Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Genetic_resistance_to_malaria> ?p ?o }
- Genetic_resistance_to_malaria abstract "Genetic resistance to disease, of which malaria is a specific example, is an inherited change in the genome of an organism that confers a selective survival advantage due to conferring or increasing resistance to disease. In the case of malaria, an infection of the erythrocytes (red blood cells), the genetic change is an alteration of the hemoglobin molecule or cellular proteins or enzymes of erythrocytes that inhibits invasion by or replication of Plasmodia, the microorganisms that cause the disease. This article focuses on mechanisms of human innate resistance to malaria.Malaria has placed the strongest known selective pressure on the human genome since the origination of agriculture within the past 10,000 years. Plasmodium falciparum was probably not able to gain a foothold among African populations until larger sedentary communities emerged in association with the evolution of domestic agriculture in Africa (the agricultural revolution). Several inherited variants in erythrocytes have become common in formerly malarious parts of the world as a result of selection exerted by this parasite. This selection was historically important as the first documented example of disease as an agent of natural selection in humans. It was also the first example of genetically controlled innate immunity that operates early in the course of infections, preceding adaptive immunity which exerts effects after several days. In malaria, as in other diseases, innate immunity leads into, and stimulates, adaptive immunity.One of the key reasons for the high fatality rate in P. falciparum malaria is the occurrence of so-called cerebral malaria. Patients become confused, disoriented and often lapse into a terminal coma. Clumps of malaria-infested red cells adhere to the endothelium and occlude the microcirculation of the brain with deadly consequences. The P. falciparum parasite alters the characteristics of the red cell membrane, making them more \"sticky\". Clusters of parasitized red cells exceed the size of the capillary circulation blocking blood flow and producing cerebral hypoxia. Cerebral malaria accounts for 80% of malaria deaths. Thalassemic erythrocytes adhere to parasitized red cells much less readily than do their normal counterparts. This alteration would lessen the chance of developing cerebral malaria.P. vivax is clearly a less potent agent of natural selection that is P. falciparum. However, the morbidity of P. vivax is not negligible. For example, P. vivax infections induce a greater inflammatory response in the lungs than is observed in P. falciparum infections, and progressive alveolar capillary dysfunction is observed after the treatment of vivax malaria. Epidemiological studies in the Amazonian region of Brazil have shown that the number and rate of hospital admissions for P. vivax infections have recently increased while those of P. falciparum have decreased.These inherited changes to hemoglobin or other characteristic erythrocyte proteins which are critical and rather invariant features of mammalian biochemistry, usually result in some kind of anemia, a disease or defect of red blood cells. These changes are referred to by the names of the diseases resulting from them including sickle cell disease, thalassemia, glucose-6-phosphate dehydrogenase (G6PD) deficiency, and others. These blood disorders cause increased morbidity and mortality in areas of the world where malaria is no longer prevalent.".
- Genetic_resistance_to_malaria wikiPageExternalLink malaria_sickle.html.
- Genetic_resistance_to_malaria wikiPageExternalLink hemoglobinopathy.html.
- Genetic_resistance_to_malaria wikiPageExternalLink G6PDDeficiency.aspx.
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- Genetic_resistance_to_malaria wikiPageRevisionID "704369720".
- Genetic_resistance_to_malaria wikiPageWikiLink Actin.
- Genetic_resistance_to_malaria wikiPageWikiLink Adaptive_immune_system.
- Genetic_resistance_to_malaria wikiPageWikiLink African_Americans.
- Genetic_resistance_to_malaria wikiPageWikiLink Agricultural_revolution.
- Genetic_resistance_to_malaria wikiPageWikiLink Agriculture.
- Genetic_resistance_to_malaria wikiPageWikiLink Allele.
- Genetic_resistance_to_malaria wikiPageWikiLink Allele_frequency.
- Genetic_resistance_to_malaria wikiPageWikiLink Amazon_River.
- Genetic_resistance_to_malaria wikiPageWikiLink Amba_people.
- Genetic_resistance_to_malaria wikiPageWikiLink Anemia.
- Genetic_resistance_to_malaria wikiPageWikiLink Angola.
- Genetic_resistance_to_malaria wikiPageWikiLink Ankyrin.
- Genetic_resistance_to_malaria wikiPageWikiLink Antigen.
- Genetic_resistance_to_malaria wikiPageWikiLink Antimalarial_medication.
- Genetic_resistance_to_malaria wikiPageWikiLink Association_mapping.
- Genetic_resistance_to_malaria wikiPageWikiLink Band_3.
- Genetic_resistance_to_malaria wikiPageWikiLink Brazil.
- Genetic_resistance_to_malaria wikiPageWikiLink Carbon_monoxide.
- Genetic_resistance_to_malaria wikiPageWikiLink Category:Cell_biology.
- Genetic_resistance_to_malaria wikiPageWikiLink Category:Evolutionary_biology.
- Genetic_resistance_to_malaria wikiPageWikiLink Category:Malaria.
- Genetic_resistance_to_malaria wikiPageWikiLink Category:Population_genetics.
- Genetic_resistance_to_malaria wikiPageWikiLink Cell_membrane.
- Genetic_resistance_to_malaria wikiPageWikiLink Cell_nucleus.
- Genetic_resistance_to_malaria wikiPageWikiLink Central_Africa.
- Genetic_resistance_to_malaria wikiPageWikiLink Disease.
- Genetic_resistance_to_malaria wikiPageWikiLink Drosophila.
- Genetic_resistance_to_malaria wikiPageWikiLink Duffy_binding_proteins.
- Genetic_resistance_to_malaria wikiPageWikiLink EPB41.
- Genetic_resistance_to_malaria wikiPageWikiLink Eastern_Highlands.
- Genetic_resistance_to_malaria wikiPageWikiLink Endogamy.
- Genetic_resistance_to_malaria wikiPageWikiLink Endothelium.
- Genetic_resistance_to_malaria wikiPageWikiLink Enzyme.
- Genetic_resistance_to_malaria wikiPageWikiLink Equatorial_Guinea.
- Genetic_resistance_to_malaria wikiPageWikiLink Ethiopia.
- Genetic_resistance_to_malaria wikiPageWikiLink Evolutionary_pressure.
- Genetic_resistance_to_malaria wikiPageWikiLink Fitness_(biology).
- Genetic_resistance_to_malaria wikiPageWikiLink GYPA.
- Genetic_resistance_to_malaria wikiPageWikiLink GYPB.
- Genetic_resistance_to_malaria wikiPageWikiLink Genome-wide_association_study.
- Genetic_resistance_to_malaria wikiPageWikiLink Genotype.
- Genetic_resistance_to_malaria wikiPageWikiLink Glucose.
- Genetic_resistance_to_malaria wikiPageWikiLink Glucose-6-phosphate_dehydrogenase.
- Genetic_resistance_to_malaria wikiPageWikiLink Glucose-6-phosphate_dehydrogenase_deficiency.
- Genetic_resistance_to_malaria wikiPageWikiLink Glycolysis.
- Genetic_resistance_to_malaria wikiPageWikiLink Glycophorin_C.
- Genetic_resistance_to_malaria wikiPageWikiLink Greece.
- Genetic_resistance_to_malaria wikiPageWikiLink Haematopoiesis.
- Genetic_resistance_to_malaria wikiPageWikiLink Hardy–Weinberg_principle.
- Genetic_resistance_to_malaria wikiPageWikiLink Heme_oxygenase.
- Genetic_resistance_to_malaria wikiPageWikiLink Hemoglobin.
- Genetic_resistance_to_malaria wikiPageWikiLink Hemoglobin_C.
- Genetic_resistance_to_malaria wikiPageWikiLink Hemoglobin_E.
- Genetic_resistance_to_malaria wikiPageWikiLink Hereditary_elliptocytosis.
- Genetic_resistance_to_malaria wikiPageWikiLink Himalayas.
- Genetic_resistance_to_malaria wikiPageWikiLink Human.
- Genetic_resistance_to_malaria wikiPageWikiLink Human_genome.
- Genetic_resistance_to_malaria wikiPageWikiLink India.
- Genetic_resistance_to_malaria wikiPageWikiLink Indo-Gangetic_Plain.
- Genetic_resistance_to_malaria wikiPageWikiLink Inflammation.
- Genetic_resistance_to_malaria wikiPageWikiLink Innate_immune_system.
- Genetic_resistance_to_malaria wikiPageWikiLink Inner_Terai_Valleys_of_Nepal.
- Genetic_resistance_to_malaria wikiPageWikiLink J._B._S._Haldane.
- Genetic_resistance_to_malaria wikiPageWikiLink Kenya.
- Genetic_resistance_to_malaria wikiPageWikiLink Lake_Victoria.
- Genetic_resistance_to_malaria wikiPageWikiLink Linkage_disequilibrium.
- Genetic_resistance_to_malaria wikiPageWikiLink Lung.
- Genetic_resistance_to_malaria wikiPageWikiLink Madagascar.
- Genetic_resistance_to_malaria wikiPageWikiLink Major_histocompatibility_complex.
- Genetic_resistance_to_malaria wikiPageWikiLink Malagasy_people.
- Genetic_resistance_to_malaria wikiPageWikiLink Malaria_vaccine.
- Genetic_resistance_to_malaria wikiPageWikiLink Malaysia.
- Genetic_resistance_to_malaria wikiPageWikiLink Mammal.
- Genetic_resistance_to_malaria wikiPageWikiLink Mediterranean_Sea.
- Genetic_resistance_to_malaria wikiPageWikiLink Mutation_rate.
- Genetic_resistance_to_malaria wikiPageWikiLink Natural_selection.
- Genetic_resistance_to_malaria wikiPageWikiLink Nepal.
- Genetic_resistance_to_malaria wikiPageWikiLink Oxygen.
- Genetic_resistance_to_malaria wikiPageWikiLink Papua_New_Guinea.
- Genetic_resistance_to_malaria wikiPageWikiLink Parasitism.
- Genetic_resistance_to_malaria wikiPageWikiLink Pattern_recognition_receptor.
- Genetic_resistance_to_malaria wikiPageWikiLink Pentose_phosphate_pathway.
- Genetic_resistance_to_malaria wikiPageWikiLink Phosphatidylserine.
- Genetic_resistance_to_malaria wikiPageWikiLink Plasmodium.
- Genetic_resistance_to_malaria wikiPageWikiLink Plasmodium_falciparum.
- Genetic_resistance_to_malaria wikiPageWikiLink Primaquine.
- Genetic_resistance_to_malaria wikiPageWikiLink Pyruvate_kinase_deficiency.
- Genetic_resistance_to_malaria wikiPageWikiLink RNA.
- Genetic_resistance_to_malaria wikiPageWikiLink Radical_(chemistry).
- Genetic_resistance_to_malaria wikiPageWikiLink Red_blood_cell.
- Genetic_resistance_to_malaria wikiPageWikiLink Roman_Empire.
- Genetic_resistance_to_malaria wikiPageWikiLink Sedentism.