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- H3F3A abstract "Histone H3.3 is a protein that in humans is encoded by the H3F3A gene.Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family.Mutation of H3F3A are also linked to certain cancers. p.Lys27Met were discovered in Diffuse Intrinsic Pontine Glioma (DIPG), where they are present 65-75% of tumors and confer a worse prognosis. p.Lys27Met alterations in HIST1H3B and HIST1H3C, which code for histone H3.1 have also been reported in ~10% of DIPG. H3F3A is also mutated in a smaller portion of pediatric and young adult high grade astrocytomas but more frequently as p.Gly34Arg/Val. Mutations in H3F3A and H3F3B are also found in chondroblastoma and giant cell tumor of bone.".
- H3F3A entrezgene "3020".
- H3F3A wikiPageID "14134472".
- H3F3A wikiPageLength "10499".
- H3F3A wikiPageOutDegree "10".
- H3F3A wikiPageRevisionID "678841189".
- H3F3A wikiPageWikiLink Astrocytoma.
- H3F3A wikiPageWikiLink Chondroblastoma.
- H3F3A wikiPageWikiLink Gene.
- H3F3A wikiPageWikiLink Giant-cell_tumor_of_bone.
- H3F3A wikiPageWikiLink Glioma.
- H3F3A wikiPageWikiLink H3.1.
- H3F3A wikiPageWikiLink H3F3B_(gene).
- H3F3A wikiPageWikiLink HIST1H3B.
- H3F3A wikiPageWikiLink HIST1H3C.
- H3F3A wikiPageWikiLink Protein.
- H3F3A wikiPageWikiLinkText "H3F3A".
- H3F3A requireManualInspection "no".
- H3F3A summaryText "Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. Mutation of H3F3A are also linked to certain cancers. p.Lys27Met were discovered in Diffuse Intrinsic Pontine Glioma , where they are present 65-75% of tumors and confer a worse prognosis. p.Lys27Met alterations in HIST1H3B and HIST1H3C, which code for histone H3.1 have also been reported in ~10% of DIPG. H3F3A is also mutated in a smaller portion of pediatric and young adult high grade astrocytomas but more frequently as p.Gly34Arg/Val. Mutations in H3F3A and H3F3B are also found in chondroblastoma and giant cell tumor of bone.".
- H3F3A updateCitations "yes".
- H3F3A updatePage "yes".
- H3F3A updateProteinBox "yes".
- H3F3A updateSummary "yes".
- H3F3A wikiPageUsesTemplate Template:Cite_journal.
- H3F3A wikiPageUsesTemplate Template:PBB.
- H3F3A wikiPageUsesTemplate Template:PBB_Controls.
- H3F3A wikiPageUsesTemplate Template:PBB_Further_reading.
- H3F3A wikiPageUsesTemplate Template:PBB_Summary.
- H3F3A wikiPageUsesTemplate Template:PDB_Gallery.
- H3F3A wikiPageUsesTemplate Template:Protein-stub.
- H3F3A wikiPageUsesTemplate Template:Refbegin.
- H3F3A wikiPageUsesTemplate Template:Refend.
- H3F3A wikiPageUsesTemplate Template:Reflist.
- H3F3A hypernym Protein.
- H3F3A type Biomolecule.
- H3F3A type Protein.
- H3F3A type Thing.
- H3F3A type Q206229.
- H3F3A type Q8054.
- H3F3A comment "Histone H3.3 is a protein that in humans is encoded by the H3F3A gene.Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes.".
- H3F3A label "H3F3A".
- H3F3A sameAs Q18026762.
- H3F3A sameAs m.03cvn8q.
- H3F3A sameAs Q18026762.
- H3F3A wasDerivedFrom H3F3A?oldid=678841189.
- H3F3A isPrimaryTopicOf H3F3A.