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- HIOC abstract "HIOC is a small-molecule agent which acts as a selective TrkB receptor agonist (active at at least 100 nM; prominent activation at 500 nM). It was derived from N-acetylserotonin (NAS). Relative to NAS, HIOC possesses greater potency and a longer half-life (~30 min or less for NAS in rats, while HIOC is still detectable up to 24 hours after administration to mice; ~4 hour half-life for HIOC in mouse brain tissues). It is described as producing long-lasting activation of the TrkB receptor and downstream signaling kinases associated with the receptor. HIOC is systemically-active and is able to penetrate the blood-brain-barrier. In animal studies, HIOC was found to robustly protect against glutamate-induced excitotoxicity, an action which was TrkB-dependent.A chemical synthesis of HIOC has been published recently.".
- HIOC atcPrefix "None".
- HIOC iupacName "N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide".
- HIOC pubchem "5012758".
- HIOC thumbnail HIOC.svg?width=300.
- HIOC wikiPageID "45179243".
- HIOC wikiPageLength "4738".
- HIOC wikiPageOutDegree "24".
- HIOC wikiPageRevisionID "698848418".
- HIOC wikiPageWikiLink 7,8-Dihydroxyflavone.
- HIOC wikiPageWikiLink ANA-12.
- HIOC wikiPageWikiLink Agonist.
- HIOC wikiPageWikiLink Blood–brain_barrier.
- HIOC wikiPageWikiLink Category:Carboxamides.
- HIOC wikiPageWikiLink Category:Indoles.
- HIOC wikiPageWikiLink Category:Neuroprotective_agents.
- HIOC wikiPageWikiLink Category:Piperidines.
- HIOC wikiPageWikiLink Category:TrkB_agonists.
- HIOC wikiPageWikiLink Category:Tryptamines.
- HIOC wikiPageWikiLink Chemical_synthesis.
- HIOC wikiPageWikiLink Cyclotraxin_B.
- HIOC wikiPageWikiLink Deoxygedunin.
- HIOC wikiPageWikiLink Drug.
- HIOC wikiPageWikiLink Excitotoxicity.
- HIOC wikiPageWikiLink Glutamic_acid.
- HIOC wikiPageWikiLink Half-life.
- HIOC wikiPageWikiLink LM22A-4.
- HIOC wikiPageWikiLink Model_organism.
- HIOC wikiPageWikiLink N-Acetylserotonin.
- HIOC wikiPageWikiLink Protein_kinase.
- HIOC wikiPageWikiLink Small_molecule.
- HIOC wikiPageWikiLink Systemic_administration.
- HIOC wikiPageWikiLink Tropomyosin_receptor_kinase_B.
- HIOC wikiPageWikiLinkText "HIOC".
- HIOC atcPrefix "None".
- HIOC c "16".
- HIOC chemspiderid "4192105".
- HIOC h "19".
- HIOC inchi "1".
- HIOC inchikey "ZIMKJLALTRLXJO-UHFFFAOYAW".
- HIOC iupacName "N-[2-ethyl]-2-oxo-3-piperidinecarboxamide".
- HIOC molecularWeight "301.34".
- HIOC n "3".
- HIOC o "3".
- HIOC pubchem "5012758".
- HIOC smiles "c1cc2ccCCNCC3CCCNC3=O".
- HIOC stdinchi "1".
- HIOC stdinchikey "ZIMKJLALTRLXJO-UHFFFAOYSA-N".
- HIOC wikiPageUsesTemplate Template:Drugbox.
- HIOC wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- HIOC wikiPageUsesTemplate Template:Neurotrophinergics.
- HIOC wikiPageUsesTemplate Template:Reflist.
- HIOC wikiPageUsesTemplate Template:Tryptamines.
- HIOC subject Category:Carboxamides.
- HIOC subject Category:Indoles.
- HIOC subject Category:Neuroprotective_agents.
- HIOC subject Category:Piperidines.
- HIOC subject Category:TrkB_agonists.
- HIOC subject Category:Tryptamines.
- HIOC hypernym Agent.
- HIOC type ChemicalSubstance.
- HIOC type Drug.
- HIOC type ChemicalObject.
- HIOC type Thing.
- HIOC type Q8386.
- HIOC comment "HIOC is a small-molecule agent which acts as a selective TrkB receptor agonist (active at at least 100 nM; prominent activation at 500 nM). It was derived from N-acetylserotonin (NAS). Relative to NAS, HIOC possesses greater potency and a longer half-life (~30 min or less for NAS in rats, while HIOC is still detectable up to 24 hours after administration to mice; ~4 hour half-life for HIOC in mouse brain tissues).".
- HIOC label "HIOC".
- HIOC sameAs Q19597510.
- HIOC sameAs m.012nxv5p.
- HIOC sameAs Q19597510.
- HIOC wasDerivedFrom HIOC?oldid=698848418.
- HIOC depiction HIOC.svg.
- HIOC isPrimaryTopicOf HIOC.