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- HVCN1 abstract "Voltage-gated hydrogen channel 1 is a protein that in humans is encoded by the HVCN1 gene.Voltage-gated hydrogen channel 1 is a voltage-gated proton channel that has been shown to allow proton transport into phagosomes and out of many types of cells including spermatozoa, electrically excitable cells and respiratory epithelial cells. The proton-conducting HVCN1 channel has only transmembrane domains corresponding to the S1-S4 voltage sensing domains (VSD) of voltage-gated potassium channels and voltage-gated sodium channels. Molecular simulation is consistent with a water-filled pore that can function as a \"water wire\" for allowing hydrogen bonded H+ to cross the membrane. However, mutation of Asp112 in human Hv1 results in anion permeation, suggesting that obligatory protonation of Asp produces proton selectivity. Quantum mechanical calculations show that the Asp-Arg interaction can produce proton selective permeation. The HVCN1 protein has been shown to exist as a dimer with two functioning pores. Like other VSD channels, HVCN1 channels conduct ions about 1000-fold slower than channels formed by tetrameric S5-S6 central pores.".
- HVCN1 entrezgene "84329".
- HVCN1 wikiPageID "33110155".
- HVCN1 wikiPageLength "11020".
- HVCN1 wikiPageOutDegree "14".
- HVCN1 wikiPageRevisionID "704337432".
- HVCN1 wikiPageWikiLink Action_potential.
- HVCN1 wikiPageWikiLink Anti-inflammatory.
- HVCN1 wikiPageWikiLink Category:Ion_channels.
- HVCN1 wikiPageWikiLink Chemotherapy.
- HVCN1 wikiPageWikiLink Gene.
- HVCN1 wikiPageWikiLink Grotthuss_mechanism.
- HVCN1 wikiPageWikiLink Phagosome.
- HVCN1 wikiPageWikiLink Protein.
- HVCN1 wikiPageWikiLink Respiratory_epithelium.
- HVCN1 wikiPageWikiLink Small_molecule.
- HVCN1 wikiPageWikiLink Sodium_channel.
- HVCN1 wikiPageWikiLink Spermatozoon.
- HVCN1 wikiPageWikiLink Voltage-gated_potassium_channel.
- HVCN1 wikiPageWikiLink Voltage-gated_proton_channel.
- HVCN1 wikiPageWikiLinkText "HVCN1".
- HVCN1 wikiPageUsesTemplate Template:Cite_journal.
- HVCN1 wikiPageUsesTemplate Template:Ion_channels.
- HVCN1 wikiPageUsesTemplate Template:PBB.
- HVCN1 wikiPageUsesTemplate Template:Refbegin.
- HVCN1 wikiPageUsesTemplate Template:Refend.
- HVCN1 wikiPageUsesTemplate Template:Reflist.
- HVCN1 subject Category:Ion_channels.
- HVCN1 hypernym Protein.
- HVCN1 type Biomolecule.
- HVCN1 type Protein.
- HVCN1 type Biophysic.
- HVCN1 type Channel.
- HVCN1 type Thing.
- HVCN1 type Q206229.
- HVCN1 type Q8054.
- HVCN1 comment "Voltage-gated hydrogen channel 1 is a protein that in humans is encoded by the HVCN1 gene.Voltage-gated hydrogen channel 1 is a voltage-gated proton channel that has been shown to allow proton transport into phagosomes and out of many types of cells including spermatozoa, electrically excitable cells and respiratory epithelial cells.".
- HVCN1 label "HVCN1".
- HVCN1 sameAs Q18047575.
- HVCN1 sameAs m.0h6501b.
- HVCN1 sameAs Q18047575.
- HVCN1 wasDerivedFrom HVCN1?oldid=704337432.
- HVCN1 isPrimaryTopicOf HVCN1.