Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/HL60> ?p ?o }
Showing triples 1 to 42 of
42
with 100 triples per page.
- HL60 abstract "The HL-60 (Human promyelocytic leukemia cells) cell line has been used for laboratory research on how certain kinds of blood cells are formed. HL-60 proliferates continuously in suspension culture in nutrient and antibiotic chemicals. The doubling time is about 36–48 hours. The cell line was derived from a 36-year-old woman with acute promyelocytic leukemia at the National Cancer Institute. HL-60 cells are predominantly a neutrophilic promyelocyte (precursor).Proliferation of HL-60 cells occurs through the transferrin and insulin receptors, which are expressed on cell surface. The requirement for insulin and transferrin is absolute, as HL-60 proliferation immediately ceases if either of these compounds is removed from the serum-free culture media. With this line, spontaneous differentiation to mature granulocytes can be induced by compounds such as dimethyl sulfoxide (DMSO), or retinoic acid. Other compounds like 1,25-dihydroxyvitamin D3, 12-O-tetradecanoylphorbol-13-acetate (TPA) and GM-CSF can induce HL-60 to differentiate to monocytic, macrophage-like and eosinophil phenotypes, respectively.The HL-60 cultured cell line provides a continuous source of human cells for studying the molecular events of myeloid differentiation and the effects of physiologic, pharmacologic, and virologic elements on this process. HL-60 cell model was used to study the effect of DNA topoisomerase (topo) IIα and IIβ on differentiation and apoptosis of cells and is especially useful in dielectrophoresis studies, which require an aqueous environment with suspended and round cells. Furthermore, these cells have been used in order to investigate whether intracellular calcium plays a role in caspase activation induced by reactive oxygen species.".
- HL60 wikiPageExternalLink CVCL_0002.
- HL60 wikiPageID "8543452".
- HL60 wikiPageLength "4066".
- HL60 wikiPageOutDegree "23".
- HL60 wikiPageRevisionID "708110393".
- HL60 wikiPageWikiLink 12-O-Tetradecanoylphorbol-13-acetate.
- HL60 wikiPageWikiLink Acute_promyelocytic_leukemia.
- HL60 wikiPageWikiLink Antibiotics.
- HL60 wikiPageWikiLink Apoptosis.
- HL60 wikiPageWikiLink Calcium.
- HL60 wikiPageWikiLink Caspase.
- HL60 wikiPageWikiLink Category:Cell_lines.
- HL60 wikiPageWikiLink Cell_culture.
- HL60 wikiPageWikiLink DNA_topoisomerase.
- HL60 wikiPageWikiLink Dimethyl_sulfoxide.
- HL60 wikiPageWikiLink Doubling_time.
- HL60 wikiPageWikiLink Eosinophil_granulocyte.
- HL60 wikiPageWikiLink Granulocyte.
- HL60 wikiPageWikiLink Granulocyte_macrophage_colony-stimulating_factor.
- HL60 wikiPageWikiLink Immortalised_cell_line.
- HL60 wikiPageWikiLink Insulin.
- HL60 wikiPageWikiLink Macrophage.
- HL60 wikiPageWikiLink Monocyte.
- HL60 wikiPageWikiLink National_Cancer_Institute.
- HL60 wikiPageWikiLink Neutrophil_granulocyte.
- HL60 wikiPageWikiLink Reactive_oxygen_species.
- HL60 wikiPageWikiLink Retinoic_acid.
- HL60 wikiPageWikiLink Transferrin.
- HL60 wikiPageWikiLinkText "HL60".
- HL60 wikiPageUsesTemplate Template:Commons_category.
- HL60 subject Category:Cell_lines.
- HL60 type Line.
- HL60 comment "The HL-60 (Human promyelocytic leukemia cells) cell line has been used for laboratory research on how certain kinds of blood cells are formed. HL-60 proliferates continuously in suspension culture in nutrient and antibiotic chemicals. The doubling time is about 36–48 hours. The cell line was derived from a 36-year-old woman with acute promyelocytic leukemia at the National Cancer Institute.".
- HL60 label "HL60".
- HL60 sameAs Q5630035.
- HL60 sameAs Célula_HL-60.
- HL60 sameAs HL60細胞.
- HL60 sameAs m.02778lp.
- HL60 sameAs Q5630035.
- HL60 wasDerivedFrom HL60?oldid=708110393.
- HL60 isPrimaryTopicOf HL60.