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- HMB-45 abstract "HMB-45 is a monoclonal antibody that reacts against an antigen present in melanocytic tumors such as melanomas, and stands for human melanoma black 45. It is used in anatomic pathology as a marker for such tumors. The specific antigen recognized by HMB-45 is now known as Pmel 17.HMB-45 was discovered by Drs. Allen M. Gown and Arthur M. Vogel in 1986. The antibody was generated to an extract of melanoma. It reacts positively against melanocytic tumors but not other tumors, thus demonstrating specificity and sensitivity.In a study to determine diagnostic usefulness of specific antibodies used to identify melanoma, HMB-45 had a 92% sensitivity when used to identify melanoma. The antibody also reacts positively against junctional nevus cells and fetal melanocytes.Despite this relatively high sensitivity—HMB-45 does have its drawbacks. HMB-45 can be detected in only 50-70% of melanomas. HMB-45 does not react well against intradermal nevi, normal adult melanocytes, spindle cell melanomas and desmoplastic melanomas. HMB-45 is nonreactive with almost all non-melanoma human malignancies, with the exception of rare tumors showing evidence of melanogenesis (e.g., pigmented schwannoma, clear cell sarcoma) or tumors associated with tuberous sclerosis complex (angiomyolipoma and lymphangiomyoma).StorageHMB-45 should be stored at 4 degree Celsius. At 4 degrees Celsius the antibody will be stable for up to 2 months without any loss of quality. For best results it should be used before the expiration date.Other AntibodiesWhen conducting an immunocytochemical studies to identify melanoma for scientific or clinical studies, scientist and medical professionals can also use S-100, Melan-A, Tyrosinase, and Mitf to identify tumors.".
- HMB-45 wikiPageExternalLink index.html?datasheet=787.
- HMB-45 wikiPageExternalLink 12472287.
- HMB-45 wikiPageExternalLink PMEL17-SILV-Antibody-HMB45_NBP2-29418.html.
- HMB-45 wikiPageExternalLink datasheet-59305-melanoma-marker-hmb45-antibody.html.
- HMB-45 wikiPageID "3447944".
- HMB-45 wikiPageLength "3300".
- HMB-45 wikiPageOutDegree "14".
- HMB-45 wikiPageRevisionID "686935274".
- HMB-45 wikiPageWikiLink Abcam.
- HMB-45 wikiPageWikiLink Anatomical_pathology.
- HMB-45 wikiPageWikiLink Angiomyolipoma.
- HMB-45 wikiPageWikiLink Category:Histopathology.
- HMB-45 wikiPageWikiLink List_of_histologic_stains_that_aid_in_diagnosis_of_cutaneous_conditions.
- HMB-45 wikiPageWikiLink Lymphangiomyoma.
- HMB-45 wikiPageWikiLink Melanocyte.
- HMB-45 wikiPageWikiLink Melanoma.
- HMB-45 wikiPageWikiLink Monoclonal_antibody.
- HMB-45 wikiPageWikiLink Neoplasm.
- HMB-45 wikiPageWikiLink Nevus.
- HMB-45 wikiPageWikiLink Sarcoma.
- HMB-45 wikiPageWikiLink Schwannoma.
- HMB-45 wikiPageWikiLink Tuberous_sclerosis.
- HMB-45 wikiPageWikiLinkText "HMB-45".
- HMB-45 wikiPageUsesTemplate Template:Pathology-stub.
- HMB-45 subject Category:Histopathology.
- HMB-45 hypernym Antibody.
- HMB-45 type Drug.
- HMB-45 type Redirect.
- HMB-45 comment "HMB-45 is a monoclonal antibody that reacts against an antigen present in melanocytic tumors such as melanomas, and stands for human melanoma black 45. It is used in anatomic pathology as a marker for such tumors. The specific antigen recognized by HMB-45 is now known as Pmel 17.HMB-45 was discovered by Drs. Allen M. Gown and Arthur M. Vogel in 1986. The antibody was generated to an extract of melanoma.".
- HMB-45 label "HMB-45".
- HMB-45 sameAs Q5630684.
- HMB-45 sameAs m.09cywx.
- HMB-45 sameAs Q5630684.
- HMB-45 wasDerivedFrom HMB-45?oldid=686935274.
- HMB-45 isPrimaryTopicOf HMB-45.