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- Gla_domain abstract "Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain is a protein domain that contains post-translational modifications of many glutamate residues by vitamin K-dependent carboxylation to form γ-carboxyglutamate (Gla). Proteins with this domain are known informally as Gla proteins. The Gla residues are responsible for the high-affinity binding of calcium ions.The GLA domain binds calcium ions by chelating them between two carboxylic acid residues. These residues are part of a region that starts at the N-terminal extremity of the mature form of Gla proteins, and that ends with a conserved aromatic residue. This results in a conserved Gla-x(3)-Gla-x-Cys motif that is found in the middle of the domain, and which seems to be important for substrate recognition by the carboxylase.The 3D structures of several Gla domains have been solved. Calcium ions induce conformational changes in the Gla domain and are necessary for the Gla domain to fold properly. A common structural feature of functional Gla domains is the clustering of N-terminal hydrophobic residues into a hydrophobic patch that mediates interaction with the cell surface membrane.At present, the following human Gla-containing proteins (Gla proteins) have been characterized to the level of primary structure: the blood coagulation factors II (prothrombin), VII, IX, and X, the anticoagulant proteins C and S, and the factor X-targeting protein Z. The bone Gla protein osteocalcin, the calcification-inhibiting matrix Gla protein (MGP), the cell growth regulating \"growth arrest specific gene 6\" protein GAS6, periostin (a factor necessary for migration and adhesion of epithelial cells), two transmembrane Gla proteins (TMGPs), and two proline-rich Gla-proteins (PRGPs), the function of which at present are unknown.In all cases in which their function was known, the presence of the Gla residues in these proteins turned out to be essential for functional activity.".
- Gla_domain symbol "Gla".
- Gla_domain thumbnail 1dan_opm.png?width=300.
- Gla_domain wikiPageID "14091970".
- Gla_domain wikiPageLength "6625".
- Gla_domain wikiPageOutDegree "48".
- Gla_domain wikiPageRevisionID "635074019".
- Gla_domain wikiPageWikiLink Anticoagulant.
- Gla_domain wikiPageWikiLink Calcification.
- Gla_domain wikiPageWikiLink Carboxyglutamic_acid.
- Gla_domain wikiPageWikiLink Carboxylation.
- Gla_domain wikiPageWikiLink Carboxylic_acid.
- Gla_domain wikiPageWikiLink Category:Peripheral_membrane_proteins.
- Gla_domain wikiPageWikiLink Category:Protein_domains.
- Gla_domain wikiPageWikiLink Cell_death.
- Gla_domain wikiPageWikiLink Cell_growth.
- Gla_domain wikiPageWikiLink Coagulation.
- Gla_domain wikiPageWikiLink Embryogenesis.
- Gla_domain wikiPageWikiLink Epithelium.
- Gla_domain wikiPageWikiLink Factor_IX.
- Gla_domain wikiPageWikiLink Factor_VII.
- Gla_domain wikiPageWikiLink Factor_X.
- Gla_domain wikiPageWikiLink GAS6.
- Gla_domain wikiPageWikiLink ITIH2.
- Gla_domain wikiPageWikiLink Immune_system.
- Gla_domain wikiPageWikiLink Inflammation.
- Gla_domain wikiPageWikiLink Inter-alpha-trypsin_inhibitor.
- Gla_domain wikiPageWikiLink Matrix_gla_protein.
- Gla_domain wikiPageWikiLink Mineralization_(biology).
- Gla_domain wikiPageWikiLink Osteocalcin.
- Gla_domain wikiPageWikiLink PRRG1.
- Gla_domain wikiPageWikiLink PRRG2.
- Gla_domain wikiPageWikiLink PRRG3.
- Gla_domain wikiPageWikiLink PRRG4.
- Gla_domain wikiPageWikiLink Periostin.
- Gla_domain wikiPageWikiLink Protein_C.
- Gla_domain wikiPageWikiLink Protein_S.
- Gla_domain wikiPageWikiLink Protein_Z.
- Gla_domain wikiPageWikiLink Protein_domain.
- Gla_domain wikiPageWikiLink Thrombin.
- Gla_domain wikiPageWikiLink Transthyretin.
- Gla_domain wikiPageWikiLink Vascular_permeability.
- Gla_domain wikiPageWikiLink Vitamin_K.
- Gla_domain wikiPageWikiLinkText "GLA domain".
- Gla_domain wikiPageWikiLinkText "GLA domains".
- Gla_domain wikiPageWikiLinkText "Gla domain".
- Gla_domain wikiPageWikiLinkText "Gla module".
- Gla_domain wikiPageWikiLinkText "Gla proteins".
- Gla_domain wikiPageWikiLinkText "Gla".
- Gla_domain wikiPageWikiLinkText "Gla-proteins".
- Gla_domain wikiPageWikiLinkText "gamma-carboxyglutamic acid (Gla) domain".
- Gla_domain wikiPageWikiLinkText "gla domain".
- Gla_domain caption "Anchoring of Coagulation factor VIIa to the membrane through its GLA domain".
- Gla_domain interpro "IPR000294".
- Gla_domain name "GLA Domain".
- Gla_domain opmFamily "97".
- Gla_domain opmProtein "1".
- Gla_domain pdb "A:6-47 A:57-98 B:53-93 A:49-90 :49-90 A:49-90 :79-90 L:45-86 L:45-86 :45-86 :45-86 G:45-84 C:6-46 C:6-46 L:8-48 :52-93 :52-93 :52-93 G:52-91 C:47-75 L:65-106 L:65-106 L:65-106 L:65-106 L:65-106 L:65-106 L:65-106 L:65-106 L:65-106".
- Gla_domain pfam "PF00594".
- Gla_domain prosite "PDOC00011".
- Gla_domain scop "1".
- Gla_domain symbol "Gla".
- Gla_domain width "220".
- Gla_domain wikiPageUsesTemplate Template:InterPro.
- Gla_domain wikiPageUsesTemplate Template:Membrane-protein-stub.
- Gla_domain wikiPageUsesTemplate Template:PDB3.
- Gla_domain wikiPageUsesTemplate Template:Pfam_box.
- Gla_domain wikiPageUsesTemplate Template:Reflist.
- Gla_domain subject Category:Peripheral_membrane_proteins.
- Gla_domain subject Category:Protein_domains.
- Gla_domain hypernym Domain.
- Gla_domain type Biomolecule.
- Gla_domain type Protein.
- Gla_domain type Chemical.
- Gla_domain type Domain.
- Gla_domain type Redirect.
- Gla_domain type Thing.
- Gla_domain type Q206229.
- Gla_domain type Q8054.
- Gla_domain comment "Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain is a protein domain that contains post-translational modifications of many glutamate residues by vitamin K-dependent carboxylation to form γ-carboxyglutamate (Gla). Proteins with this domain are known informally as Gla proteins. The Gla residues are responsible for the high-affinity binding of calcium ions.The GLA domain binds calcium ions by chelating them between two carboxylic acid residues.".
- Gla_domain label "Gla domain".
- Gla_domain sameAs Q5566066.
- Gla_domain sameAs m.03gqjdc.
- Gla_domain sameAs Q5566066.
- Gla_domain wasDerivedFrom Gla_domain?oldid=635074019.
- Gla_domain depiction 1dan_opm.png.
- Gla_domain isPrimaryTopicOf Gla_domain.