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- Hypericin abstract "Hypericin is a naphthodianthrone, a red-colored anthraquinone-derivative, which, together with hyperforin, is one of the principal active constituents of Hypericum (Saint John's wort). Hypericin is believed to act as an antibiotic, antiviral and non-specific kinase inhibitor. Hypericin may inhibit the action of the enzyme dopamine β-hydroxylase, leading to increased dopamine levels, although thus possibly decreasing norepinephrine and epinephrine.It was initially believed that the anti-depressant pharmacological activity of hypericin was due to inhibition of monoamine oxidase enzyme. The crude extract of Hypericum is a weak inhibitor of MAO-A and MAO-B. Isolated hypericin does not display this activity, but does have some affinity for NMDA receptors. This points in the direction that other constituents are responsible for the MAOI effect. The current belief is that the mechanism of antidepressant activity is due to the inhibition of reuptake of certain neurotransmitters.The large chromophore system in the molecule means that it can cause photosensitivity when ingested beyond threshold amounts. Photosensitivity is often seen in animals that have been allowed to graze on St. John's Wort. Because hypericin accumulates preferentially in cancerous tissues, it is also used as an indicator of cancerous cells. In addition, hypericin is under research as an agent in photodynamic therapy, whereby a biochemical is absorbed by an organism to be later activated with spectrum-specific light from specialized lamps or laser sources, for therapeutic purposes. The antibacterial and antiviral effects of hypericin are also believed to arise from its ability for photo-oxidation of cells and viral particles.Hypericin derives from polyketides cyclisation.The biosynthesis of hypericins is in the polyketide pathway where an octaketide chain goes through processes of cylizations and decarboxylations form emodin anthrone which are believed to be the precursors of hypericin. Oxidization reactions yield protoforms which then are converted into hypericin and pseudohypericin. Theses reactions are photosensitive and take place under exposure to light and using the enzyme Hyp-1.".
- Hypericin iupacName "1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione".
- Hypericin thumbnail Hypericin2DACS.svg?width=300.
- Hypericin wikiPageID "850783".
- Hypericin wikiPageLength "6530".
- Hypericin wikiPageOutDegree "25".
- Hypericin wikiPageRevisionID "692193259".
- Hypericin wikiPageWikiLink Anthraquinones.
- Hypericin wikiPageWikiLink Antibiotics.
- Hypericin wikiPageWikiLink Cancer.
- Hypericin wikiPageWikiLink Category:Natural_phenols.
- Hypericin wikiPageWikiLink Category:Virucides.
- Hypericin wikiPageWikiLink Chromophore.
- Hypericin wikiPageWikiLink Dopamine.
- Hypericin wikiPageWikiLink Dopamine_beta-hydroxylase.
- Hypericin wikiPageWikiLink Enzyme_inhibitor.
- Hypericin wikiPageWikiLink Epinephrine.
- Hypericin wikiPageWikiLink Hyperforin.
- Hypericin wikiPageWikiLink Hypericum.
- Hypericin wikiPageWikiLink Hypericum_perforatum.
- Hypericin wikiPageWikiLink Kinase.
- Hypericin wikiPageWikiLink Laser.
- Hypericin wikiPageWikiLink Monoamine_oxidase_A.
- Hypericin wikiPageWikiLink Monoamine_oxidase_B.
- Hypericin wikiPageWikiLink Monoamine_oxidase_inhibitor.
- Hypericin wikiPageWikiLink NMDA_receptor.
- Hypericin wikiPageWikiLink Norepinephrine.
- Hypericin wikiPageWikiLink Photodynamic_therapy.
- Hypericin wikiPageWikiLink Photosensitivity.
- Hypericin wikiPageWikiLink Photosensitivity_in_animals.
- Hypericin wikiPageWikiLink Polyketide.
- Hypericin wikiPageWikiLinkText "Hypericin".
- Hypericin wikiPageWikiLinkText "hypericin".
- Hypericin imagealt "Ball-and-stick model of the hypericin molecule".
- Hypericin imagealt "Structural formula of hypericin".
- Hypericin imagefile "Hypericin 3D ball.png".
- Hypericin imagefile "Hypericin2DACS.svg".
- Hypericin imagesize "200".
- Hypericin imagesize "220".
- Hypericin iupacname "1346813".
- Hypericin othernames "300.0".
- Hypericin verifiedrevid "443864519".
- Hypericin wikiPageUsesTemplate Template:Cascite.
- Hypericin wikiPageUsesTemplate Template:Chembox.
- Hypericin wikiPageUsesTemplate Template:Chembox_Hazards.
- Hypericin wikiPageUsesTemplate Template:Chembox_Identifiers.
- Hypericin wikiPageUsesTemplate Template:Chembox_Properties.
- Hypericin wikiPageUsesTemplate Template:Chemspidercite.
- Hypericin wikiPageUsesTemplate Template:Citation_needed.
- Hypericin wikiPageUsesTemplate Template:Ebicite.
- Hypericin wikiPageUsesTemplate Template:Fdacite.
- Hypericin wikiPageUsesTemplate Template:Glutamatergics.
- Hypericin wikiPageUsesTemplate Template:Neuropeptidergics.
- Hypericin wikiPageUsesTemplate Template:Reflist.
- Hypericin wikiPageUsesTemplate Template:Stdinchicite.
- Hypericin subject Category:Natural_phenols.
- Hypericin subject Category:Virucides.
- Hypericin hypernym Naphthodianthrone.
- Hypericin type Biomolecule.
- Hypericin type ChemicalCompound.
- Hypericin type ChemicalSubstance.
- Hypericin type Biomolecule.
- Hypericin type ChemicalObject.
- Hypericin type Thing.
- Hypericin type Q11173.
- Hypericin comment "Hypericin is a naphthodianthrone, a red-colored anthraquinone-derivative, which, together with hyperforin, is one of the principal active constituents of Hypericum (Saint John's wort). Hypericin is believed to act as an antibiotic, antiviral and non-specific kinase inhibitor.".
- Hypericin label "Hypericin".
- Hypericin sameAs Q425409.
- Hypericin sameAs Hypericin.
- Hypericin sameAs Hipericina.
- Hypericin sameAs Hüperitsiin.
- Hypericin sameAs هیپریسین.
- Hypericin sameAs Hipericin.
- Hypericin sameAs ヒペリシン.
- Hypericin sameAs m.03h24b.
- Hypericin sameAs Гиперицин.
- Hypericin sameAs Hipericin.
- Hypericin sameAs Hipericin.
- Hypericin sameAs Hypericin.
- Hypericin sameAs Q425409.
- Hypericin wasDerivedFrom Hypericin?oldid=692193259.
- Hypericin depiction Hypericin2DACS.svg.
- Hypericin isPrimaryTopicOf Hypericin.