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- IDRA-21 abstract "IDRA-21 is an ampakine drug and a benzothiadiazine derivative. IDRA-21 is a chiral molecule, with (+)-IDRA-21 being the active form.IDRA-21 shows nootropic effects in animal studies, significantly improving learning and memory. It is around 10–30 times more potent than aniracetam in reversing cognitive deficits induced by alprazolam or scopolamine, and produces sustained effects lasting for up to 48 hours after a single dose. The mechanism for this action is thought to be through promoting the induction of long-term potentiation between synapses in the brain.IDRA-21 does not produce neurotoxicity under normal conditions, although it may worsen neuronal damage following global ischemia after stroke or seizures.In comparison to the benzoylpiperidine derived ampakine drugs, IDRA-21 was more potent than CX-516, but less potent than CX-546. Newer benzothiadiazide derivatives with greatly increased potency compared to IDRA-21 have been developed, but these have not been researched to the same extent, with the benzoylpiperidine and benzoylpyrrolidine CX-series of drugs being favoured for clinical development, most likely due to more favourable toxicity profiles at high doses.".
- IDRA-21 casNumber "22503-72-6".
- IDRA-21 iupacName "7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide".
- IDRA-21 pubchem "3688".
- IDRA-21 thumbnail IDRA-21.svg?width=300.
- IDRA-21 wikiPageID "16185696".
- IDRA-21 wikiPageLength "7763".
- IDRA-21 wikiPageOutDegree "15".
- IDRA-21 wikiPageRevisionID "705243943".
- IDRA-21 wikiPageWikiLink Alprazolam.
- IDRA-21 wikiPageWikiLink Ampakine.
- IDRA-21 wikiPageWikiLink Aniracetam.
- IDRA-21 wikiPageWikiLink Benzothiadiazine.
- IDRA-21 wikiPageWikiLink CX-516.
- IDRA-21 wikiPageWikiLink CX-546.
- IDRA-21 wikiPageWikiLink Category:AMPA_receptor_agonists.
- IDRA-21 wikiPageWikiLink Category:Ampakines.
- IDRA-21 wikiPageWikiLink Category:Benzothiadiazines.
- IDRA-21 wikiPageWikiLink Category:Chloroarenes.
- IDRA-21 wikiPageWikiLink Diazoxide.
- IDRA-21 wikiPageWikiLink Hyoscine_hydrobromide.
- IDRA-21 wikiPageWikiLink Long-term_potentiation.
- IDRA-21 wikiPageWikiLink Nootropic.
- IDRA-21 wikiPageWikiLink S-18986.
- IDRA-21 wikiPageWikiLinkText "IDRA-21".
- IDRA-21 c "8".
- IDRA-21 casNumber "22503".
- IDRA-21 cl "1".
- IDRA-21 h "9".
- IDRA-21 iupacName "7".
- IDRA-21 iupharLigand "4219".
- IDRA-21 legalStatus "Investigational New Medicine".
- IDRA-21 molecularWeight "232.68726".
- IDRA-21 n "2".
- IDRA-21 o "2".
- IDRA-21 pubchem "3688".
- IDRA-21 s "1".
- IDRA-21 smiles "CC1NC2=CSN1".
- IDRA-21 verifiedrevid "424673085".
- IDRA-21 width "222".
- IDRA-21 wikiPageUsesTemplate Template:Cascite.
- IDRA-21 wikiPageUsesTemplate Template:Drugbankcite.
- IDRA-21 wikiPageUsesTemplate Template:Drugbox.
- IDRA-21 wikiPageUsesTemplate Template:Glutamatergics.
- IDRA-21 wikiPageUsesTemplate Template:Nootropics.
- IDRA-21 wikiPageUsesTemplate Template:Reflist.
- IDRA-21 subject Category:AMPA_receptor_agonists.
- IDRA-21 subject Category:Ampakines.
- IDRA-21 subject Category:Benzothiadiazines.
- IDRA-21 subject Category:Chloroarenes.
- IDRA-21 hypernym Drug.
- IDRA-21 type ChemicalSubstance.
- IDRA-21 type Drug.
- IDRA-21 type Chemical.
- IDRA-21 type Drug.
- IDRA-21 type Heterocycle.
- IDRA-21 type Modulator.
- IDRA-21 type Nootropic.
- IDRA-21 type Organohalide.
- IDRA-21 type Organohalide.
- IDRA-21 type ChemicalObject.
- IDRA-21 type Thing.
- IDRA-21 type Q8386.
- IDRA-21 comment "IDRA-21 is an ampakine drug and a benzothiadiazine derivative. IDRA-21 is a chiral molecule, with (+)-IDRA-21 being the active form.IDRA-21 shows nootropic effects in animal studies, significantly improving learning and memory. It is around 10–30 times more potent than aniracetam in reversing cognitive deficits induced by alprazolam or scopolamine, and produces sustained effects lasting for up to 48 hours after a single dose.".
- IDRA-21 label "IDRA-21".
- IDRA-21 sameAs Q5970086.
- IDRA-21 sameAs IDRA-21.
- IDRA-21 sameAs m.03wc836.
- IDRA-21 sameAs IDRA-21.
- IDRA-21 sameAs IDRA-21.
- IDRA-21 sameAs Q5970086.
- IDRA-21 wasDerivedFrom IDRA-21?oldid=705243943.
- IDRA-21 depiction IDRA-21.svg.
- IDRA-21 isPrimaryTopicOf IDRA-21.