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- History_of_in_vitro_fertilisation abstract "The history of in vitro fertilisation goes back more than half a century.There was a transient biochemical pregnancy reported by Australian Foxton School researchers in 1953. John Rock was the first to extract an intact fertilised egg. In 1959, Min Chueh Chang at the Worcester Foundation, proved fertilisation in vitro was capable of proceeding to a birth of a live rabbit. Chang's discovery was seminal, as it clearly demonstrated that oocytes fertilised in vitro were capable of developing, if transferred into the uterus and thereby produce live young. The first pregnancy achieved through in vitro human fertilisation of a human oocyte was reported in The Lancet from the Monash University team of Carl Woods, John Leeton and Alan Trounson in 1973, although it lasted only a few days and would today be called a biochemical pregnancy. Landrum Shettles attempted to perform an IVF in 1973, but his departmental chairman interdicted the procedure at the last moment. There was also an ectopic pregnancy reported by Patrick Steptoe and Robert Edwards in 1976. In 1977, Steptoe and Edwards successfully carried out a pioneering conception which resulted in the birth of the world's first baby to be conceived by IVF, Louise Brown on 25 July 1978, in Oldham General Hospital, Greater Manchester, UK.In October 1978, it was reported that Subash Mukhopadyay, a relatively unknown physician from Kolkata, India was performing experiments on his own with primitive instruments and a household refrigerator and this resulted in a test tube baby, later named as \"Durga\" (alias Kanupriya Agarwal) who was born on 3 October 1978. However, state authorities prevented him from presenting his work at scientific conferences and, in the absence of scientific evidence, his work is not recognised by the international scientific community. These days, however, Mukhopadhyay's contribution is acknowledged in works dealing with the subject.Steptoe and Edwards were responsible for the world’s first confirmed boy conceived by IVF, Alastair MacDonald born on 14 January 1979 in Glasgow. A team led by Ian Johnston and Alex Lopata were responsible for Australia’s first baby conceived by IVF, Candice Reed born on 23 June 1980 in Melbourne. It was the subsequent use of stimulated cycles with clomiphene citrate and the use of human chorionic gonadotrophin (hCG) to control and time oocyte maturation, thus controlling the time of collection, that converted IVF from a research tool to a clinical treatment.This was followed by a total of 14 pregnancies resulting in nine births in 1981 with the Monash University team. Howard W. Jones and Georgeanna Seegar Jones at the Eastern Virginia Medical School in Norfolk, Virginia, further improved stimulated cycles by incorporating the use of a follicle-stimulating hormone (uHMG). This then became known as controlled ovarian hyperstimulation (COH). Another step forward was the use of gonadotrophin-releasing hormone agonists (GnRHA), thus decreasing the need for monitoring by preventing premature ovulation, and more recently gonadotrophin-releasing hormone antagonists (GnRH Ant), which have a similar function. The additional use of the oral contraceptive pill has allowed the scheduling of IVF cycles, which has made the treatment far more convenient for both staff and patients.The ability to freeze and subsequently thaw and transfer embryos has significantly improved the feasibility of IVF use. The other very significant milestone in IVF was the development of the intracytoplasmic sperm injection (ICSI) of single sperms by Gianpiero D. Palermo et al.in Brussels (UZ Brussel), 1992. This has enabled men with minimal sperm production to achieve pregnancies. ICSI is sometimes used in conjunction with sperm recovery, using a testicular fine needle or open testicular biopsy. Using this method, some men with Klinefelter's syndrome, and so would be otherwise infertile, have occasionally been able to achieve pregnancy. Thus, IVF has become the final solution for most fertility problems, moving from tubal disease to male factor, idiopathic subfertility, endometriosis, advanced maternal age, and anovulation not responding to ovulation induction.Robert Edwards was awarded the 2010 Nobel Prize in Physiology or Medicine \"for the development of in vitro fertilization\". Carl Wood was dubbed \"the father of IVF (in vitro fertilisation)\" for having pioneered the use of frozen embryos.In the US, ART cycles started in 2006 resulted in 41,343 births (54,656 infants), which is slightly more than 1% of total US births.".
- History_of_in_vitro_fertilisation wikiPageID "40963632".
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- History_of_in_vitro_fertilisation wikiPageOutDegree "24".
- History_of_in_vitro_fertilisation wikiPageRevisionID "704222408".
- History_of_in_vitro_fertilisation wikiPageWikiLink Advanced_maternal_age.
- History_of_in_vitro_fertilisation wikiPageWikiLink Carl_Wood.
- History_of_in_vitro_fertilisation wikiPageWikiLink Category:Reproduction.
- History_of_in_vitro_fertilisation wikiPageWikiLink Eastern_Virginia_Medical_School.
- History_of_in_vitro_fertilisation wikiPageWikiLink Georgeanna_Seegar_Jones.
- History_of_in_vitro_fertilisation wikiPageWikiLink Gianpiero_D._Palermo.
- History_of_in_vitro_fertilisation wikiPageWikiLink History.
- History_of_in_vitro_fertilisation wikiPageWikiLink Howard_W._Jones.
- History_of_in_vitro_fertilisation wikiPageWikiLink In_vitro_fertilisation.
- History_of_in_vitro_fertilisation wikiPageWikiLink John_Rock_(American_scientist).
- History_of_in_vitro_fertilisation wikiPageWikiLink Kolkata.
- History_of_in_vitro_fertilisation wikiPageWikiLink Landrum_Shettles.
- History_of_in_vitro_fertilisation wikiPageWikiLink Louise_Brown.
- History_of_in_vitro_fertilisation wikiPageWikiLink Min_Chueh_Chang.
- History_of_in_vitro_fertilisation wikiPageWikiLink Monash_University.
- History_of_in_vitro_fertilisation wikiPageWikiLink Nobel_Prize_in_Physiology_or_Medicine.
- History_of_in_vitro_fertilisation wikiPageWikiLink Norfolk,_Virginia.
- History_of_in_vitro_fertilisation wikiPageWikiLink Patrick_Steptoe.
- History_of_in_vitro_fertilisation wikiPageWikiLink Robert_Edwards_(physiologist).
- History_of_in_vitro_fertilisation wikiPageWikiLink Royal_Oldham_Hospital.
- History_of_in_vitro_fertilisation wikiPageWikiLink Subhash_Mukhopadhyay_(physician).
- History_of_in_vitro_fertilisation wikiPageWikiLink Vrije_Universiteit_Brussel.
- History_of_in_vitro_fertilisation wikiPageWikiLink Worcester_Foundation_for_Biomedical_Research.
- History_of_in_vitro_fertilisation wikiPageUsesTemplate Template:Reflist.
- History_of_in_vitro_fertilisation subject Category:Reproduction.
- History_of_in_vitro_fertilisation hypernym Pregnancy.
- History_of_in_vitro_fertilisation type Disease.
- History_of_in_vitro_fertilisation comment "The history of in vitro fertilisation goes back more than half a century.There was a transient biochemical pregnancy reported by Australian Foxton School researchers in 1953. John Rock was the first to extract an intact fertilised egg. In 1959, Min Chueh Chang at the Worcester Foundation, proved fertilisation in vitro was capable of proceeding to a birth of a live rabbit.".
- History_of_in_vitro_fertilisation label "History of in vitro fertilisation".
- History_of_in_vitro_fertilisation sameAs Q17030134.
- History_of_in_vitro_fertilisation sameAs m.0ywx4mk.
- History_of_in_vitro_fertilisation sameAs Q17030134.
- History_of_in_vitro_fertilisation wasDerivedFrom History_of_in_vitro_fertilisation?oldid=704222408.
- History_of_in_vitro_fertilisation isPrimaryTopicOf History_of_in_vitro_fertilisation.