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- Glycine_transporter_2 abstract "Glycine transporter 2 (GlyT2) also known as the sodium- and chloride-dependent glycine transporter 2 or solute carrier family 6 member 5 is a protein that in humans is encoded by the SLC6A5 gene.The glycine transporter 2 is a membrane protein which recaptures glycine, a major inhibitory transmitter in the spinal cord and brainstem. GlyT2 is a specific marker of glycinergic neurons and a member of the Na+ and Cl−-coupled transporter family SLC6. Glycine uptake mediated by GlyT2 is electrogenic, coupled to three Na+ and one Cl− (i.e. two positive charges per glycine). In humans, GlyT2 is encoded by the SLC6A5 gene. Inactivation of GlyT2 in knockout mice is lethal during the second post-natal week as the absence of GlyT2 disrupts inhibitory transmission by reducing glycine release. Mutations in SLC6A5 gene are responsible for a presynaptic form of hyperekplexia, a genetic disease causing increased startle reflex. GlyT2 main physiological role is to recapture glycine released in the synaptic cleft and to maintain high glycine concentration in the presynaptic neuron. Therefore chronic inhibition of GlyT2 will deplete intracellular storage of glycine and limit its accumulation in synaptic vesicles.".
- Glycine_transporter_2 entrezgene "9152".
- Glycine_transporter_2 wikiPageID "14879059".
- Glycine_transporter_2 wikiPageLength "6105".
- Glycine_transporter_2 wikiPageOutDegree "12".
- Glycine_transporter_2 wikiPageRevisionID "678834825".
- Glycine_transporter_2 wikiPageWikiLink Brainstem.
- Glycine_transporter_2 wikiPageWikiLink Category:Solute_carrier_family.
- Glycine_transporter_2 wikiPageWikiLink Gene.
- Glycine_transporter_2 wikiPageWikiLink Glycine.
- Glycine_transporter_2 wikiPageWikiLink Hyperekplexia.
- Glycine_transporter_2 wikiPageWikiLink Knockout.
- Glycine_transporter_2 wikiPageWikiLink Protein.
- Glycine_transporter_2 wikiPageWikiLink Sodium:neurotransmitter_symporter.
- Glycine_transporter_2 wikiPageWikiLink Solute_carrier_family.
- Glycine_transporter_2 wikiPageWikiLink Spinal_cord.
- Glycine_transporter_2 wikiPageWikiLink Startle_response.
- Glycine_transporter_2 wikiPageWikiLinkText "GlyT2".
- Glycine_transporter_2 wikiPageWikiLinkText "Glycine transporter 2".
- Glycine_transporter_2 wikiPageWikiLinkText "glycine transporter 2".
- Glycine_transporter_2 requireManualInspection "no".
- Glycine_transporter_2 updateCitations "yes".
- Glycine_transporter_2 updatePage "yes".
- Glycine_transporter_2 updateProteinBox "yes".
- Glycine_transporter_2 updateSummary "no".
- Glycine_transporter_2 wikiPageUsesTemplate Template:Cite_journal.
- Glycine_transporter_2 wikiPageUsesTemplate Template:Glycinergics.
- Glycine_transporter_2 wikiPageUsesTemplate Template:Membrane-protein-stub.
- Glycine_transporter_2 wikiPageUsesTemplate Template:Membrane_transport_proteins.
- Glycine_transporter_2 wikiPageUsesTemplate Template:PBB.
- Glycine_transporter_2 wikiPageUsesTemplate Template:PBB_Controls.
- Glycine_transporter_2 wikiPageUsesTemplate Template:PBB_Further_reading.
- Glycine_transporter_2 wikiPageUsesTemplate Template:Refbegin.
- Glycine_transporter_2 wikiPageUsesTemplate Template:Refend.
- Glycine_transporter_2 wikiPageUsesTemplate Template:Reflist.
- Glycine_transporter_2 subject Category:Solute_carrier_family.
- Glycine_transporter_2 hypernym Protein.
- Glycine_transporter_2 type Biomolecule.
- Glycine_transporter_2 type Protein.
- Glycine_transporter_2 type Thing.
- Glycine_transporter_2 type Q206229.
- Glycine_transporter_2 type Q8054.
- Glycine_transporter_2 comment "Glycine transporter 2 (GlyT2) also known as the sodium- and chloride-dependent glycine transporter 2 or solute carrier family 6 member 5 is a protein that in humans is encoded by the SLC6A5 gene.The glycine transporter 2 is a membrane protein which recaptures glycine, a major inhibitory transmitter in the spinal cord and brainstem. GlyT2 is a specific marker of glycinergic neurons and a member of the Na+ and Cl−-coupled transporter family SLC6.".
- Glycine_transporter_2 label "Glycine transporter 2".
- Glycine_transporter_2 sameAs Q18033875.
- Glycine_transporter_2 sameAs m.03h020w.
- Glycine_transporter_2 sameAs Q18033875.
- Glycine_transporter_2 wasDerivedFrom Glycine_transporter_2?oldid=678834825.
- Glycine_transporter_2 isPrimaryTopicOf Glycine_transporter_2.