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- Happy_mapping abstract "In genetics, HAPPY Mapping, first proposed by Paul H. Dear and Peter R. Cook in 1989, is a method used to study the linkage between two or more DNA sequences. According to the Single Molecule Genomics Group, it is \"Mapping based on the analysis of approximately HAPloid DNA samples using the PolYmerase chain reaction\". In genomics, HAPPY mapping can be applied to assess the synteny and orientation of various DNA sequences across a particular genome - the generation of a \"genomic\" map. As with linkage mapping, HAPPY mapping relies on the differential probability of two or more DNA sequences being separated. In genetic mapping, the probability of a recombination event between two genetic loci on the same chromosome is directly proportional to the distance between them. HAPPY mapping replaces recombination with fragmentation - instead of relying on recombination to separate genetic loci, the entire genome is fragmented, for example, by radiation or mechanical shearing. If the DNA is broken on a random basis, the longer the distance between two DNA sequences, the higher the chances of it to break between the two, and vice versa.HAPPY mapping retains the benefits of genetic mapping while removing some of the problems associated with recombination. I.e., the need for polymorphism, and breeding. Also, recombination can be locale specific whereas breakage of genomic DNA by radiation or mechanical shearing seems to be more random. It has been used to genetically map several organisms.HAPPY mapping has also been adapted to allow the precise analysis of copy-number variation, and in particular the analysis of copy-number changes in cancer.".
- Happy_mapping wikiPageExternalLink happyhomepage.html.
- Happy_mapping wikiPageID "6513609".
- Happy_mapping wikiPageLength "3287".
- Happy_mapping wikiPageOutDegree "13".
- Happy_mapping wikiPageRevisionID "687298974".
- Happy_mapping wikiPageWikiLink Category:Genetic_mapping.
- Happy_mapping wikiPageWikiLink Category:Genomics.
- Happy_mapping wikiPageWikiLink Chromosome.
- Happy_mapping wikiPageWikiLink Copy_number_analysis.
- Happy_mapping wikiPageWikiLink Genetic_linkage.
- Happy_mapping wikiPageWikiLink Genetic_recombination.
- Happy_mapping wikiPageWikiLink Genetics.
- Happy_mapping wikiPageWikiLink Genomics.
- Happy_mapping wikiPageWikiLink Locus_(genetics).
- Happy_mapping wikiPageWikiLink Nucleic_acid_sequence.
- Happy_mapping wikiPageWikiLink Polymorphism_(biology).
- Happy_mapping wikiPageWikiLink Synteny.
- Happy_mapping wikiPageWikiLinkText "Happy mapping".
- Happy_mapping wikiPageWikiLinkText "hap-mapping".
- Happy_mapping wikiPageUsesTemplate Template:Reflist.
- Happy_mapping subject Category:Genetic_mapping.
- Happy_mapping subject Category:Genomics.
- Happy_mapping hypernym Method.
- Happy_mapping type Software.
- Happy_mapping type Genomic.
- Happy_mapping type Omic.
- Happy_mapping comment "In genetics, HAPPY Mapping, first proposed by Paul H. Dear and Peter R. Cook in 1989, is a method used to study the linkage between two or more DNA sequences. According to the Single Molecule Genomics Group, it is \"Mapping based on the analysis of approximately HAPloid DNA samples using the PolYmerase chain reaction\". In genomics, HAPPY mapping can be applied to assess the synteny and orientation of various DNA sequences across a particular genome - the generation of a \"genomic\" map.".
- Happy_mapping label "Happy mapping".
- Happy_mapping sameAs Q17141848.
- Happy_mapping sameAs Happy_mapping.
- Happy_mapping sameAs m.0g87jx.
- Happy_mapping sameAs Q17141848.
- Happy_mapping wasDerivedFrom Happy_mapping?oldid=687298974.
- Happy_mapping isPrimaryTopicOf Happy_mapping.