Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Huntingtons_disease> ?p ?o }
- Huntingtons_disease abstract "Huntington's disease (HD) is a neurodegenerative genetic disorder that affects muscle coordination and leads to mental decline and behavioral symptoms. Symptoms of the disease can vary between individuals and affected members of the same family, but usually progress predictably. The earliest symptoms are often subtle problems with mood or cognition. A general lack of coordination and an unsteady gait often follow. As the disease advances, uncoordinated, jerky body movements become more apparent, along with a decline in mental abilities and behavioral symptoms. Physical abilities gradually worsen until coordinated movement becomes difficult. Mental abilities generally decline into dementia. Complications such as pneumonia, heart disease, and physical injury from falls reduce life expectancy to around twenty years from the point at which symptoms begin. Physical symptoms can begin at any age from infancy to old age, but usually begin between 35 and 44 years of age. The disease may develop earlier in life in each successive generation. About 6% of cases start before the age of 21 years with an akinetic-rigid syndrome; they progress faster and vary slightly. The variant is classified as juvenile, akinetic-rigid, or Westphal variant HD.HD is the most common genetic cause of abnormal involuntary writhing movements called chorea, which is why the disease used to be called Huntington's chorea. The disease is caused by an autosomal dominant mutation in either of an individual's two copies of a gene called Huntingtin. This means a child of an affected person typically has a 50% chance of inheriting the disease. The Huntingtin gene provides the genetic information for a protein that is also called \"huntingtin\". Expansion of a CAG (cytosine-adenine-guanine) triplet repeat stretch within the Huntingtin gene results in a different form of the protein, which gradually damages cells in the brain, through mechanisms that are not fully understood. Genetic testing can be performed at any stage of development, even before the onset of symptoms. This fact raises several ethical debates: the age at which an individual is considered mature enough to choose testing; whether parents have the right to have their children tested; and managing confidentiality and disclosure of test results. Genetic counseling has developed to inform and aid individuals considering genetic testing and has become a model for other genetically dominant diseases.There is no cure for HD. Full-time care is required in the later stages of the disease. Existing pharmaceutical and non-drug treatments can relieve some symptoms, but are still limited in improving quality of life. It is much more common in people of Western European descent than in those of Asian or African ancestry. The disease can affect both men and women.The genetic basis of HD was discovered in 1993 by an international collaborative effort spearheaded by the Hereditary Disease Foundation. Research and support organizations, first founded in the 1960s and increasing in number, work to increase public awareness, to provide support for individuals and their families, and to promote and facilitate research. Current research directions include determining the exact mechanism of the disease, improving animal models to expedite research, clinical trials of pharmaceuticals to treat symptoms or slow the progression of the disease, and studying procedures such as stem cell therapy with the goal of repairing damage caused by the disease.".
- Huntingtons_disease icd10 "G10,F02.2".
- Huntingtons_disease icd9 ",".
- Huntingtons_disease icd9 "294.1".
- Huntingtons_disease icd9 "333.4".
- Huntingtons_disease meshId "D006816".
- Huntingtons_disease omim "143100".
- Huntingtons_disease thumbnail Neuron_with_mHtt_inclusion.jpg?width=300.
- Huntingtons_disease wikiPageExternalLink hdbuzz.net.
- Huntingtons_disease wikiPageExternalLink hddrugworks.org.
- Huntingtons_disease wikiPageExternalLink hopes.stanford.edu.
- Huntingtons_disease wikiPageID "19449769".
- Huntingtons_disease wikiPageID "47878".
- Huntingtons_disease wikiPageLength "109261".
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- Huntingtons_disease wikiPageOutDegree "1".
- Huntingtons_disease wikiPageOutDegree "359".
- Huntingtons_disease wikiPageRedirects Huntingtons_disease.
- Huntingtons_disease wikiPageRevisionID "343612684".
- Huntingtons_disease wikiPageRevisionID "708285025".
- Huntingtons_disease wikiPageWikiLink Abdomen.
- Huntingtons_disease wikiPageWikiLink Abortion.
- Huntingtons_disease wikiPageWikiLink Abstraction.
- Huntingtons_disease wikiPageWikiLink Adenine.
- Huntingtons_disease wikiPageWikiLink Age_of_majority.
- Huntingtons_disease wikiPageWikiLink Age_of_onset.
- Huntingtons_disease wikiPageWikiLink Aggression.
- Huntingtons_disease wikiPageWikiLink Alcoholism.
- Huntingtons_disease wikiPageWikiLink Allele.
- Huntingtons_disease wikiPageWikiLink Allopatric_speciation.
- Huntingtons_disease wikiPageWikiLink Alzheimers_disease.
- Huntingtons_disease wikiPageWikiLink Amantadine.
- Huntingtons_disease wikiPageWikiLink Amino_acid.
- Huntingtons_disease wikiPageWikiLink Amniocentesis.
- Huntingtons_disease wikiPageWikiLink Animal_testing.
- Huntingtons_disease wikiPageWikiLink Anita_Harding.
- Huntingtons_disease wikiPageWikiLink Anticipation_(genetics).
- Huntingtons_disease wikiPageWikiLink Antiparkinson.
- Huntingtons_disease wikiPageWikiLink Antipsychotic.
- Huntingtons_disease wikiPageWikiLink Anxiety.
- Huntingtons_disease wikiPageWikiLink Apoptosis.
- Huntingtons_disease wikiPageWikiLink Astrocyte.
- Huntingtons_disease wikiPageWikiLink Astrogliosis.
- Huntingtons_disease wikiPageWikiLink Ataxia.
- Huntingtons_disease wikiPageWikiLink Atypical_antipsychotic.
- Huntingtons_disease wikiPageWikiLink Autosome.
- Huntingtons_disease wikiPageWikiLink Basal_ganglia.
- Huntingtons_disease wikiPageWikiLink Behavioral_addiction.
- Huntingtons_disease wikiPageWikiLink Benzodiazepine.
- Huntingtons_disease wikiPageWikiLink Boston.
- Huntingtons_disease wikiPageWikiLink Brain.
- Huntingtons_disease wikiPageWikiLink Brain-derived_neurotrophic_factor.
- Huntingtons_disease wikiPageWikiLink Breast_cancer.
- Huntingtons_disease wikiPageWikiLink CHDI_Foundation.
- Huntingtons_disease wikiPageWikiLink CREB-binding_protein.
- Huntingtons_disease wikiPageWikiLink CT_scan.
- Huntingtons_disease wikiPageWikiLink California.
- Huntingtons_disease wikiPageWikiLink Camillo_Golgi.
- Huntingtons_disease wikiPageWikiLink Cardiovascular_disease.
- Huntingtons_disease wikiPageWikiLink Caregiver.
- Huntingtons_disease wikiPageWikiLink Caspase.
- Huntingtons_disease wikiPageWikiLink Category:Autosomal_dominant_disorders.
- Huntingtons_disease wikiPageWikiLink Category:Disorders_causing_seizures.
- Huntingtons_disease wikiPageWikiLink Category:Extrapyramidal_and_movement_disorders.
- Huntingtons_disease wikiPageWikiLink Category:Genetic_disorders.
- Huntingtons_disease wikiPageWikiLink Category:Huntingtons_disease.
- Huntingtons_disease wikiPageWikiLink Category:Systemic_atrophies_primarily_affecting_the_central_nervous_system.
- Huntingtons_disease wikiPageWikiLink Category:Trinucleotide_repeat_disorders.
- Huntingtons_disease wikiPageWikiLink Caudate_nucleus.
- Huntingtons_disease wikiPageWikiLink Cell-free_fetal_DNA.
- Huntingtons_disease wikiPageWikiLink Cell_nucleus.
- Huntingtons_disease wikiPageWikiLink Cell_signaling.
- Huntingtons_disease wikiPageWikiLink Cerebellum.
- Huntingtons_disease wikiPageWikiLink Cerebral_atrophy.
- Huntingtons_disease wikiPageWikiLink Cerebral_cortex.
- Huntingtons_disease wikiPageWikiLink Chaperone_(protein).
- Huntingtons_disease wikiPageWikiLink Charles_Davenport.
- Huntingtons_disease wikiPageWikiLink Charles_Gorman_(physician).
- Huntingtons_disease wikiPageWikiLink Charles_Oscar_Waters.
- Huntingtons_disease wikiPageWikiLink Chorea.
- Huntingtons_disease wikiPageWikiLink Chorea_acanthocytosis.
- Huntingtons_disease wikiPageWikiLink Chorionic_villus_sampling.
- Huntingtons_disease wikiPageWikiLink Chromosome_4_(human).
- Huntingtons_disease wikiPageWikiLink Clinical_trial.
- Huntingtons_disease wikiPageWikiLink Coenzyme_Q10.
- Huntingtons_disease wikiPageWikiLink Cognition.
- Huntingtons_disease wikiPageWikiLink Compulsive_behavior.
- Huntingtons_disease wikiPageWikiLink Compulsory_sterilization.
- Huntingtons_disease wikiPageWikiLink Creatine.
- Huntingtons_disease wikiPageWikiLink Cytoplasm.
- Huntingtons_disease wikiPageWikiLink Cytosine.
- Huntingtons_disease wikiPageWikiLink DNA.
- Huntingtons_disease wikiPageWikiLink DNA_replication.
- Huntingtons_disease wikiPageWikiLink Dementia.
- Huntingtons_disease wikiPageWikiLink Dentatorubral-pallidoluysian_atrophy.
- Huntingtons_disease wikiPageWikiLink Dominance_(genetics).
- Huntingtons_disease wikiPageWikiLink Drosophila_melanogaster.
- Huntingtons_disease wikiPageWikiLink Drug_development.
- Huntingtons_disease wikiPageWikiLink Dynamic_mutation.
- Huntingtons_disease wikiPageWikiLink Dysarthria.