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- Herkinorin abstract "Herkinorin is an opioid analgesic that is an analogue of the natural product Salvinorin A. It was discovered in 2005 during structure-activity relationship studies into neoclerodane diterpenes, the family of chemical compounds of which Salvinorin A is a member.Unlike Salvinorin A which is a selective κ-opioid agonist with no significant μ-opioid receptor affinity, herkinorin is a μ-opioid agonist with more than 100x higher μ-opioid affinity and 50x lower κ-opioid affinity compared to Salvinorin A. Herkinorin is a semi-synthetic compound, made from Salvinorin B, which is most conveniently made from Salvinorin A by deacetylation, as while both Salvinorin A and Salvinorin B are found in the plant Salvia divinorum, Salvinorin A is present in larger quantities.A study in primates showed it to act as both a peripherally active μ and κ agonist with a fast onset of action. The study did not find any evidence of central activity in primates and questions whether herkinorin's effects are due entirely to peripheral binding. Unlike most μ-opioid agonists, herkinorin does not promote the recruitment of β-arrestin-2 to the intracellular domain of the μ-opioid receptor, or induce receptor internalization. This means that herkinorin may not produce tolerance and dependence in the same way as other opioids, although some development of tolerance through other mechanisms has been observed, and some other analogues related to herkinorin can recruit β-arrestins.".
- Herkinorin atcPrefix "none".
- Herkinorin iupacName "(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(benzoyloxy)-2-(3-furanyl)dodecahydro -6a,10b-dimethyl-4,10-dioxo-2H-naphtho-[2,1-c]pyran-7-carboxylic acid methyl ester".
- Herkinorin pubchem "11431898".
- Herkinorin thumbnail Herkinorin.svg?width=300.
- Herkinorin wikiPageID "13921871".
- Herkinorin wikiPageLength "6105".
- Herkinorin wikiPageOutDegree "22".
- Herkinorin wikiPageRevisionID "699637072".
- Herkinorin wikiPageWikiLink Agonist.
- Herkinorin wikiPageWikiLink Analgesic.
- Herkinorin wikiPageWikiLink Arrestin.
- Herkinorin wikiPageWikiLink Category:Benzoates.
- Herkinorin wikiPageWikiLink Category:Furans.
- Herkinorin wikiPageWikiLink Category:Kappa_agonists.
- Herkinorin wikiPageWikiLink Category:Methyl_esters.
- Herkinorin wikiPageWikiLink Category:Peripherally_selective_drugs.
- Herkinorin wikiPageWikiLink Category:Semisynthetic_opioids.
- Herkinorin wikiPageWikiLink Opioid.
- Herkinorin wikiPageWikiLink RB-64.
- Herkinorin wikiPageWikiLink Receptor-mediated_endocytosis.
- Herkinorin wikiPageWikiLink Receptor_(biochemistry).
- Herkinorin wikiPageWikiLink Salvia_divinorum.
- Herkinorin wikiPageWikiLink Salvinorin_A.
- Herkinorin wikiPageWikiLink Salvinorin_B_methoxymethyl_ether.
- Herkinorin wikiPageWikiLink Structural_analog.
- Herkinorin wikiPageWikiLink Κ-opioid_receptor.
- Herkinorin wikiPageWikiLink Μ-opioid_receptor.
- Herkinorin wikiPageWikiLinkText "Herkinorin".
- Herkinorin wikiPageWikiLinkText "herkinorin".
- Herkinorin atcPrefix "none".
- Herkinorin c "28".
- Herkinorin chembl "363324".
- Herkinorin chemspiderid "9606773".
- Herkinorin h "30".
- Herkinorin inchi "1".
- Herkinorin inchikey "PYDQMXRFUVDCHC-XAGHGKQIBW".
- Herkinorin iupacName "-9".
- Herkinorin legalStatus "Legal/Uncontrolled".
- Herkinorin molecularWeight "494.55".
- Herkinorin o "8".
- Herkinorin pubchem "11431898".
- Herkinorin smiles "O=C[C@H]3[C@@]4C".
- Herkinorin stdinchi "1".
- Herkinorin stdinchikey "PYDQMXRFUVDCHC-XAGHGKQISA-N".
- Herkinorin verifiedrevid "411131823".
- Herkinorin width "200".
- Herkinorin wikiPageUsesTemplate Template:Chemspidercite.
- Herkinorin wikiPageUsesTemplate Template:Drugbox.
- Herkinorin wikiPageUsesTemplate Template:Ebicite.
- Herkinorin wikiPageUsesTemplate Template:Opioidergics.
- Herkinorin wikiPageUsesTemplate Template:Reflist.
- Herkinorin wikiPageUsesTemplate Template:Stdinchicite.
- Herkinorin subject Category:Benzoates.
- Herkinorin subject Category:Furans.
- Herkinorin subject Category:Kappa_agonists.
- Herkinorin subject Category:Methyl_esters.
- Herkinorin subject Category:Peripherally_selective_drugs.
- Herkinorin subject Category:Semisynthetic_opioids.
- Herkinorin hypernym Analogue.
- Herkinorin type ChemicalSubstance.
- Herkinorin type Drug.
- Herkinorin type Agonist.
- Herkinorin type Chemical.
- Herkinorin type Drug.
- Herkinorin type Heterocycle.
- Herkinorin type Opioid.
- Herkinorin type ChemicalObject.
- Herkinorin type Thing.
- Herkinorin type Q8386.
- Herkinorin comment "Herkinorin is an opioid analgesic that is an analogue of the natural product Salvinorin A.".
- Herkinorin label "Herkinorin".
- Herkinorin sameAs Q4137203.
- Herkinorin sameAs ヘルキノリン.
- Herkinorin sameAs m.03cn8nv.
- Herkinorin sameAs Геркинорин.
- Herkinorin sameAs Herkinorin.
- Herkinorin sameAs Herkinorin.
- Herkinorin sameAs Q4137203.
- Herkinorin wasDerivedFrom Herkinorin?oldid=699637072.
- Herkinorin depiction Herkinorin.svg.
- Herkinorin isPrimaryTopicOf Herkinorin.