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- HLA-DQ8 abstract "HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 broad antigen. DQ8 is determined by the antibody recognition of β8 and this generally detects the gene product of DQB1*0302.DQ8 is commonly linked to autoimmune disease in the human population. DQ8 is the second most predominant isoform linked to coeliac disease and the DQ most linked to juvenile diabetes. DQ8 increases the risk for rheumatoid arthritis and is linked to the primary risk locus for RA, HLA-DR4. DR4 also plays an important role in juvenile diabetes. While the DQ8.1 haplotype is associated with disease, there is no known association with the DQB1*0305, DQ8.4 or DQ8.5 haplotypes (see infobox) with autoimmune disease; however, this may be the result of lack of study in populations that carry these and the very low frequency.DQ8.1 also differs from other HLA in population frequencies. Typically for MHC Class II antigens in humans, haplotype frequencies do not exceed 40%. For example, in the US the highest haplotype frequency, the haplotype that encoded DQ6.2, is around 15%, this translates into phenotype frequencies of less than 30%. Atypically haplotype frequencies exceed 40%.For DQ8 the highest haplotype frequencies approach 80% in parts of Central and South America and the phenotype frequencies approach 90%. This is the highest phenotype frequency observed for any DR or DQ phenotype in the human population by a wide margin.".
- HLA-DQ8 thumbnail HLA-DQ8_insulin.png?width=300.
- HLA-DQ8 wikiPageExternalLink celiac.
- HLA-DQ8 wikiPageExternalLink www.celiac.org.
- HLA-DQ8 wikiPageExternalLink www.celiacawareness.org.
- HLA-DQ8 wikiPageExternalLink www.celiaccenter.org.
- HLA-DQ8 wikiPageExternalLink www.childrenwithdiabetes.com.
- HLA-DQ8 wikiPageExternalLink www.coeliac.co.uk.
- HLA-DQ8 wikiPageExternalLink www.csaceliacs.org.
- HLA-DQ8 wikiPageExternalLink type-1-diabetes.jsp.
- HLA-DQ8 wikiPageID "7649285".
- HLA-DQ8 wikiPageLength "68551".
- HLA-DQ8 wikiPageOutDegree "29".
- HLA-DQ8 wikiPageRevisionID "705769232".
- HLA-DQ8 wikiPageWikiLink American_Diabetes_Association.
- HLA-DQ8 wikiPageWikiLink Autoimmune_disease.
- HLA-DQ8 wikiPageWikiLink Category:HLA-DQ_haplotypes.
- HLA-DQ8 wikiPageWikiLink Category:Human_MHC_mediated_diseases.
- HLA-DQ8 wikiPageWikiLink Coeliac_disease.
- HLA-DQ8 wikiPageWikiLink Diabetes_mellitus_type_1.
- HLA-DQ8 wikiPageWikiLink European_Bioinformatics_Institute.
- HLA-DQ8 wikiPageWikiLink File:DQ8-Insulin_peptide.PNG.
- HLA-DQ8 wikiPageWikiLink HLA-DQ.
- HLA-DQ8 wikiPageWikiLink HLA-DQ3.
- HLA-DQ8 wikiPageWikiLink HLA-DQB1.
- HLA-DQ8 wikiPageWikiLink HLA-DR4.
- HLA-DQ8 wikiPageWikiLink HLA_Informatics_Group.
- HLA-DQ8 wikiPageWikiLink Human_leukocyte_antigen.
- HLA-DQ8 wikiPageWikiLink MHC_class_II.
- HLA-DQ8 wikiPageWikiLink Major_histocompatibility_complex,_class_II,_DQ_alpha_1.
- HLA-DQ8 wikiPageWikiLink Rheumatoid_arthritis.
- HLA-DQ8 wikiPageWikiLink Rio_Grande.
- HLA-DQ8 wikiPageWikiLink Serotype.
- HLA-DQ8 wikiPageWikiLink Triticeae.
- HLA-DQ8 wikiPageWikiLink Wikt:broad_antigen.
- HLA-DQ8 wikiPageWikiLink Wikt:cis.
- HLA-DQ8 wikiPageWikiLink Wikt:haplotype.
- HLA-DQ8 wikiPageWikiLink Wikt:isoform.
- HLA-DQ8 wikiPageWikiLink Wikt:split_antigen.
- HLA-DQ8 wikiPageWikiLinkText "*0302".
- HLA-DQ8 wikiPageWikiLinkText "*0305".
- HLA-DQ8 wikiPageWikiLinkText "DQ8".
- HLA-DQ8 wikiPageWikiLinkText "DQ8.1".
- HLA-DQ8 wikiPageWikiLinkText "HLA-DQ8".
- HLA-DQ8 wikiPageWikiLinkText "HLA-DQ8#DQ8.1".
- HLA-DQ8 allele1b "[[#DQB1*0302".
- HLA-DQ8 allele2b "*0302".
- HLA-DQ8 imageSource "Rendering of HLA-DQ8 with immundoinant insulin peptide in the binding pocket.".
- HLA-DQ8 isoform "DQ α3β8".
- HLA-DQ8 isoformcount "2".
- HLA-DQ8 isoformgroup "HLA-DQ8".
- HLA-DQ8 nick "DQ8.1v".
- HLA-DQ8 nick "[[#DQ8.1".
- HLA-DQ8 polymerType "MHC Class II, DQ cell surface antigen".
- HLA-DQ8 rallele1b "*0302".
- HLA-DQ8 rallele2b "*0302".
- HLA-DQ8 rareisoforms "2".
- HLA-DQ8 risoform "DQ α4β8".
- HLA-DQ8 risoform "DQ α5β8".
- HLA-DQ8 rnick "DQ8.4".
- HLA-DQ8 rnick "DQ8.5".
- HLA-DQ8 subunit HLA-DQB1.
- HLA-DQ8 subunit Major_histocompatibility_complex,_class_II,_DQ_alpha_1.
- HLA-DQ8 wikiPageUsesTemplate Template:Clear.
- HLA-DQ8 wikiPageUsesTemplate Template:Clear_left.
- HLA-DQ8 wikiPageUsesTemplate Template:Clear_right.
- HLA-DQ8 wikiPageUsesTemplate Template:Color.
- HLA-DQ8 wikiPageUsesTemplate Template:DQ_serotypes.
- HLA-DQ8 wikiPageUsesTemplate Template:Gluten_sensitivity.
- HLA-DQ8 wikiPageUsesTemplate Template:HQAA.
- HLA-DQ8 wikiPageUsesTemplate Template:HQBA.
- HLA-DQ8 wikiPageUsesTemplate Template:Infobox_heteroisoform.
- HLA-DQ8 wikiPageUsesTemplate Template:Reflist.
- HLA-DQ8 subject Category:HLA-DQ_haplotypes.
- HLA-DQ8 subject Category:Human_MHC_mediated_diseases.
- HLA-DQ8 hypernym Serotype.
- HLA-DQ8 type Species.
- HLA-DQ8 type Disorder.
- HLA-DQ8 comment "HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 broad antigen. DQ8 is determined by the antibody recognition of β8 and this generally detects the gene product of DQB1*0302.DQ8 is commonly linked to autoimmune disease in the human population. DQ8 is the second most predominant isoform linked to coeliac disease and the DQ most linked to juvenile diabetes.".
- HLA-DQ8 label "HLA-DQ8".
- HLA-DQ8 sameAs Q5630156.
- HLA-DQ8 sameAs m.0267tyv.
- HLA-DQ8 sameAs Q5630156.
- HLA-DQ8 wasDerivedFrom HLA-DQ8?oldid=705769232.
- HLA-DQ8 depiction HLA-DQ8_insulin.png.
- HLA-DQ8 isPrimaryTopicOf HLA-DQ8.