Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Hep_G2> ?p ?o }
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- Hep_G2 abstract "Hep G2 is a human liver cancer cell line.Hep G2 is a perpetual cell line which was derived from the liver tissue of a 15-year-old Caucasian American male with a well-differentiated hepatocellular carcinoma. These cells are epithelial in morphology, have a modal chromosome number of 55, and are not tumorigenic in nude mice. The cells secrete a variety of major plasma proteins, e.g., albumin, transferrin, and the acute-phase proteins fibrinogen, alpha 2-macroglobulin, alpha 1-antitrypsin, transferrin, and plasminogen. They have been grown successfully in large-scale cultivation systems. Hepatitis B virus surface antigens have not been detected. HepG2 will respond to stimulation with human growth hormone.HepG2 cells are a suitable in vitro model system for the study of polarized human hepatocytes. (Another well-characterized polarized hepatocyte cell line is the rat hepatoma-derived hybrid cell line WIF-B). With the proper culture conditions, HepG2 cells display robust morphological and functional differentiation with a controllable formation of apical and basolateral cell surface domains (van IJzendoorn et al., 1997; 2000, etc.) that resemble the bile canalicular (BC) and sinusoidal domains, respectively, in vivo.Because of their high degree of morphological and functional differentiation in vitro, HepG2 cells are a suitable model to study the intracellular trafficking and dynamics of bile canalicular and sinusoidal membrane proteins and lipids in human hepatocytes in vitro. This can be important for the study of human liver diseases that are caused by an incorrect subcellular distribution of cell surface proteins, e.g., hepatocanalicular transport defects such as Dubin-Johnson Syndrome and progressive familial intrahepatic cholestasis (PFIC), and familial hypercholesterolemia. HepG2 cells and their derivatives are also used as a model system for studies of liver metabolism and toxicity of xenobiotics, the detection of environmental and dietary cytotoxic and genotoxic (and thus cytoprotective, anti-genotoxic, and cogenotoxic) agents, understanding hepatocarcinogenesis, and for drug targeting studies. HepG2 cells are also employed in trials with bio-artificial liver devices.".
- Hep_G2 thumbnail HepG2.jpg?width=300.
- Hep_G2 wikiPageExternalLink hep-g2.html.
- Hep_G2 wikiPageExternalLink CVCL_0027.
- Hep_G2 wikiPageExternalLink HB-8065.aspx.
- Hep_G2 wikiPageExternalLink S0046817709002524.
- Hep_G2 wikiPageExternalLink 85011430?lang=en®ion=SG.
- Hep_G2 wikiPageID "844190".
- Hep_G2 wikiPageLength "4321".
- Hep_G2 wikiPageOutDegree "18".
- Hep_G2 wikiPageRevisionID "705114860".
- Hep_G2 wikiPageWikiLink Albumin.
- Hep_G2 wikiPageWikiLink Alpha-1_antitrypsin.
- Hep_G2 wikiPageWikiLink Alpha-2-Macroglobulin.
- Hep_G2 wikiPageWikiLink Biological_immortality.
- Hep_G2 wikiPageWikiLink Category:Human_cell_lines.
- Hep_G2 wikiPageWikiLink Cytotoxicity.
- Hep_G2 wikiPageWikiLink Epithelium.
- Hep_G2 wikiPageWikiLink Fibrinogen.
- Hep_G2 wikiPageWikiLink File:HepG2.jpg.
- Hep_G2 wikiPageWikiLink Genotoxicity.
- Hep_G2 wikiPageWikiLink Growth_hormone.
- Hep_G2 wikiPageWikiLink Hepatitis_B.
- Hep_G2 wikiPageWikiLink Immortalised_cell_line.
- Hep_G2 wikiPageWikiLink Plasmin.
- Hep_G2 wikiPageWikiLink Ploidy.
- Hep_G2 wikiPageWikiLink Transferrin.
- Hep_G2 wikiPageWikiLink Xenobiotic.
- Hep_G2 wikiPageWikiLinkText "Hep G2".
- Hep_G2 wikiPageWikiLinkText "HepG2".
- Hep_G2 wikiPageUsesTemplate Template:Citation_needed.
- Hep_G2 subject Category:Human_cell_lines.
- Hep_G2 hypernym G.
- Hep_G2 type Device.
- Hep_G2 type Line.
- Hep_G2 comment "Hep G2 is a human liver cancer cell line.Hep G2 is a perpetual cell line which was derived from the liver tissue of a 15-year-old Caucasian American male with a well-differentiated hepatocellular carcinoma. These cells are epithelial in morphology, have a modal chromosome number of 55, and are not tumorigenic in nude mice.".
- Hep_G2 label "Hep G2".
- Hep_G2 sameAs Q5731621.
- Hep_G2 sameAs m.03gcfc.
- Hep_G2 sameAs Q5731621.
- Hep_G2 wasDerivedFrom Hep_G2?oldid=705114860.
- Hep_G2 depiction HepG2.jpg.
- Hep_G2 isPrimaryTopicOf Hep_G2.