Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/HLA-A> ?p ?o }
- HLA-A abstract "HLA-A is a group of human leukocyte antigens (HLA) that are coded for by the HLA-A locus, which is located at human chromosome 6p21.3. HLA is simply the major histocompatibility complex (MHC) specific to humans. HLA-A is one of three major types of human MHC class I cell surface receptors. The others are HLA-B and HLA-C. The receptor is a heterodimer, and is composed of a heavy α chain and smaller β chain. The α chain is encoded by a variant HLA-A gene, and the β chain (β2-microglobulin) is an invariant β2 microglobulin molecule. The β2 microglobulin protein is coded for by a separate region of the human genome.MHC Class I molecules such as HLA-A are part of a process that presents short polypeptides to the immune system. These polypeptides are typically 7-11 amino acids in length and originate from proteins being expressed by the cell. There are two classes of polypeptide that can be presented by an HLA protein: those that are supposed to be expressed by the cell (self) and those of foreign derivation (non-self). Under normal conditions cytotoxic T cells, which normally patrol the body in the blood, \"read\" the peptide presented by the complex. T cells, if functioning properly, only bind to non-self peptides. If binding occurs, a series of events is initiated culminating in cell death via apoptosis. In this manner, the human body eliminates any cells infected by a virus or expressing proteins they shouldn't be (e.g. cancerous cells).For humans, as in most mammalian populations, MHC Class I molecules are extremely variable in their primary structure, and HLA-A is ranked among the genes in humans with the fastest-evolving coding sequence. As of December 2013, there are 2432 known HLA-A alleles coding for 1740 active proteins and 117 null proteins. This level of variation on MHC Class I is the primary cause of transplant rejection, as random transplantation between donor and host is unlikely to result in a matching of HLA-A, B or C antigens. Evolutionary biologists also believe that the wide variation in HLAs is a result of a balancing act between conflicting pathogenic pressures. Greater variety of HLAs decreases the probability that the entire population will be wiped out by a single pathogen as certain individuals will be highly resistant to each pathogen. The effect of HLA-A variation on HIV/AIDS progression is discussed here.".
- HLA-A entrezgene "3105".
- HLA-A thumbnail Illustration_HLA-A.png?width=300.
- HLA-A wikiPageExternalLink class1.html.
- HLA-A wikiPageExternalLink DNAanthro.
- HLA-A wikiPageExternalLink www.allelefrequencies.net.
- HLA-A wikiPageExternalLink get_allele.cgi?A*02:02.
- HLA-A wikiPageExternalLink get_allele.cgi?A*02:04.
- HLA-A wikiPageExternalLink get_allele.cgi?A*02:324.
- HLA-A wikiPageExternalLink hgnc_data.php?match=HLA-A.
- HLA-A wikiPageExternalLink 14871896.
- HLA-A wikiPageID "7718899".
- HLA-A wikiPageLength "26442".
- HLA-A wikiPageOutDegree "59".
- HLA-A wikiPageRevisionID "670833330".
- HLA-A wikiPageWikiLink Allele.
- HLA-A wikiPageWikiLink Apoptosis.
- HLA-A wikiPageWikiLink Beta-2_microglobulin.
- HLA-A wikiPageWikiLink Beta_sheet.
- HLA-A wikiPageWikiLink Biomolecular_structure.
- HLA-A wikiPageWikiLink CD8.
- HLA-A wikiPageWikiLink Calnexin.
- HLA-A wikiPageWikiLink Calreticulin.
- HLA-A wikiPageWikiLink Category:Genes_on_human_chromosome_6.
- HLA-A wikiPageWikiLink Category:HLA-A_alleles.
- HLA-A wikiPageWikiLink Cell_surface_receptor.
- HLA-A wikiPageWikiLink Chaperone_(protein).
- HLA-A wikiPageWikiLink Chromosome_15_(human).
- HLA-A wikiPageWikiLink Chromosome_6_(human).
- HLA-A wikiPageWikiLink Cytotoxic_T_cell.
- HLA-A wikiPageWikiLink Endoplasmic_reticulum.
- HLA-A wikiPageWikiLink HIV.
- HLA-A wikiPageWikiLink HLA-A*02.
- HLA-A wikiPageWikiLink HLA-A1.
- HLA-A wikiPageWikiLink HLA-A11.
- HLA-A wikiPageWikiLink HLA-A24.
- HLA-A wikiPageWikiLink HLA-A26.
- HLA-A wikiPageWikiLink HLA-A3.
- HLA-A wikiPageWikiLink HLA-A30.
- HLA-A wikiPageWikiLink HLA-A68.
- HLA-A wikiPageWikiLink HLA-B.
- HLA-A wikiPageWikiLink HLA-C.
- HLA-A wikiPageWikiLink History_and_naming_of_human_leukocyte_antigens.
- HLA-A wikiPageWikiLink Human_leukocyte_antigen.
- HLA-A wikiPageWikiLink Locus_(genetics).
- HLA-A wikiPageWikiLink MHC_class_I.
- HLA-A wikiPageWikiLink Major_histocompatibility_complex.
- HLA-A wikiPageWikiLink Myasthenia_gravis.
- HLA-A wikiPageWikiLink N-terminus.
- HLA-A wikiPageWikiLink Natural_killer_cell.
- HLA-A wikiPageWikiLink Nef.
- HLA-A wikiPageWikiLink Nef_(protein).
- HLA-A wikiPageWikiLink Null_allele.
- HLA-A wikiPageWikiLink Protein.
- HLA-A wikiPageWikiLink Protein_dimer.
- HLA-A wikiPageWikiLink Proteolysis.
- HLA-A wikiPageWikiLink Signal_peptide.
- HLA-A wikiPageWikiLink Tapasin.
- HLA-A wikiPageWikiLink Transmembrane_protein.
- HLA-A wikiPageWikiLink Transporter_associated_with_antigen_processing.
- HLA-A wikiPageWikiLink File:Peptide_Loading_Complex.jpg.
- HLA-A wikiPageWikiLinkText "A".
- HLA-A wikiPageWikiLinkText "HLA-A gene".
- HLA-A wikiPageWikiLinkText "HLA-A".
- HLA-A wikiPageWikiLinkText "HLA-A*02".
- HLA-A wikiPageWikiLinkText "HLA-serotype tutorial".
- HLA-A function "Peptide presentation for immune recognition".
- HLA-A gene Beta-2_microglobulin.
- HLA-A gene "HLA-A".
- HLA-A heteropolymer "MHC class I, A".
- HLA-A imageSource "Illustration of HLA-A".
- HLA-A locus "Chromosome 15q22".
- HLA-A locus "Chromosome 6p21.3".
- HLA-A polymerType "heterodimer".
- HLA-A proteinType Cell_surface_receptor.
- HLA-A requireManualInspection "yes".
- HLA-A subunit "α".
- HLA-A subunit "β2M".
- HLA-A subunitcount "2".
- HLA-A updateCitations "no".
- HLA-A updatePage "no".
- HLA-A updateProteinBox "yes".
- HLA-A updateSummary "no".
- HLA-A wikiPageUsesTemplate Template:Anchor.
- HLA-A wikiPageUsesTemplate Template:Further2.
- HLA-A wikiPageUsesTemplate Template:Heteropolypeptide.
- HLA-A wikiPageUsesTemplate Template:PBB.
- HLA-A wikiPageUsesTemplate Template:PBB_Controls.
- HLA-A wikiPageUsesTemplate Template:PDB_Gallery.
- HLA-A wikiPageUsesTemplate Template:Reflist.
- HLA-A wikiPageUsesTemplate Template:Surface_antigens.
- HLA-A subject Category:Genes_on_human_chromosome_6.
- HLA-A subject Category:HLA-A_alleles.
- HLA-A hypernym Group.
- HLA-A type Band.
- HLA-A type Biomolecule.
- HLA-A type Protein.
- HLA-A type Thing.
- HLA-A type Q206229.
- HLA-A type Q8054.