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- Human_β-globin_locus abstract "The human β-globin locus is composed of five genes located on a short region of chromosome 11, responsible for the creation of the beta parts (roughly half) of the oxygen transport protein Hemoglobin. This locus contains not only the beta globin gene but also delta, gamma-A, gamma-G, and epsilon globin. Expression of all of these genes is controlled by single locus control region (LCR), and the genes are differentially expressed throughout development.The order of the genes in the beta-globin cluster is: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.The arrangement of the genes directly reflects the temporal differentiation of their expression during development, with the early-embryonic stage version of the gene located closest to the LCR. If the genes are rearranged, the gene products are expressed at improper stages of development.Expression of these genes is regulated in embryonic erythropoiesis by many transcription factors, including KLF1, which is associated with the upregulation of adult hemoglobin in adult definitive erythrocytes, and KLF2, which is vital to the expression of embryonic hemoglobin.".
- Human_β-globin_locus wikiPageExternalLink pmidlookup?view=long&pmid=2649166.
- Human_β-globin_locus wikiPageID "6179112".
- Human_β-globin_locus wikiPageLength "5408".
- Human_β-globin_locus wikiPageOutDegree "33".
- Human_β-globin_locus wikiPageRevisionID "707243183".
- Human_β-globin_locus wikiPageWikiLink BCL11A.
- Human_β-globin_locus wikiPageWikiLink Category:Chromosomes.
- Human_β-globin_locus wikiPageWikiLink Category:Hemoglobins.
- Human_β-globin_locus wikiPageWikiLink Chromosome_11_(human).
- Human_β-globin_locus wikiPageWikiLink Cis-regulatory_module.
- Human_β-globin_locus wikiPageWikiLink DNase_I_hypersensitive_site.
- Human_β-globin_locus wikiPageWikiLink DNase_footprinting_assay.
- Human_β-globin_locus wikiPageWikiLink Deoxyribonuclease_I.
- Human_β-globin_locus wikiPageWikiLink Embryonic_hemoglobin.
- Human_β-globin_locus wikiPageWikiLink Enhancer_(genetics).
- Human_β-globin_locus wikiPageWikiLink Erythropoiesis.
- Human_β-globin_locus wikiPageWikiLink GATA1.
- Human_β-globin_locus wikiPageWikiLink Gene.
- Human_β-globin_locus wikiPageWikiLink HBB.
- Human_β-globin_locus wikiPageWikiLink HBD.
- Human_β-globin_locus wikiPageWikiLink HBE1.
- Human_β-globin_locus wikiPageWikiLink HBG1.
- Human_β-globin_locus wikiPageWikiLink HBG2.
- Human_β-globin_locus wikiPageWikiLink Hemoglobin.
- Human_β-globin_locus wikiPageWikiLink Hemoglobin_A.
- Human_β-globin_locus wikiPageWikiLink K562_cells.
- Human_β-globin_locus wikiPageWikiLink KLF1.
- Human_β-globin_locus wikiPageWikiLink KLF2.
- Human_β-globin_locus wikiPageWikiLink Locus_control_region.
- Human_β-globin_locus wikiPageWikiLink Mammal.
- Human_β-globin_locus wikiPageWikiLink Peripheral_blood_derived_erythroblast.
- Human_β-globin_locus wikiPageWikiLink Red_blood_cell.
- Human_β-globin_locus wikiPageWikiLink Transcription_factor.
- Human_β-globin_locus wikiPageWikiLinkText "Human β-globin locus".
- Human_β-globin_locus wikiPageWikiLinkText "hemoglobin gene loci".
- Human_β-globin_locus wikiPageWikiLinkText "human β-globin locus".
- Human_β-globin_locus wikiPageWikiLinkText "human β-hemoglobin gene".
- Human_β-globin_locus wikiPageWikiLinkText "β-globin locus".
- Human_β-globin_locus wikiPageWikiLinkText "β-globin".
- Human_β-globin_locus wikiPageUsesTemplate Template:Chromosomes.
- Human_β-globin_locus wikiPageUsesTemplate Template:Cite_journal.
- Human_β-globin_locus wikiPageUsesTemplate Template:Hemeproteins.
- Human_β-globin_locus wikiPageUsesTemplate Template:Refbegin.
- Human_β-globin_locus wikiPageUsesTemplate Template:Refend.
- Human_β-globin_locus wikiPageUsesTemplate Template:Reflist.
- Human_β-globin_locus subject Category:Chromosomes.
- Human_β-globin_locus subject Category:Hemoglobins.
- Human_β-globin_locus type Diacritic.
- Human_β-globin_locus type Redirect.
- Human_β-globin_locus comment "The human β-globin locus is composed of five genes located on a short region of chromosome 11, responsible for the creation of the beta parts (roughly half) of the oxygen transport protein Hemoglobin. This locus contains not only the beta globin gene but also delta, gamma-A, gamma-G, and epsilon globin.".
- Human_β-globin_locus label "Human β-globin locus".
- Human_β-globin_locus sameAs Q423886.
- Human_β-globin_locus sameAs Β-Globin-Locus.
- Human_β-globin_locus sameAs m.0fvc_f.
- Human_β-globin_locus sameAs Q423886.
- Human_β-globin_locus wasDerivedFrom Human_β-globin_locus?oldid=707243183.
- Human_β-globin_locus isPrimaryTopicOf Human_β-globin_locus.