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- GenSpera abstract "GenSpera, Inc. (OTC:QB GNSZ) is a development-stage pharmaceutical company based in San Antonio, Texas. The company is focused on therapeutics that deliver a cancer-destroying drug directly to the tumor or its supporting environment, the tumor vasculature.The company's prodrug technology renders the drug inactive until it encounters the programmed target, thereby delivering the cytotoxin directly to the cancer or the vessels that support it, while potentially avoiding the side effects associated with current chemotherapies. A prodrug is an inactive precursor of a drug that is converted into its active form at a targeted site.GenSpera's lead drug candidate, G-202, is currently in a Phase II clinical trial for patients with hepatocellular carcinoma (HCC) whose disease has failed to improve on standard therapy for this indication. G-202 is also being evaluated in a Phase II clinical trial in glioblastoma patients with recurrent disease after surgery and/or radiation treatment of the primary tumor. G-202 targets the enzyme PSMA, found on the walls of blood vessels that feed most cancerous tumors, destroying the tumor blood supply. In contrast with anti-angiogenic agents, G-202 destroys existing as well as new cancer blood vessels. G-202 received Orphan Drug Designation from U.S. Food and Drug Administration for the treatment of HCC, the most common form of primary liver cancer.The company also holds patents on prodrug candidates that target the prostate-specific enzymes Prostate Specific Antigen (PSA) and Human Glandular Kallikrein (hK2). These candidates are expected to be useful in the treatment of prostate cancer.The active ingredient in G-202 is a chemotherapeutic agent derived from thapsigargin, a plant-based cytotoxin that kills by disrupting the calcium balance in cancer cells. GenSpera's prodrug delivery system keeps the thapsigargin inactive in the body until it finds cells that it has been programmed to seek. Once those cells in the body are found, the prodrug releases its active ingredient and destroys all of the targeted cells.The National Cancer Institute had previously demonstrated that thaspigargin was ten-to-a-hundredfold more potent than traditional chemotherapeutic agents in killing all types of cells. Thapsigargin kills cells irrespective of the rate of cell division, which may provide an effective approach to kill both fast- and slow-growing cancers as well as cancer stem cells.".
- GenSpera foundingYear "2003".
- GenSpera industry Pharmaceutical_industry.
- GenSpera keyPerson Chairman.
- GenSpera keyPerson Chief_executive_officer.
- GenSpera keyPerson Chief_financial_officer.
- GenSpera keyPerson Chief_operating_officer.
- GenSpera keyPerson President_(corporate_title).
- GenSpera locationCity San_Antonio.
- GenSpera locationCity Texas.
- GenSpera numberOfEmployees "2".
- GenSpera type Public_company.
- GenSpera wikiPageExternalLink genspera.com.
- GenSpera wikiPageExternalLink www.genspera.com.
- GenSpera wikiPageID "31257653".
- GenSpera wikiPageLength "7879".
- GenSpera wikiPageOutDegree "34".
- GenSpera wikiPageRevisionID "609479478".
- GenSpera wikiPageWikiLink Angiogenesis.
- GenSpera wikiPageWikiLink Category:Biotechnology_companies_of_the_United_States.
- GenSpera wikiPageWikiLink Category:Companies_based_in_San_Antonio,_Texas.
- GenSpera wikiPageWikiLink Category:Companies_established_in_2003.
- GenSpera wikiPageWikiLink Cephalon.
- GenSpera wikiPageWikiLink Chairman.
- GenSpera wikiPageWikiLink Chief_executive_officer.
- GenSpera wikiPageWikiLink Chief_financial_officer.
- GenSpera wikiPageWikiLink Chief_operating_officer.
- GenSpera wikiPageWikiLink Cytotoxicity.
- GenSpera wikiPageWikiLink Glutamate_carboxypeptidase_II.
- GenSpera wikiPageWikiLink Intracellular.
- GenSpera wikiPageWikiLink Johns_Hopkins_School_of_Medicine.
- GenSpera wikiPageWikiLink Kallikrein.
- GenSpera wikiPageWikiLink Mediterranean_Basin.
- GenSpera wikiPageWikiLink Memorial_Sloan_Kettering_Cancer_Center.
- GenSpera wikiPageWikiLink National_Cancer_Institute.
- GenSpera wikiPageWikiLink Natural_product.
- GenSpera wikiPageWikiLink Neuroscience.
- GenSpera wikiPageWikiLink OTC_Markets_Group.
- GenSpera wikiPageWikiLink Orphan_drug.
- GenSpera wikiPageWikiLink Peptide.
- GenSpera wikiPageWikiLink Pharmaceutical_industry.
- GenSpera wikiPageWikiLink President_(corporate_title).
- GenSpera wikiPageWikiLink Private_placement.
- GenSpera wikiPageWikiLink Prodrug.
- GenSpera wikiPageWikiLink Prostate-specific_antigen.
- GenSpera wikiPageWikiLink Public_company.
- GenSpera wikiPageWikiLink San_Antonio.
- GenSpera wikiPageWikiLink Texas.
- GenSpera wikiPageWikiLink Thapsigargin.
- GenSpera wikiPageWikiLink University_of_Copenhagen.
- GenSpera foundation "2003".
- GenSpera founder "*Craig Dionne, PhD *John Isaacs, PhD *Samuel Denmeade, MD".
- GenSpera industry Pharmaceutical_industry.
- GenSpera keyPeople "*Craig Dionne, PhD *Russell Richerson, PhD".
- GenSpera locationCity San_Antonio.
- GenSpera locationCity Texas.
- GenSpera locationCountry "USA".
- GenSpera logo "GenSpera Logo for Wikipedia.jpg".
- GenSpera logoSize "220".
- GenSpera name "GenSpera, Inc.".
- GenSpera numEmployees "2".
- GenSpera products "G-202".
- GenSpera tradedAs "OTC:QB GNSZ".
- GenSpera type Public_company.
- GenSpera wikiPageUsesTemplate Template:Infobox_company.
- GenSpera wikiPageUsesTemplate Template:Orphan.
- GenSpera wikiPageUsesTemplate Template:Reflist.
- GenSpera wikiPageUsesTemplate Template:URL.
- GenSpera subject Category:Biotechnology_companies_of_the_United_States.
- GenSpera subject Category:Companies_based_in_San_Antonio,_Texas.
- GenSpera subject Category:Companies_established_in_2003.
- GenSpera type Agent.
- GenSpera type Company.
- GenSpera type Organisation.
- GenSpera type Company.
- GenSpera type Establishment.
- GenSpera type Organization.
- GenSpera type Organization.
- GenSpera type Organization.
- GenSpera type Agent.
- GenSpera type SocialPerson.
- GenSpera type Thing.
- GenSpera type Q43229.
- GenSpera comment "GenSpera, Inc. (OTC:QB GNSZ) is a development-stage pharmaceutical company based in San Antonio, Texas.".
- GenSpera label "GenSpera".
- GenSpera sameAs Q5530845.
- GenSpera sameAs m.0gjdj_s.
- GenSpera sameAs Q5530845.
- GenSpera wasDerivedFrom GenSpera?oldid=609479478.
- GenSpera homepage genspera.com.
- GenSpera homepage www.genspera.com.
- GenSpera isPrimaryTopicOf GenSpera.
- GenSpera name "GenSpera, Inc.".