Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/HLA-DQ> ?p ?o }
- HLA-DQ abstract "HLA-DQ (DQ) is a cell surface receptor protein found on antigen presenting cells. It is an αβ heterodimer of type MHC Class II. The α and β chains are encoded by the two loci HLA-DQA1 and HLA-DQB1, respectively, which are adjacent to each other on chromosome 6p21.3. Both α-chain and β-chain vary greatly. A person often produces two α-chain and two β-chain variants and thus 4 isoforms of DQ. The DQ loci are in close genetic linkage to HLA-DR, and less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C.Different isoforms of DQ can bind to and present different antigens to T-cells. In this process T-cells are stimulated to grow and can signal B-cells to produce antibodies. DQ functions in recognizing and presenting foreign antigens (proteins derived from potential pathogens). But DQ is also involved in recognizing common self-antigens and presenting those antigens to the immune system in order to develop tolerance from a very young age.When tolerance to self proteins is lost, DQ may become involved in autoimmune disease. Two autoimmune diseases in which HLA-DQ is involved are coeliac disease and diabetes mellitus type 1. DQ is one of several antigens involved in rejection of organ transplants. As a variable cell surface receptor on immune cells, these D antigens, originally HL-A4 antigens, are involved in graft versus host disease when lymphoid tissues are transplanted between people. Serological studies of DQ recognized that antibodies to DQ bind primarily to the β-chain. The currently used serotypes are HLA-DQ2, -DQ3, -DQ4, -DQ5, -DQ6, -DQ7, -DQ8, -DQ9. HLA-DQ1 is a weak reaction to the α-chain and was replaced by DQ5 and DQ6 serology. Serotyping is capable of identifying most aspects of DQ isoform structure and function, however sequence specific PCR is now the preferred method of determining HLA-DQA1 and HLA-DQB1 alleles, as serotyping cannot resolve, often, the critical contribution of the DQ α-chain. This can be compensated for by examining DR serotypes as well as DQ serotypes.".
- HLA-DQ thumbnail DQ_Illustration.PNG?width=300.
- HLA-DQ wikiPageExternalLink hla.
- HLA-DQ wikiPageExternalLink mmdbsrv.cgi?Dopt=s&uid=17145.
- HLA-DQ wikiPageExternalLink www.allelefrequencies.net.
- HLA-DQ wikiPageID "7194104".
- HLA-DQ wikiPageLength "34859".
- HLA-DQ wikiPageOutDegree "92".
- HLA-DQ wikiPageRevisionID "679145398".
- HLA-DQ wikiPageWikiLink Antibody.
- HLA-DQ wikiPageWikiLink Antigen-presenting_cell.
- HLA-DQ wikiPageWikiLink Autoimmune_disease.
- HLA-DQ wikiPageWikiLink Autoimmunity.
- HLA-DQ wikiPageWikiLink B_cell.
- HLA-DQ wikiPageWikiLink Category:Genes_on_human_chromosome_6.
- HLA-DQ wikiPageWikiLink Category:HLA-DQ_haplotypes.
- HLA-DQ wikiPageWikiLink Category:Human_MHC_mediated_diseases.
- HLA-DQ wikiPageWikiLink Category:MHC_Class_II.
- HLA-DQ wikiPageWikiLink Cell_surface_receptor.
- HLA-DQ wikiPageWikiLink Chromosome.
- HLA-DQ wikiPageWikiLink Chromosome_6_(human).
- HLA-DQ wikiPageWikiLink Cn3D.
- HLA-DQ wikiPageWikiLink Coeliac_disease.
- HLA-DQ wikiPageWikiLink Diabetes_mellitus_type_1.
- HLA-DQ wikiPageWikiLink Genetic_linkage.
- HLA-DQ wikiPageWikiLink Gluten-sensitive_enteropathy-associated_conditions.
- HLA-DQ wikiPageWikiLink Graft-versus-host_disease.
- HLA-DQ wikiPageWikiLink HLA-A.
- HLA-DQ wikiPageWikiLink HLA-B.
- HLA-DQ wikiPageWikiLink HLA-C.
- HLA-DQ wikiPageWikiLink HLA-DP.
- HLA-DQ wikiPageWikiLink HLA-DQ1.
- HLA-DQ wikiPageWikiLink HLA-DQ2.
- HLA-DQ wikiPageWikiLink HLA-DQ3.
- HLA-DQ wikiPageWikiLink HLA-DQ4.
- HLA-DQ wikiPageWikiLink HLA-DQ5.
- HLA-DQ wikiPageWikiLink HLA-DQ6.
- HLA-DQ wikiPageWikiLink HLA-DQ7.
- HLA-DQ wikiPageWikiLink HLA-DQ8.
- HLA-DQ wikiPageWikiLink HLA-DQ9.
- HLA-DQ wikiPageWikiLink HLA-DQB1.
- HLA-DQ wikiPageWikiLink HLA-DR.
- HLA-DQ wikiPageWikiLink Haplotype.
- HLA-DQ wikiPageWikiLink Human_leukocyte_antigen.
- HLA-DQ wikiPageWikiLink Immune_tolerance.
- HLA-DQ wikiPageWikiLink Lymphatic_system.
- HLA-DQ wikiPageWikiLink MHC_class_II.
- HLA-DQ wikiPageWikiLink Major_histocompatibility_complex.
- HLA-DQ wikiPageWikiLink Major_histocompatibility_complex,_class_II,_DQ_alpha_1.
- HLA-DQ wikiPageWikiLink Myasthenia_gravis.
- HLA-DQ wikiPageWikiLink Polymerase_chain_reaction.
- HLA-DQ wikiPageWikiLink Protein.
- HLA-DQ wikiPageWikiLink Protein_dimer.
- HLA-DQ wikiPageWikiLink Protein_isoform.
- HLA-DQ wikiPageWikiLink RasMol.
- HLA-DQ wikiPageWikiLink Serology.
- HLA-DQ wikiPageWikiLink Serotype.
- HLA-DQ wikiPageWikiLink Single-nucleotide_polymorphism.
- HLA-DQ wikiPageWikiLink T_cell.
- HLA-DQ wikiPageWikiLink Transplant_rejection.
- HLA-DQ wikiPageWikiLink White_blood_cell.
- HLA-DQ wikiPageWikiLink Wikt:cis-.
- HLA-DQ wikiPageWikiLink Wikt:isoform.
- HLA-DQ wikiPageWikiLink Wikt:locus.
- HLA-DQ wikiPageWikiLink Wikt:pathogen.
- HLA-DQ wikiPageWikiLink Wikt:trans-.
- HLA-DQ wikiPageWikiLink Wikt:variant.
- HLA-DQ wikiPageWikiLink Zygosity.
- HLA-DQ wikiPageWikiLink File:HLA.svg.
- HLA-DQ wikiPageWikiLink File:TCELL-APC_DQ.png.
- HLA-DQ wikiPageWikiLink Talk:HLA-DQ.
- HLA-DQ wikiPageWikiLinkText "DQ heterodimer".
- HLA-DQ wikiPageWikiLinkText "DQ".
- HLA-DQ wikiPageWikiLinkText "DQ2".
- HLA-DQ wikiPageWikiLinkText "DQ7".
- HLA-DQ wikiPageWikiLinkText "DQA1 and DQB1".
- HLA-DQ wikiPageWikiLinkText "HLA-DQ".
- HLA-DQ function "Immune recognition and".
- HLA-DQ function "antigen presentation".
- HLA-DQ gene HLA-DQB1.
- HLA-DQ gene Major_histocompatibility_complex,_class_II,_DQ_alpha_1.
- HLA-DQ heteropolymer "MHC class II, DQ".
- HLA-DQ imageSource "DQ1 binding pocket with ligand".
- HLA-DQ locus "Chromosome 6p21.31".
- HLA-DQ polymerType "heterodimer".
- HLA-DQ proteinType Cell_surface_receptor.
- HLA-DQ subunit "α".
- HLA-DQ subunit "β".
- HLA-DQ subunitcount "2".
- HLA-DQ wikiPageUsesTemplate Template:DQ_serotypes.
- HLA-DQ wikiPageUsesTemplate Template:Heteropolypeptide.
- HLA-DQ wikiPageUsesTemplate Template:Reflist.
- HLA-DQ wikiPageUsesTemplate Template:Surface_antigens.
- HLA-DQ subject Category:Genes_on_human_chromosome_6.
- HLA-DQ subject Category:HLA-DQ_haplotypes.
- HLA-DQ subject Category:Human_MHC_mediated_diseases.
- HLA-DQ subject Category:MHC_Class_II.
- HLA-DQ hypernym Protein.
- HLA-DQ type Protein.
- HLA-DQ type Disorder.