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- Hypusine abstract "Hypusine is an unusual amino acid found in all eukaryotes and in some archaea, but not in bacteria. The only known protein containing hypusine is eukaryotic translation initiation factor 5A (eIF5A) and a similar protein found in archaebacteria. In humans, two isoforms of eIF-5A have been described: eIF5A-1 and eIF5A-2. They are encoded by two different genes EIF5A and EIF5A2. The protein is involved in protein biosynthesis and promotes the formation of the first peptide bond. The region surrounding the hypusine residue is highly conserved and is essential to the function of eIF5A. Thus, hypusine and eIF-5A appear to be vital for the viability and proliferation of eukaryotic cells.Hypusine is formed in eIF-5A by post-translational modification of one of the lysyl residues. There are two reactions and two enzymes involved:1. Deoxyhypusine synthase catalyzes the cleavage of the polyamine spermidine and transfer of its 4-aminobutyl moiety to the ε-amino group of one specific lysine residue of the eIF-5A precursor to form deoxyhypusine and 1,3-diaminopropane.2. Deoxyhypusine hydroxylase mediates the formation of hypusine by addition of a hydroxyl group to the deoxyhypusine residue.An excess of hypusine was found in the urine of children and patients with familial hyperlysinemia.Hypusine was first isolated from bovine brain by Japanese scientists Shiba et al. in 1971. The name hypusine indicates that the molecule comprises moieties of hydroxyputrescine and lysine.".
- Hypusine iupacName "2-Amino-6-[(4-amino-2-hydroxybutyl)amino]hexanoic acid".
- Hypusine thumbnail Hypusine_Coreys_font.gif?width=300.
- Hypusine wikiPageID "7146193".
- Hypusine wikiPageLength "5337".
- Hypusine wikiPageOutDegree "20".
- Hypusine wikiPageRevisionID "669722451".
- Hypusine wikiPageWikiLink 4-(γ-Glutamylamino)butanoic_acid.
- Hypusine wikiPageWikiLink Amino_acid.
- Hypusine wikiPageWikiLink Archaea.
- Hypusine wikiPageWikiLink Bacteria.
- Hypusine wikiPageWikiLink Category:Amino_acids.
- Hypusine wikiPageWikiLink DHPS.
- Hypusine wikiPageWikiLink Deoxyhypusine_monooxygenase.
- Hypusine wikiPageWikiLink EIF5A.
- Hypusine wikiPageWikiLink EIF5A2.
- Hypusine wikiPageWikiLink Eukaryote.
- Hypusine wikiPageWikiLink Eukaryotic_initiation_factor.
- Hypusine wikiPageWikiLink Hyperlysinemia.
- Hypusine wikiPageWikiLink Lysine.
- Hypusine wikiPageWikiLink Palmitoylethanolamide.
- Hypusine wikiPageWikiLink Peptide_bond.
- Hypusine wikiPageWikiLink Post-translational_modification.
- Hypusine wikiPageWikiLink Protein_biosynthesis.
- Hypusine wikiPageWikiLink Saccharopine.
- Hypusine wikiPageWikiLink Spermidine.
- Hypusine wikiPageWikiLinkText "Hypusine".
- Hypusine wikiPageWikiLinkText "hypusine".
- Hypusine imagefile "Hypusine_Coreys font.gif".
- Hypusine imagename "Stereo, partially condensed, skeletal formula of hypusine".
- Hypusine iupacname "2".
- Hypusine othernames "N6-lysine".
- Hypusine verifiedfields "changed".
- Hypusine verifiedrevid "428370486".
- Hypusine watchedfields "changed".
- Hypusine wikiPageUsesTemplate Template:Cascite.
- Hypusine wikiPageUsesTemplate Template:Chembox.
- Hypusine wikiPageUsesTemplate Template:Chembox_Identifiers.
- Hypusine wikiPageUsesTemplate Template:Chembox_Properties.
- Hypusine wikiPageUsesTemplate Template:Chembox_Related.
- Hypusine wikiPageUsesTemplate Template:Chemboximage.
- Hypusine wikiPageUsesTemplate Template:Chemspidercite.
- Hypusine wikiPageUsesTemplate Template:Citation_needed.
- Hypusine wikiPageUsesTemplate Template:Ebicite.
- Hypusine wikiPageUsesTemplate Template:Reflist.
- Hypusine wikiPageUsesTemplate Template:Stdinchicite.
- Hypusine subject Category:Amino_acids.
- Hypusine hypernym Acid.
- Hypusine type Biomolecule.
- Hypusine type ChemicalCompound.
- Hypusine type ChemicalSubstance.
- Hypusine type Biomolecule.
- Hypusine type Chemical.
- Hypusine type ChemicalObject.
- Hypusine type Thing.
- Hypusine type Q11173.
- Hypusine comment "Hypusine is an unusual amino acid found in all eukaryotes and in some archaea, but not in bacteria. The only known protein containing hypusine is eukaryotic translation initiation factor 5A (eIF5A) and a similar protein found in archaebacteria. In humans, two isoforms of eIF-5A have been described: eIF5A-1 and eIF5A-2. They are encoded by two different genes EIF5A and EIF5A2. The protein is involved in protein biosynthesis and promotes the formation of the first peptide bond.".
- Hypusine label "Hypusine".
- Hypusine sameAs Q2067805.
- Hypusine sameAs Hipusina.
- Hypusine sameAs هیپوسین.
- Hypusine sameAs Hypusine.
- Hypusine sameAs ヒプシン.
- Hypusine sameAs m.0h6nzw.
- Hypusine sameAs Гипузин.
- Hypusine sameAs Hipuzin.
- Hypusine sameAs Hipuzin.
- Hypusine sameAs Q2067805.
- Hypusine wasDerivedFrom Hypusine?oldid=669722451.
- Hypusine depiction Hypusine_Coreys_font.gif.
- Hypusine isPrimaryTopicOf Hypusine.