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- HOTTIP abstract "In molecular biology, HOTTIP (HOXA transcript at the distal tip) is a long non-coding RNA. The gene encoding HOTTIP is located at the 5' tip of the HOXA locus, and coordinates the activation of several of the 5' HOXA genes. The non-coding RNA is brought into close proximity with the HOXA genes by chromosomal looping. HOTTIP binds to the WDR5 protein, which forms a complex with the histone methyltransferase protein MLL. This targets the WDR5-MLL complex to the HOXA region and results in H3K4 methylation and transcriptional activation of the HOXA locus.More recently, HOTTIP has been shown to play a role in Hepatocellular Carcinoma (HCC) progression. HOTTIP expression levels predict metastasis formation and poor disease outcome in HCC patients. Long noncoding RNA↑ ↑".
- HOTTIP wikiPageExternalLink cite&retmode=ref&cmd=prlinks&id=21483457.
- HOTTIP wikiPageID "32147903".
- HOTTIP wikiPageLength "2188".
- HOTTIP wikiPageOutDegree "11".
- HOTTIP wikiPageRevisionID "678850575".
- HOTTIP wikiPageWikiLink Category:Non-coding_RNA.
- HOTTIP wikiPageWikiLink Chromosome.
- HOTTIP wikiPageWikiLink Directionality_(molecular_biology).
- HOTTIP wikiPageWikiLink Histone_methyltransferase.
- HOTTIP wikiPageWikiLink Hox_gene.
- HOTTIP wikiPageWikiLink KMT2A.
- HOTTIP wikiPageWikiLink Long_non-coding_RNA.
- HOTTIP wikiPageWikiLink Molecular_biology.
- HOTTIP wikiPageWikiLink Regulation_of_gene_expression.
- HOTTIP wikiPageWikiLink WDR5.
- HOTTIP wikiPageWikiLinkText "HOTTIP".
- HOTTIP wikiPageUsesTemplate Template:Cite_journal.
- HOTTIP wikiPageUsesTemplate Template:Reflist.
- HOTTIP subject Category:Non-coding_RNA.
- HOTTIP hypernym RNA.
- HOTTIP type Protein.
- HOTTIP comment "In molecular biology, HOTTIP (HOXA transcript at the distal tip) is a long non-coding RNA. The gene encoding HOTTIP is located at the 5' tip of the HOXA locus, and coordinates the activation of several of the 5' HOXA genes. The non-coding RNA is brought into close proximity with the HOXA genes by chromosomal looping. HOTTIP binds to the WDR5 protein, which forms a complex with the histone methyltransferase protein MLL.".
- HOTTIP label "HOTTIP".
- HOTTIP sameAs Q17125763.
- HOTTIP sameAs m.0gw_qrj.
- HOTTIP sameAs Q17125763.
- HOTTIP wasDerivedFrom HOTTIP?oldid=678850575.
- HOTTIP isPrimaryTopicOf HOTTIP.