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- Giant_depolarizing_potentials abstract "A giant depolarizing potential (GDP) is a type of patterned spontaneous activity that can be observed in preparations of developing brain at early stages of development. These patterns of activity differ a lot from both the adult brain activity, and epileptiform activity. In humans they exist only on prenatal stages, in rats they last for approximately P6.GDPs were postulated to be essential for the establishment and maturation of synaptic connections in the immature brain.One of the main conditions for GDP development (that is met in premature but not adult brain) is that GABA action on these stages should be excitatory rather than inhibitory. This is caused by a much higher concentration of Cl− concentration in the cytoplasm of neonatal neurons. Further, the expression of the chloride transporter, KCC2, is less in immature neurons, as a result of which there is the above-mentioned high intracellular chloride. On receiving a GABAergic stimulus, there is an efflux of Chloride from the cell, resulting in depolarization of the cell. This causes the GDPs. Once the KCC2 expression is relatively high, as in the adult, mature neurons, the GDPs almost simultaneously disappear. The increased level of KCC2 expression in adult, mature neurons alone is not the reason for the disappearance of the GDPs, however.".
- Giant_depolarizing_potentials wikiPageID "379962".
- Giant_depolarizing_potentials wikiPageLength "1917".
- Giant_depolarizing_potentials wikiPageOutDegree "13".
- Giant_depolarizing_potentials wikiPageRevisionID "642021563".
- Giant_depolarizing_potentials wikiPageWikiLink Brain.
- Giant_depolarizing_potentials wikiPageWikiLink Category:Neurology.
- Giant_depolarizing_potentials wikiPageWikiLink Chloride.
- Giant_depolarizing_potentials wikiPageWikiLink Cytoplasm.
- Giant_depolarizing_potentials wikiPageWikiLink Epilepsy.
- Giant_depolarizing_potentials wikiPageWikiLink Excitatory_postsynaptic_potential.
- Giant_depolarizing_potentials wikiPageWikiLink Gamma-Aminobutyric_acid.
- Giant_depolarizing_potentials wikiPageWikiLink Human.
- Giant_depolarizing_potentials wikiPageWikiLink Inhibitory_postsynaptic_potential.
- Giant_depolarizing_potentials wikiPageWikiLink Postpartum_period.
- Giant_depolarizing_potentials wikiPageWikiLink Prenatal_development.
- Giant_depolarizing_potentials wikiPageWikiLink Rat.
- Giant_depolarizing_potentials wikiPageWikiLink Synapse.
- Giant_depolarizing_potentials wikiPageWikiLinkText "Giant depolarizing potentials".
- Giant_depolarizing_potentials att "June 2014".
- Giant_depolarizing_potentials date "December 2007".
- Giant_depolarizing_potentials wikiPageUsesTemplate Template:Citation_needed.
- Giant_depolarizing_potentials wikiPageUsesTemplate Template:Orphan.
- Giant_depolarizing_potentials wikiPageUsesTemplate Template:Reflist.
- Giant_depolarizing_potentials subject Category:Neurology.
- Giant_depolarizing_potentials hypernym Activity.
- Giant_depolarizing_potentials type Sport.
- Giant_depolarizing_potentials type Specialty.
- Giant_depolarizing_potentials comment "A giant depolarizing potential (GDP) is a type of patterned spontaneous activity that can be observed in preparations of developing brain at early stages of development. These patterns of activity differ a lot from both the adult brain activity, and epileptiform activity.".
- Giant_depolarizing_potentials label "Giant depolarizing potentials".
- Giant_depolarizing_potentials sameAs Q17120628.
- Giant_depolarizing_potentials sameAs m.021gcc.
- Giant_depolarizing_potentials sameAs Q17120628.
- Giant_depolarizing_potentials wasDerivedFrom Giant_depolarizing_potentials?oldid=642021563.
- Giant_depolarizing_potentials isPrimaryTopicOf Giant_depolarizing_potentials.