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- Gastão_Rosenfeld abstract "Gastão Rosenfeld (born Budapest, July 26, 1912; died São Paulo, July 15, 1990), was a Brazilian physician and biomedical scientist, one of the co-discoverers of bradykinin, together with Maurício Rocha e Silva and Wilson Teixeira Beraldo, in 1949.Rosenfeld was born in 1912 in Budapest, Hungary, to a family of Jewish origin, and came with his parents to Brazil in 1913, graduating in medicine in 1938. Since 1932, he began to devote himself to Hematology. His work at the Butantan Institute, a research institution located in São Paulo. began in 1945, invited by Prof. William Otto Bier a famous bacteriologist (then director of the Institute), and soon was charged with organizing and heading the Laboratory of Hematology and being responsible for its research line on Experimental Hematology. In 1947 Dr. Rosenfeld started to work at São Paulo's Instituto Biológico, but returned to the Institute in 1951. and in 1954 took over as chief physician at the Hospital Vital Brazil, where he served until 1966.The hospital was founded by Dr. Vital Brazil, one of the world pioneers in the study of animal envenomation and was purposed as a unit of acute care for the victims of venomous animals. As such, Dr. Rosenfeld was concerned about the lack of medical knowledge about the actions of venoms on the human body and its medical therapy, at the time. Due to the fact that it was the only hospital in Brazil which was exclusively dedicated to these episodes, and, besides, since it was attached to a research and educational institution, Dr. Rosenfeld favored from the beginning the systematic observation of patients, resulting over the years in a large and original body of new knowledge about symptoms and treatment of victims of animal poisoning. This, in addition, spurred the realization of a large number of laboratory studies. Based on his experience in the field of hematology, Dr. Rosenfeld published many studies on the pathophysiology of snake bite poisoning in experimental animals, and was able to apply this rich knowledge to the clinical area. Rosenfeld was interested in the study of biochemistry of the action of snake venom toxins in animals and humans, particularly those of the Bothrops family (lancehead or jararaca), which is extremely abundant all over Brazil and which caused a great number of accidents and deaths at his time. Among other things, he investigated the action of the venom of this snake on fibrinolysis and blood coagulation. In 1948, as part of a research team at the Instituto Biológico, Dr. Rosenfeld co-discovered, with two other Brazilian physiologists and pharmacologists, Drs. Maurício Rocha e Silva and Wilson Teixeira Beraldo, a new endogenous peptide capable of causing a powerful fall of blood pressure on animal preparations, which they called bradykinin. The substance, a short kinin with nine aminoacids only, was detected in the blood plasma of dogs after the addition of venom extracted from the Bothrops jararaca snake, brought by Rosenfeld from the Butantan Institute. The discovery was part of a continuing study on circulatory shock and proteolytic enzymes related to the toxicology of snake bites, started by Rocha e Silva as early as 1939.Bradykinin was to prove a new autopharmacological principle, i.e., a substance that is released in the body by a metabolic modification from precursors, which are pharmacologically active. The discovery of bradykinin led to a new understanding of many physiological and pathological phenomena including circulatory shock induced by venoms and toxins. Ultimately, the extensive study of the origins of its formation in the body, by Sérgio Henrique Ferreira, a noted Brazilian pharmacologist, and others, led to the development of new anti-hypertensive agents in humans, such as captopril, developed by Squibb under the name of Capoten, and still widely used. However, the team of Brazilian scientists, including Rocha e Silva, Beraldo, Rosenfeld and Ferreira never came to enjoy the royalties of such discovery, since they always published in the public domain of pure scientific knowledge.Among his many other contributions to biomedical sciences are the development of a rapid staining for blood smears combining May–Grunwald and Giemsa techniques in 1947 (Rosenfeld staining), the introduction a new treatment for chronic leukemia using personal control of maintenance dosis (1955) and described hementerin, an anticoagulant isolated of a Brazilian species of leech (Haementeria depressa) jointly with Eva Maria Antonia Kelen in 1975.Dr. Rosenfeld was also an important scientific leader, having been involved in the foundation of the Brazilian Society for the Advancement of Science, in 1949. In addition, he was an accomplished amateur photographer. A part of his photographic collection between 1962 and 1976 has been preserved at the Instituto Moreira Salles.".
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- Gastão_Rosenfeld wikiPageWikiLink Acute_care.
- Gastão_Rosenfeld wikiPageWikiLink Amino_acid.
- Gastão_Rosenfeld wikiPageWikiLink Anticoagulant.
- Gastão_Rosenfeld wikiPageWikiLink Antihypertensive_drug.
- Gastão_Rosenfeld wikiPageWikiLink Autopharmacology.
- Gastão_Rosenfeld wikiPageWikiLink Bacteriology.
- Gastão_Rosenfeld wikiPageWikiLink Biochemistry.
- Gastão_Rosenfeld wikiPageWikiLink Biomedical_scientist.
- Gastão_Rosenfeld wikiPageWikiLink Blood.
- Gastão_Rosenfeld wikiPageWikiLink Blood_plasma.
- Gastão_Rosenfeld wikiPageWikiLink Bothrops.
- Gastão_Rosenfeld wikiPageWikiLink Bradykinin.
- Gastão_Rosenfeld wikiPageWikiLink Brazil.
- Gastão_Rosenfeld wikiPageWikiLink Bristol-Myers_Squibb.
- Gastão_Rosenfeld wikiPageWikiLink Budapest.
- Gastão_Rosenfeld wikiPageWikiLink Captopril.
- Gastão_Rosenfeld wikiPageWikiLink Category:1912_births.
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- Gastão_Rosenfeld wikiPageWikiLink Chronic_leukemia.
- Gastão_Rosenfeld wikiPageWikiLink Coagulation.
- Gastão_Rosenfeld wikiPageWikiLink Endogeny_(biology).
- Gastão_Rosenfeld wikiPageWikiLink Envenomation.
- Gastão_Rosenfeld wikiPageWikiLink Eva_Maria_Antonia_Kelen.
- Gastão_Rosenfeld wikiPageWikiLink Fibrinolysis.
- Gastão_Rosenfeld wikiPageWikiLink Giemsa_stain.
- Gastão_Rosenfeld wikiPageWikiLink Hematology.
- Gastão_Rosenfeld wikiPageWikiLink Hementerin.
- Gastão_Rosenfeld wikiPageWikiLink Hospital.
- Gastão_Rosenfeld wikiPageWikiLink Hospital_Vital_Brazil.
- Gastão_Rosenfeld wikiPageWikiLink Hungary.
- Gastão_Rosenfeld wikiPageWikiLink Hypotension.
- Gastão_Rosenfeld wikiPageWikiLink Instituto_Biológico.
- Gastão_Rosenfeld wikiPageWikiLink Instituto_Butantan.
- Gastão_Rosenfeld wikiPageWikiLink Instituto_Moreira_Salles.
- Gastão_Rosenfeld wikiPageWikiLink Jews.
- Gastão_Rosenfeld wikiPageWikiLink Kinin.
- Gastão_Rosenfeld wikiPageWikiLink Leech.
- Gastão_Rosenfeld wikiPageWikiLink Maurício_Rocha_e_Silva.
- Gastão_Rosenfeld wikiPageWikiLink May–Grunwald.
- Gastão_Rosenfeld wikiPageWikiLink Medicine.
- Gastão_Rosenfeld wikiPageWikiLink Metabolism.
- Gastão_Rosenfeld wikiPageWikiLink Pathophysiology.
- Gastão_Rosenfeld wikiPageWikiLink Peptide.
- Gastão_Rosenfeld wikiPageWikiLink Pharmacology.
- Gastão_Rosenfeld wikiPageWikiLink Photographer.
- Gastão_Rosenfeld wikiPageWikiLink Physician.
- Gastão_Rosenfeld wikiPageWikiLink Physiology.
- Gastão_Rosenfeld wikiPageWikiLink Protease.
- Gastão_Rosenfeld wikiPageWikiLink Public_domain.
- Gastão_Rosenfeld wikiPageWikiLink Rosenfeld_staining.
- Gastão_Rosenfeld wikiPageWikiLink Royalty_payment.
- Gastão_Rosenfeld wikiPageWikiLink Scientific_leader.
- Gastão_Rosenfeld wikiPageWikiLink Scientific_method.
- Gastão_Rosenfeld wikiPageWikiLink Shock_(circulatory).
- Gastão_Rosenfeld wikiPageWikiLink Snake.
- Gastão_Rosenfeld wikiPageWikiLink Sociedade_Brasileira_para_o_Progresso_da_Ciência.
- Gastão_Rosenfeld wikiPageWikiLink Staining.
- Gastão_Rosenfeld wikiPageWikiLink Symptom.
- Gastão_Rosenfeld wikiPageWikiLink São_Paulo.
- Gastão_Rosenfeld wikiPageWikiLink Sérgio_Henrique_Ferreira.
- Gastão_Rosenfeld wikiPageWikiLink Therapy.
- Gastão_Rosenfeld wikiPageWikiLink Toxicology.
- Gastão_Rosenfeld wikiPageWikiLink Toxin.
- Gastão_Rosenfeld wikiPageWikiLink Venom.
- Gastão_Rosenfeld wikiPageWikiLink Vital_Brazil.
- Gastão_Rosenfeld wikiPageWikiLink William_Otto_Bier.
- Gastão_Rosenfeld wikiPageWikiLink Wilson_Teixeira_Beraldo.
- Gastão_Rosenfeld wikiPageWikiLinkText "Gastão Rosenfeld".
- Gastão_Rosenfeld wikiPageUsesTemplate Template:Reflist.
- Gastão_Rosenfeld subject Category:1912_births.
- Gastão_Rosenfeld subject Category:1990_deaths.
- Gastão_Rosenfeld subject Category:Austro-Hungarian_emigrants_to_Brazil.
- Gastão_Rosenfeld subject Category:Brazilian_Jews.
- Gastão_Rosenfeld subject Category:Brazilian_people_of_Hungarian-Jewish_descent.
- Gastão_Rosenfeld subject Category:Brazilian_scientists.
- Gastão_Rosenfeld subject Category:Hungarian_Jews.
- Gastão_Rosenfeld subject Category:Jewish_scientists.
- Gastão_Rosenfeld hypernym Physician.
- Gastão_Rosenfeld type Person.
- Gastão_Rosenfeld type Scientist.
- Gastão_Rosenfeld type Diacritic.
- Gastão_Rosenfeld type Redirect.
- Gastão_Rosenfeld type Scholar.
- Gastão_Rosenfeld type Scientist.
- Gastão_Rosenfeld comment "Gastão Rosenfeld (born Budapest, July 26, 1912; died São Paulo, July 15, 1990), was a Brazilian physician and biomedical scientist, one of the co-discoverers of bradykinin, together with Maurício Rocha e Silva and Wilson Teixeira Beraldo, in 1949.Rosenfeld was born in 1912 in Budapest, Hungary, to a family of Jewish origin, and came with his parents to Brazil in 1913, graduating in medicine in 1938. Since 1932, he began to devote himself to Hematology.".