Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Heat_stabilization> ?p ?o }
Showing triples 1 to 37 of
37
with 100 triples per page.
- Heat_stabilization abstract "Heat stabilization is an additive-free preservation technology for tissue samples which stops degradation and changes immediately and permanently. Heat stabilization uses rapid conductive heating, under controlled pressure, to generate a fast, homogenous and irreversible thermal denaturation of proteins, resulting in a complete and permanent elimination of all enzymatic activity that would otherwise cause further biological changes to the tissue sample ex vivo. Due to the permanent inactivation of enzymes, heat stabilization overcomes the drawbacks of conventional tissue sample preservation techniques, such as snap-freezing followed by inhibitors.Understanding the role of proteins, peptides and small molecules in normal and diseased tissue is crucial to defining their potential use as drugs, drug targets or disease biomarkers. Yet biological changes begin the moment tissue is removed from its native environment. Dramatic alterations at the molecular level occur within seconds e.g. changed metabolism, catabolic fragmentation of large molecules (such as ATP) occurs in order to release energy, leading to disrupted control mechanisms, phosphorylation states are altered and proteins begin to degrade. As a consequence vital information may be lost or distorted, leading to inter-sample variation, risk of incorrect data interpretation and potentially misleading conclusions.Heat stabilization offers significant advantages over conventional approaches to preventing biological change. It can be used to replace snap freezing followed by inhibitors, pH changes, organic solvents or cross-linking. It can also be used with frozen tissue, allowing stabilization of stored samples.Heat stabilization can be used for almost any kind of tissue sample, and has been verified to be compatible with many downstream analytical techniques such as mass spectrometry, phospho-shotgun, MALDI imaging, Western blot, 1D and 2D gels, reversed-phased protein arrays, RIA and ELISA.".
- Heat_stabilization wikiPageID "14161546".
- Heat_stabilization wikiPageLength "3625".
- Heat_stabilization wikiPageOutDegree "15".
- Heat_stabilization wikiPageRevisionID "666386261".
- Heat_stabilization wikiPageWikiLink Adenosine_triphosphate.
- Heat_stabilization wikiPageWikiLink Biomarker.
- Heat_stabilization wikiPageWikiLink Category:Proteomics.
- Heat_stabilization wikiPageWikiLink Category:Scientific_techniques.
- Heat_stabilization wikiPageWikiLink ELISA.
- Heat_stabilization wikiPageWikiLink MALDI_imaging.
- Heat_stabilization wikiPageWikiLink Mass_spectrometry.
- Heat_stabilization wikiPageWikiLink Peptide.
- Heat_stabilization wikiPageWikiLink Phosphorylation.
- Heat_stabilization wikiPageWikiLink Protein.
- Heat_stabilization wikiPageWikiLink Radioimmunoassay.
- Heat_stabilization wikiPageWikiLink Shotgun_proteomics.
- Heat_stabilization wikiPageWikiLink Small_molecule.
- Heat_stabilization wikiPageWikiLink Two-dimensional_gel_electrophoresis.
- Heat_stabilization wikiPageWikiLink Western_blot.
- Heat_stabilization wikiPageWikiLinkText "Heat stabilization".
- Heat_stabilization wikiPageWikiLinkText "protein stability".
- Heat_stabilization wikiPageUsesTemplate Template:About.
- Heat_stabilization wikiPageUsesTemplate Template:Reflist.
- Heat_stabilization subject Category:Proteomics.
- Heat_stabilization subject Category:Scientific_techniques.
- Heat_stabilization hypernym Technology.
- Heat_stabilization type Company.
- Heat_stabilization type Company.
- Heat_stabilization comment "Heat stabilization is an additive-free preservation technology for tissue samples which stops degradation and changes immediately and permanently. Heat stabilization uses rapid conductive heating, under controlled pressure, to generate a fast, homogenous and irreversible thermal denaturation of proteins, resulting in a complete and permanent elimination of all enzymatic activity that would otherwise cause further biological changes to the tissue sample ex vivo.".
- Heat_stabilization label "Heat stabilization".
- Heat_stabilization sameAs Q5256594.
- Heat_stabilization sameAs Hitzestabilisierung.
- Heat_stabilization sameAs m.080nc9z.
- Heat_stabilization sameAs Q5256594.
- Heat_stabilization wasDerivedFrom Heat_stabilization?oldid=666386261.
- Heat_stabilization isPrimaryTopicOf Heat_stabilization.