Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Human_leukocyte_antigen> ?p ?o }
- Human_leukocyte_antigen abstract "The human leukocyte antigen (HLA) system is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans. These cell-surface proteins are responsible for the regulation of the immune system in humans. The HLA gene complex resides on a 3 Mbp stretch within chromosome 6p21. HLA genes are highly polymorphic, which means that they have many different alleles, allowing them to fine-tune the adaptive immune system. The proteins encoded by certain genes are also known as antigens, as a result of their historic discovery as factors in organ transplants. Different classes have different functions:HLAs corresponding to MHC class I (A, B, and C) present peptides from inside the cell. For example, if the cell is infected by a virus, the HLA system brings fragments of the virus to the surface of the cell so that the cell can be destroyed by the immune system. These peptides are produced from digested proteins that are broken down in the proteasomes. In general, these particular peptides are small polymers, about 9 amino acids in length. Foreign antigens presented by MHC class I attract killer T-cells (also called CD8 positive- or cytotoxic T-cells) that destroy cells. MHC class I proteins associate with β2-microglobulin, which unlike the HLA proteins is encoded by a gene on chromosome 15.HLAs corresponding to MHC class II (DP, DM, DOA, DOB, DQ, and DR) present antigens from outside of the cell to T-lymphocytes. These particular antigens stimulate the multiplication of T-helper cells, which in turn stimulate antibody-producing B-cells to produce antibodies to that specific antigen. Self-antigens are suppressed by regulatory T cells.HLAs corresponding to MHC class III encode components of the complement system.HLAs have other roles. They are important in disease defense. They are the major cause of organ transplant rejections. They may protect against or fail to protect (if down-regulated by an infection) against cancers. Mutations in HLA may be linked to autoimmune disease (examples: type I diabetes, coeliac disease). HLA may also be related to people's perception of the odor of other people, and may be involved in mate selection, as at least one study found a lower-than-expected rate of HLA similarity between spouses in an isolated community.Aside from the genes encoding the 6 major antigen-presenting proteins, there are a large number of other genes, many involved in immune function, located on the HLA complex. Diversity of HLAs in the human population is one aspect of disease defense, and, as a result, the chance of two unrelated individuals with identical HLA molecules on all loci is very low. HLA genes have historically been identified as a result of the ability to successfully transplant organs between HLA-similar individuals.".
- Human_leukocyte_antigen thumbnail HLA.svg?width=300.
- Human_leukocyte_antigen wikiPageExternalLink hla.
- Human_leukocyte_antigen wikiPageExternalLink ashi-hla.org.
- Human_leukocyte_antigen wikiPageExternalLink cwd.immunogenomics.org.
- Human_leukocyte_antigen wikiPageExternalLink hla.alleles.org.
- Human_leukocyte_antigen wikiPageExternalLink www.allelefrequencies.net.
- Human_leukocyte_antigen wikiPageExternalLink hla6001a.asp.
- Human_leukocyte_antigen wikiPageExternalLink HIG.
- Human_leukocyte_antigen wikiPageExternalLink www.bshi.org.uk.
- Human_leukocyte_antigen wikiPageExternalLink www.efiweb.org.
- Human_leukocyte_antigen wikiPageExternalLink www.histocheck.org.
- Human_leukocyte_antigen wikiPageExternalLink mhc.
- Human_leukocyte_antigen wikiPageID "302013".
- Human_leukocyte_antigen wikiPageLength "42838".
- Human_leukocyte_antigen wikiPageOutDegree "133".
- Human_leukocyte_antigen wikiPageRevisionID "706131479".
- Human_leukocyte_antigen wikiPageWikiLink Adaptive_immune_system.
- Human_leukocyte_antigen wikiPageWikiLink Allele.
- Human_leukocyte_antigen wikiPageWikiLink Amino_acid.
- Human_leukocyte_antigen wikiPageWikiLink Ankylosing_spondylitis.
- Human_leukocyte_antigen wikiPageWikiLink Anthony_Nolan.
- Human_leukocyte_antigen wikiPageWikiLink Antibody.
- Human_leukocyte_antigen wikiPageWikiLink Antigen-presenting_cell.
- Human_leukocyte_antigen wikiPageWikiLink Autoimmune_disease.
- Human_leukocyte_antigen wikiPageWikiLink Autoimmune_hepatitis.
- Human_leukocyte_antigen wikiPageWikiLink B_cell.
- Human_leukocyte_antigen wikiPageWikiLink Balancing_selection.
- Human_leukocyte_antigen wikiPageWikiLink Beta-2_microglobulin.
- Human_leukocyte_antigen wikiPageWikiLink CD8.
- Human_leukocyte_antigen wikiPageWikiLink Category:Gene_complexes.
- Human_leukocyte_antigen wikiPageWikiLink Category:Genes_on_human_chromosome_6.
- Human_leukocyte_antigen wikiPageWikiLink Category:Human_MHC_haplogroups.
- Human_leukocyte_antigen wikiPageWikiLink Category:Immune_system.
- Human_leukocyte_antigen wikiPageWikiLink Cell_(biology).
- Human_leukocyte_antigen wikiPageWikiLink Chromosome_15_(human).
- Human_leukocyte_antigen wikiPageWikiLink Chromosome_6_(human).
- Human_leukocyte_antigen wikiPageWikiLink Coeliac_disease.
- Human_leukocyte_antigen wikiPageWikiLink Complement_system.
- Human_leukocyte_antigen wikiPageWikiLink Congenital_adrenal_hyperplasia_due_to_21-hydroxylase_deficiency.
- Human_leukocyte_antigen wikiPageWikiLink Cytotoxic_T_cell.
- Human_leukocyte_antigen wikiPageWikiLink Diabetes_mellitus_type_1.
- Human_leukocyte_antigen wikiPageWikiLink European_Bioinformatics_Institute.
- Human_leukocyte_antigen wikiPageWikiLink Gene_conversion.
- Human_leukocyte_antigen wikiPageWikiLink Genetic_matchmaking.
- Human_leukocyte_antigen wikiPageWikiLink HCP5.
- Human_leukocyte_antigen wikiPageWikiLink HLA-A.
- Human_leukocyte_antigen wikiPageWikiLink HLA-B.
- Human_leukocyte_antigen wikiPageWikiLink HLA-B27.
- Human_leukocyte_antigen wikiPageWikiLink HLA-B47.
- Human_leukocyte_antigen wikiPageWikiLink HLA-C.
- Human_leukocyte_antigen wikiPageWikiLink HLA-DM.
- Human_leukocyte_antigen wikiPageWikiLink HLA-DOA.
- Human_leukocyte_antigen wikiPageWikiLink HLA-DOB.
- Human_leukocyte_antigen wikiPageWikiLink HLA-DP.
- Human_leukocyte_antigen wikiPageWikiLink HLA-DPB1.
- Human_leukocyte_antigen wikiPageWikiLink HLA-DQ.
- Human_leukocyte_antigen wikiPageWikiLink HLA-DQ2.
- Human_leukocyte_antigen wikiPageWikiLink HLA-DQ8.
- Human_leukocyte_antigen wikiPageWikiLink HLA-DQB1.
- Human_leukocyte_antigen wikiPageWikiLink HLA-DR.
- Human_leukocyte_antigen wikiPageWikiLink HLA-DR2.
- Human_leukocyte_antigen wikiPageWikiLink HLA-DR3.
- Human_leukocyte_antigen wikiPageWikiLink HLA-DR4.
- Human_leukocyte_antigen wikiPageWikiLink HLA-DRB1.
- Human_leukocyte_antigen wikiPageWikiLink HLA-DRB3_(gene).
- Human_leukocyte_antigen wikiPageWikiLink HLA-DRB4.
- Human_leukocyte_antigen wikiPageWikiLink HLA-DRB5.
- Human_leukocyte_antigen wikiPageWikiLink HLA-E.
- Human_leukocyte_antigen wikiPageWikiLink HLA-F.
- Human_leukocyte_antigen wikiPageWikiLink HLA-G.
- Human_leukocyte_antigen wikiPageWikiLink HLA_A1-B8-DR3-DQ2.
- Human_leukocyte_antigen wikiPageWikiLink HLA_Informatics_Group.
- Human_leukocyte_antigen wikiPageWikiLink Hematopoietic_stem_cell_transplantation.
- Human_leukocyte_antigen wikiPageWikiLink History_and_naming_of_human_leukocyte_antigens.
- Human_leukocyte_antigen wikiPageWikiLink Immune_system.
- Human_leukocyte_antigen wikiPageWikiLink Inclusion_body_myositis.
- Human_leukocyte_antigen wikiPageWikiLink List_of_human_leukocyte_antigen_alleles_associated_with_cutaneous_conditions.
- Human_leukocyte_antigen wikiPageWikiLink Locus_(genetics).
- Human_leukocyte_antigen wikiPageWikiLink MHC_class_I.
- Human_leukocyte_antigen wikiPageWikiLink MHC_class_II.
- Human_leukocyte_antigen wikiPageWikiLink MHC_restriction.
- Human_leukocyte_antigen wikiPageWikiLink Major_histocompatibility_complex.
- Human_leukocyte_antigen wikiPageWikiLink Major_histocompatibility_complex,_class_II,_DP_alpha_1.
- Human_leukocyte_antigen wikiPageWikiLink Major_histocompatibility_complex,_class_II,_DQ_alpha_1.
- Human_leukocyte_antigen wikiPageWikiLink Membrane_protein.
- Human_leukocyte_antigen wikiPageWikiLink Myasthenia_gravis.
- Human_leukocyte_antigen wikiPageWikiLink Narcolepsy.
- Human_leukocyte_antigen wikiPageWikiLink Pathogen.
- Human_leukocyte_antigen wikiPageWikiLink Penguin_Books.
- Human_leukocyte_antigen wikiPageWikiLink Peptide.
- Human_leukocyte_antigen wikiPageWikiLink Phagocytosis.
- Human_leukocyte_antigen wikiPageWikiLink Polymer.
- Human_leukocyte_antigen wikiPageWikiLink Polymorphism_(biology).
- Human_leukocyte_antigen wikiPageWikiLink Preimplantation_genetic_diagnosis.
- Human_leukocyte_antigen wikiPageWikiLink Proteasome.
- Human_leukocyte_antigen wikiPageWikiLink Protein.
- Human_leukocyte_antigen wikiPageWikiLink Reactive_arthritis.
- Human_leukocyte_antigen wikiPageWikiLink Regulatory_T_cell.
- Human_leukocyte_antigen wikiPageWikiLink Relative_risk.