Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Human_accelerated_regions> ?p ?o }
Showing triples 1 to 75 of
75
with 100 triples per page.
- Human_accelerated_regions abstract "Human accelerated regions (HARs), first described in August 2006, are a set of 49 segments of the human genome that are conserved throughout vertebrate evolution but are strikingly different in humans. They are named according to their degree of difference between humans and chimpanzees (HAR1 showing the largest degree of human-chimpanzee differences). Found by scanning through genomic databases of multiple species, some of these highly mutated areas may contribute to human-specific traits. Others may represent loss of function mutations, possibly due to the action of biased gene conversion rather than adaptive evolution.Several of the HARs encompass genes known to produce proteins important in neurodevelopment. HAR1 is an 106-base pair stretch found on the long arm of chromosome 20 overlapping with part of the RNA genes HAR1F and HAR1R. HAR1F is active in the developing human brain. The HAR1 sequence is found (and conserved) in chickens and chimpanzees but is not present in fish or frogs that have been studied. There are 18 base pair mutations different between humans and chimpanzees, far more than expected by its history of conservation.HAR2 includes HACNS1 a gene enhancer \"that may have contributed to the evolution of the uniquely opposable human thumb, and possibly also modifications in the ankle or foot that allow humans to walk on two legs\". Evidence to date shows that of the 110,000 gene enhancer sequences identified in the human genome, HACNS1 has undergone the most change during the evolution of humans following the split with the ancestors of chimpanzees. The substitutions in HAR2 may have resulted in loss of binding sites for a repressor, possibly due to biased gene conversion.".
- Human_accelerated_regions thumbnail Details_of_HAR1–HAR5_journal.pgen.0020168.t001.png?width=300.
- Human_accelerated_regions wikiPageExternalLink index.html.
- Human_accelerated_regions wikiPageExternalLink haussler20060816.html.
- Human_accelerated_regions wikiPageExternalLink nature05113-s1.doc.
- Human_accelerated_regions wikiPageExternalLink article.cfm?chanID=sa003&articleID=00023D61-9116-14E3-911683414B7F0000.
- Human_accelerated_regions wikiPageExternalLink article.cfm?id=what-makes-us-human.
- Human_accelerated_regions wikiPageID "6513789".
- Human_accelerated_regions wikiPageLength "5693".
- Human_accelerated_regions wikiPageOutDegree "49".
- Human_accelerated_regions wikiPageRevisionID "594086377".
- Human_accelerated_regions wikiPageWikiLink AGBL4.
- Human_accelerated_regions wikiPageWikiLink AUTS2.
- Human_accelerated_regions wikiPageWikiLink Adaptive_evolution_in_the_human_genome.
- Human_accelerated_regions wikiPageWikiLink Ankle.
- Human_accelerated_regions wikiPageWikiLink CENTG2.
- Human_accelerated_regions wikiPageWikiLink Category:Molecular_genetics.
- Human_accelerated_regions wikiPageWikiLink Chimpanzee.
- Human_accelerated_regions wikiPageWikiLink Chromosome_20_(human).
- Human_accelerated_regions wikiPageWikiLink DNA_polymerase_I.
- Human_accelerated_regions wikiPageWikiLink Dystrophin.
- Human_accelerated_regions wikiPageWikiLink EBF_(gene).
- Human_accelerated_regions wikiPageWikiLink Enhancer_(genetics).
- Human_accelerated_regions wikiPageWikiLink Evolution.
- Human_accelerated_regions wikiPageWikiLink FHIT.
- Human_accelerated_regions wikiPageWikiLink Foot.
- Human_accelerated_regions wikiPageWikiLink Gene_conversion.
- Human_accelerated_regions wikiPageWikiLink Genome.
- Human_accelerated_regions wikiPageWikiLink Howard_Hughes_Medical_Institute.
- Human_accelerated_regions wikiPageWikiLink Human.
- Human_accelerated_regions wikiPageWikiLink Human_accelerated_region_1.
- Human_accelerated_regions wikiPageWikiLink Human_genome.
- Human_accelerated_regions wikiPageWikiLink ITPR1.
- Human_accelerated_regions wikiPageWikiLink KLHL14.
- Human_accelerated_regions wikiPageWikiLink LPHN4.
- Human_accelerated_regions wikiPageWikiLink MAD1L1.
- Human_accelerated_regions wikiPageWikiLink MGC27016.
- Human_accelerated_regions wikiPageWikiLink Mutation.
- Human_accelerated_regions wikiPageWikiLink NPAS3.
- Human_accelerated_regions wikiPageWikiLink Non-coding_RNA.
- Human_accelerated_regions wikiPageWikiLink POU_domain.
- Human_accelerated_regions wikiPageWikiLink PPARGC1A.
- Human_accelerated_regions wikiPageWikiLink PTPRT.
- Human_accelerated_regions wikiPageWikiLink SCAP2.
- Human_accelerated_regions wikiPageWikiLink Scientific_American.
- Human_accelerated_regions wikiPageWikiLink TBC1D22A.
- Human_accelerated_regions wikiPageWikiLink Thumb.
- Human_accelerated_regions wikiPageWikiLink Ultra-conserved_element.
- Human_accelerated_regions wikiPageWikiLink Vertebrate.
- Human_accelerated_regions wikiPageWikiLink WNK1.
- Human_accelerated_regions wikiPageWikiLink WWOX.
- Human_accelerated_regions wikiPageWikiLink Walking.
- Human_accelerated_regions wikiPageWikiLink Zinc_finger_and_BTB_domain-containing_protein_16.
- Human_accelerated_regions wikiPageWikiLink File:Details_of_HAR1–HAR5_journal.pgen.0020168.t001.png.
- Human_accelerated_regions wikiPageWikiLinkText "49 genomic region".
- Human_accelerated_regions wikiPageWikiLinkText "HAR20".
- Human_accelerated_regions wikiPageWikiLinkText "Human Accelerated Region".
- Human_accelerated_regions wikiPageWikiLinkText "Human accelerated regions".
- Human_accelerated_regions wikiPageWikiLinkText "human accelerated region".
- Human_accelerated_regions wikiPageWikiLinkText "human accelerated regions".
- Human_accelerated_regions wikiPageUsesTemplate Template:Reflist.
- Human_accelerated_regions subject Category:Molecular_genetics.
- Human_accelerated_regions hypernym Set.
- Human_accelerated_regions comment "Human accelerated regions (HARs), first described in August 2006, are a set of 49 segments of the human genome that are conserved throughout vertebrate evolution but are strikingly different in humans. They are named according to their degree of difference between humans and chimpanzees (HAR1 showing the largest degree of human-chimpanzee differences). Found by scanning through genomic databases of multiple species, some of these highly mutated areas may contribute to human-specific traits.".
- Human_accelerated_regions label "Human accelerated regions".
- Human_accelerated_regions sameAs Q1968369.
- Human_accelerated_regions sameAs مناطق_التعجيل_في_الإنسان.
- Human_accelerated_regions sameAs Human_accelerated_regions.
- Human_accelerated_regions sameAs m.0g87t4.
- Human_accelerated_regions sameAs Зоны_ускоренного_развития_у_человека.
- Human_accelerated_regions sameAs Людські_зони_акселерації.
- Human_accelerated_regions sameAs Q1968369.
- Human_accelerated_regions wasDerivedFrom Human_accelerated_regions?oldid=594086377.
- Human_accelerated_regions depiction Details_of_HAR1–HAR5_journal.pgen.0020168.t001.png.
- Human_accelerated_regions isPrimaryTopicOf Human_accelerated_regions.