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- Head_and_neck_squamous-cell_carcinoma abstract "Head and neck cancers are malignant neoplasms that arise in the head and region which comprises nasal cavity, paranasal sinuses, oral cavity, salivary glands, pharynx, and larynx. The majority of head and neck cancers histologically belong to squamous-cell type and hence they are categorized as Head and Neck Squamous-cell carcinoma, abbreviated as HNSCC (Forastiere AA, 2003). HNSCC is the sixth most common type of cancer world-wide and account for ~ 5% of all malignancies world-wide (Ferlay J, 2010) and 3% of all malignancies in the United States (Siegel R, 2014). Risk factors include tobacco consumption (chewing or smoking), alcohol consumption, human papilloma virus (HPV) infections (esp. HPV 16, 18), betel nut chewing, wood dust exposures and others (NCI Factsheet, 2013). Symptoms include lump or sore, sore throat, hoarse of voice, difficulty in swallowing etc (NCI Factsheet, 2013). Treatment for HNSCC is based on the stage of the disease. Standard of care for HNSCC includes one or combination of the following: surgery, radiation, chemotherapeutic agents such as Cisplatin, 5-Flurouracil (5-FU) etc. Molecularly targeted therapies were developed since the discovery of role of epidermal growth factor receptor (EGFR) signaling in HNSCC development, progression and prognosis. These targeted therapies include monoclonal antibodies (such as cetuximab, panitumumab etc.) and tyrosine kinase inhibitors (such as erlotinib, gefitinib, etc.). Among these EGFR-targeting agents, only cetuximab has been approved by FDA in 2006 for HNSCC treatment.Ninety percent of cases of head and neck cancer (cancer of the mouth, nasal cavity, nasopharynx, throat and associated structures) are due to squamous cell carcinoma. Symptoms may include a poorly healing mouth ulcer, a hoarse voice or other persistent problems in the area. Treatment is usually with surgery (which may be extensive) and radiotherapy. Risk factors include smoking, alcohol consumption and hematopoietic stem cell transplantation. In addition, recent studies show that about 25% of mouth and 35% of throat cancers are associated with HPV. The 5 year disease free survival rate for HPV positive cancer is significantly higher when appropriately treated with surgery, radiation and chemotherapy as compared to non-HPV positive cancer, substantiated by multiple studies including research conducted by Maura Gillison, et al. of Johns Hopkins Sidney Kimmel Cancer Center.".
- Head_and_neck_squamous-cell_carcinoma thumbnail Oral_cancer_(1)_squamous_cell_carcinoma_histopathology.jpg?width=300.
- Head_and_neck_squamous-cell_carcinoma wikiPageID "44120142".
- Head_and_neck_squamous-cell_carcinoma wikiPageLength "3428".
- Head_and_neck_squamous-cell_carcinoma wikiPageOutDegree "21".
- Head_and_neck_squamous-cell_carcinoma wikiPageRevisionID "678853581".
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Alcoholic_beverage.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Areca_nut.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Category:Anatomical_pathology.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Category:Carcinoma.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Cetuximab.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Epidermal_growth_factor_receptor.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Erlotinib.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Food_and_Drug_Administration.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Gefitinib.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Head_and_neck_cancer.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Hematopoietic_stem_cell_transplantation.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Mouth_ulcer.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Neoplasm.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Panitumumab.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Radiation_therapy.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Squamous-cell_carcinoma.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Surgery.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Tobacco_smoking.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink Tyrosine-kinase_inhibitor.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLink File:Oral_cancer_(1)_squamous_cell_carcinoma_histopathology.jpg.
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLinkText "Head and neck squamous-cell carcinoma".
- Head_and_neck_squamous-cell_carcinoma wikiPageWikiLinkText "head and neck squamous-cell carcinoma".
- Head_and_neck_squamous-cell_carcinoma wikiPageUsesTemplate Template:Reflist.
- Head_and_neck_squamous-cell_carcinoma subject Category:Anatomical_pathology.
- Head_and_neck_squamous-cell_carcinoma subject Category:Carcinoma.
- Head_and_neck_squamous-cell_carcinoma hypernym Neoplasms.
- Head_and_neck_squamous-cell_carcinoma type Disease.
- Head_and_neck_squamous-cell_carcinoma comment "Head and neck cancers are malignant neoplasms that arise in the head and region which comprises nasal cavity, paranasal sinuses, oral cavity, salivary glands, pharynx, and larynx. The majority of head and neck cancers histologically belong to squamous-cell type and hence they are categorized as Head and Neck Squamous-cell carcinoma, abbreviated as HNSCC (Forastiere AA, 2003).".
- Head_and_neck_squamous-cell_carcinoma label "Head and neck squamous-cell carcinoma".
- Head_and_neck_squamous-cell_carcinoma sameAs Q18348812.
- Head_and_neck_squamous-cell_carcinoma sameAs m.0123nq_d.
- Head_and_neck_squamous-cell_carcinoma sameAs Q18348812.
- Head_and_neck_squamous-cell_carcinoma wasDerivedFrom Head_and_neck_squamous-cell_carcinoma?oldid=678853581.
- Head_and_neck_squamous-cell_carcinoma depiction Oral_cancer_(1)_squamous_cell_carcinoma_histopathology.jpg.
- Head_and_neck_squamous-cell_carcinoma isPrimaryTopicOf Head_and_neck_squamous-cell_carcinoma.