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- HHV_Latency_Associated_Transcript abstract "HHV Latency Associated Transcript (HHV LAT) is a length of RNA which accumulates in cells hosting long-term, or latent, Human Herpes Virus (HHV) infections. The LAT RNA is produced by genetic transcription from a certain region of the viral DNA. LAT regulates the viral genome and interferes with the normal activities of the infected host cell.Herpes virus may establish lifelong infection during which a reservoir virus population survives in host nerve cells for long periods of time. Such long-term Herpes infection requires a mode of cellular infection known as latent infection. During the latent infection, the metabolism of the host cell is disrupted. While the infected cell would ordinarily undergo an organized death or be removed by the immune system, the consequences of LAT production interfere with these normal processes.Latency is distinguished from lytic infection; in lytic infection many Herpes virus particles are produced and then burst or lyse the host cell. Lytic infection is sometimes known as \"productive\" infection. Latent cells harbor the virus for long time periods, then occasionally convert to productive infection which may lead to a recurrence of symptomatic Herpes symptoms.During latency, most of the Herpes DNA is inactive, with the exception of LAT, which accumulates within infected cells.The region of HHV DNA which encodes LAT is known as LAT-DNA. After splicing, LAT is a 2.0-kilobase transcript (or intron) produced from the 8.3-kb LAT-DNA. The DNA region containing LAT-DNA is known as the Latency Associated Transcript Region.Apoptosis is the process of normal cell death. In order to maintain a reservoir of latently infected host cells, Herpes virus interferes with apoptosis. HSV-1 LAT expression was once thought to produce interfering micro-RNA (miRNA) which suppress production of Human apoptosis-pathway proteins such as TGF-β1 and SMAD3, but these findings were retracted by the researchers in January 2008. HHV-8 LAT expression similarly produces miRNAs which suppress production of Thrombospondin-1 protein involved in apoptosis and angiogenesis. Expression of LAT also reduces the production of other proteins involved in the apoptosis mechanism, including proteins caspase-8 and caspase-9.LAT expression regulates the activity of the Herpes genome during latent infection. LAT expression results in the suppression of Herpes lytic genes. Genetic studies of the LAT-DNA have identified a portion known as a chromatin insulator which forms a boundary between activated LAT-DNA and the inactive lytic viral DNA.".
- HHV_Latency_Associated_Transcript wikiPageExternalLink nature06621.html.
- HHV_Latency_Associated_Transcript wikiPageID "4207289".
- HHV_Latency_Associated_Transcript wikiPageLength "10495".
- HHV_Latency_Associated_Transcript wikiPageOutDegree "46".
- HHV_Latency_Associated_Transcript wikiPageRevisionID "673282927".
- HHV_Latency_Associated_Transcript wikiPageWikiLink Alphaherpesvirinae.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Angiogenesis.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Antisense_RNA.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Apoptosis.
- HHV_Latency_Associated_Transcript wikiPageWikiLink CCCTC-binding_factor.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Caspase.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Category:Herpesviridae.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Category:Non-coding_RNA.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Category:Viral_genes.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Chromatin.
- HHV_Latency_Associated_Transcript wikiPageWikiLink DNA.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Euchromatin.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Genome.
- HHV_Latency_Associated_Transcript wikiPageWikiLink HHV_Infected_Cell_Polypeptide_0.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Harvard_Medical_School.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Herpes_simplex.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Herpesviridae.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Heterochromatin.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Histone.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Immune_system.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Intron.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Lytic_cycle.
- HHV_Latency_Associated_Transcript wikiPageWikiLink MicroRNA.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Mothers_against_decapentaplegic_homolog_3.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Nucleic_acid_sequence.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Programmed_cell_death.
- HHV_Latency_Associated_Transcript wikiPageWikiLink RNA.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Simian_varicella_virus.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Thrombospondin.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Transcription_(genetics).
- HHV_Latency_Associated_Transcript wikiPageWikiLink Transforming_growth_factor.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Transforming_growth_factor_beta.
- HHV_Latency_Associated_Transcript wikiPageWikiLink University_of_Florida_College_of_Medicine.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Varicellovirus.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Wistar_Institute.
- HHV_Latency_Associated_Transcript wikiPageWikiLink Zinc_finger.
- HHV_Latency_Associated_Transcript wikiPageWikiLinkText "HHV Latency Associated Transcript".
- HHV_Latency_Associated_Transcript wikiPageWikiLinkText "LAT".
- HHV_Latency_Associated_Transcript wikiPageWikiLinkText "Latency Associated Transcripts (LAT)".
- HHV_Latency_Associated_Transcript wikiPageWikiLinkText "latency-associated transcript".
- HHV_Latency_Associated_Transcript wikiPageUsesTemplate Template:Reflist.
- HHV_Latency_Associated_Transcript subject Category:Herpesviridae.
- HHV_Latency_Associated_Transcript subject Category:Non-coding_RNA.
- HHV_Latency_Associated_Transcript subject Category:Viral_genes.
- HHV_Latency_Associated_Transcript hypernym Length.
- HHV_Latency_Associated_Transcript type Album.
- HHV_Latency_Associated_Transcript comment "HHV Latency Associated Transcript (HHV LAT) is a length of RNA which accumulates in cells hosting long-term, or latent, Human Herpes Virus (HHV) infections. The LAT RNA is produced by genetic transcription from a certain region of the viral DNA. LAT regulates the viral genome and interferes with the normal activities of the infected host cell.Herpes virus may establish lifelong infection during which a reservoir virus population survives in host nerve cells for long periods of time.".
- HHV_Latency_Associated_Transcript label "HHV Latency Associated Transcript".
- HHV_Latency_Associated_Transcript sameAs Q5629602.
- HHV_Latency_Associated_Transcript sameAs m.0bp_pp.
- HHV_Latency_Associated_Transcript sameAs Q5629602.
- HHV_Latency_Associated_Transcript wasDerivedFrom HHV_Latency_Associated_Transcript?oldid=673282927.
- HHV_Latency_Associated_Transcript isPrimaryTopicOf HHV_Latency_Associated_Transcript.