Q8386.
- IGF-1_LR3 comment "Long arginine 3-IGF-1, abbreviated as IGF-1 LR3 or as LR3-IGF-1, is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1). It differs from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence (\"arginine 3\"), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) (\"long\"), for a total of 83 amino acids (relative to the 70 of IGF-1).".
- IGF-1_LR3 label "IGF-1 LR3".
- IGF-1_LR3 sameAs Q20707573.
- IGF-1_LR3 sameAs m.013dfy33.
- IGF-1_LR3 sameAs Q20707573.
- IGF-1_LR3 wasDerivedFrom IGF-1_LR3?oldid=695616826.
- IGF-1_LR3 isPrimaryTopicOf IGF-1_LR3.