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- High-content_screening abstract "High-content screening (HCS), also known as high-content analysis (HCA) or cellomics, is a method that is used in biological research and drug discovery to identify substances such as small molecules, peptides, or RNAi that alter the phenotype of a cell in a desired manner. Hence high content screening is a type of phenotypic screen conducted in cells. Phenotypic changes may include increases or decreases in the production of cellular products such as proteins and/or changes in the morphology (visual appearance) of the cell. High content screening includes any method used to analyze whole cells or components of cells with simultaneous readout of several parameters. Hence the name \"high content screening\". Unlike high-content analysis, high-content screening implies a level of throughput which is why the term \"screening\" differentiates HCS from HCA, which may be high in content but low in throughput.In high content screening, cells are first incubated with the substance and after a period of time, structures and molecular components of the cells are analyzed. The most common analysis involves labeling proteins with fluorescent tags, and finally changes in cell phenotype are measured using automated image analysis. Through the use of fluorescent tags with different absorption and emission maxima, it is possible to measure several different cell components in parallel. Furthermore, the imaging is able to detect changes at a subcellular level (e.g., cytoplasm vs. nucleus vs. other organelles). Therefore a large number of data points can be collected per cell. In addition to fluorescent labeling, various label free assays have been used in high content screening.".
- High-content_screening thumbnail Pills_on_uv_box.jpg?width=300.
- High-content_screening wikiPageExternalLink 33757.
- High-content_screening wikiPageExternalLink highcontent.2_Image_Technologies_and_Ins.
- High-content_screening wikiPageID "5824073".
- High-content_screening wikiPageLength "16339".
- High-content_screening wikiPageOutDegree "52".
- High-content_screening wikiPageRevisionID "696421963".
- High-content_screening wikiPageWikiLink Biological_target.
- High-content_screening wikiPageWikiLink Camera.
- High-content_screening wikiPageWikiLink Category:Drug_discovery.
- High-content_screening wikiPageWikiLink Category:Microscopy.
- High-content_screening wikiPageWikiLink Cell_(biology).
- High-content_screening wikiPageWikiLink Cell_biology.
- High-content_screening wikiPageWikiLink Cell_nucleus.
- High-content_screening wikiPageWikiLink Cellomics.
- High-content_screening wikiPageWikiLink Charge-coupled_device.
- High-content_screening wikiPageWikiLink Chemogenomics.
- High-content_screening wikiPageWikiLink Confocal.
- High-content_screening wikiPageWikiLink Confocal_microscopy.
- High-content_screening wikiPageWikiLink Cytoplasm.
- High-content_screening wikiPageWikiLink Cytoskeleton.
- High-content_screening wikiPageWikiLink Drug_discovery.
- High-content_screening wikiPageWikiLink File:Automated_confocal_image_reader.jpg.
- High-content_screening wikiPageWikiLink File:Pills_on_uv_box.jpg.
- High-content_screening wikiPageWikiLink Flow_cytometry.
- High-content_screening wikiPageWikiLink Fluorescence.
- High-content_screening wikiPageWikiLink Fluorescence_microscope.
- High-content_screening wikiPageWikiLink Fluorescent_tag.
- High-content_screening wikiPageWikiLink G_protein–coupled_receptor.
- High-content_screening wikiPageWikiLink Genome.
- High-content_screening wikiPageWikiLink Green_fluorescent_protein.
- High-content_screening wikiPageWikiLink High-throughput_screening.
- High-content_screening wikiPageWikiLink Hit_to_lead.
- High-content_screening wikiPageWikiLink Image_analysis.
- High-content_screening wikiPageWikiLink Immunofluorescence.
- High-content_screening wikiPageWikiLink Incubation_period.
- High-content_screening wikiPageWikiLink Microscope.
- High-content_screening wikiPageWikiLink Microscopy.
- High-content_screening wikiPageWikiLink Morphology_(biology).
- High-content_screening wikiPageWikiLink Organelle.
- High-content_screening wikiPageWikiLink Peptide.
- High-content_screening wikiPageWikiLink Pharmaceutical_drug.
- High-content_screening wikiPageWikiLink Phenotype.
- High-content_screening wikiPageWikiLink Phenotypic_screening.
- High-content_screening wikiPageWikiLink Protein.
- High-content_screening wikiPageWikiLink RNA_interference.
- High-content_screening wikiPageWikiLink Second_messenger_system.
- High-content_screening wikiPageWikiLink Signal_transduction.
- High-content_screening wikiPageWikiLink Small_molecule.
- High-content_screening wikiPageWikiLinkText "High content screening".
- High-content_screening wikiPageWikiLinkText "High-content Screening".
- High-content_screening wikiPageWikiLinkText "High-content screening".
- High-content_screening wikiPageWikiLinkText "High-content_screening".
- High-content_screening wikiPageWikiLinkText "high content analysis".
- High-content_screening wikiPageWikiLinkText "high-content screening (HCS)".
- High-content_screening wikiPageWikiLinkText "high-content screening".
- High-content_screening wikiPageUsesTemplate Template:Cite_journal.
- High-content_screening wikiPageUsesTemplate Template:Refbegin.
- High-content_screening wikiPageUsesTemplate Template:Refend.
- High-content_screening wikiPageUsesTemplate Template:Reflist.
- High-content_screening subject Category:Drug_discovery.
- High-content_screening subject Category:Microscopy.
- High-content_screening hypernym Method.
- High-content_screening type Software.
- High-content_screening type Technique.
- High-content_screening comment "High-content screening (HCS), also known as high-content analysis (HCA) or cellomics, is a method that is used in biological research and drug discovery to identify substances such as small molecules, peptides, or RNAi that alter the phenotype of a cell in a desired manner. Hence high content screening is a type of phenotypic screen conducted in cells.".
- High-content_screening label "High-content screening".
- High-content_screening sameAs Q5754482.
- High-content_screening sameAs m.0f7dml.
- High-content_screening sameAs Q5754482.
- High-content_screening wasDerivedFrom High-content_screening?oldid=696421963.
- High-content_screening depiction Pills_on_uv_box.jpg.
- High-content_screening isPrimaryTopicOf High-content_screening.