Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Gaboxadol> ?p ?o }
- Gaboxadol abstract "Gaboxadol, also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a conformationally constrained derivative of the alkaloid muscimol that was first synthesized in 1977 by the Danish chemist Povl Krogsgaard-Larsen. In the early 1980s gaboxadol was the subject of a series of pilot studies that tested its efficacy as an analgesic and anxiolytic, as well as a treatment for tardive dyskinesia, Huntington's disease, Alzheimer's disease, and spasticity. It was not until 1996 that researchers attempted to harness gaboxadol's frequently reported sedative \"adverse effect\" for the treatment of insomnia, resulting in a series of clinical trials sponsored by Lundbeck and Merck. In March, 2007, Merck and Lundbeck cancelled work on the drug, citing safety concerns and the failure of an efficacy trial. It acts on the GABA system, but possibly in a different way from benzodiazepines, Z-Drugs and barbiturates. Lundbeck states that gaboxadol also increases deep sleep (stage 4). It is, however, not reinforcing like benzodiazepines are.In 2015, Lundbeck sold its rights to the molecule to Ovid Therapeutics, whose plan is to develop it for FXS and Angelman Syndrome.".
- Gaboxadol atcPrefix "none".
- Gaboxadol casNumber "64603-91-4".
- Gaboxadol fdaUniiCode "K1M5RVL18S".
- Gaboxadol iupacName "4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one".
- Gaboxadol pubchem "3448".
- Gaboxadol thumbnail Gaboxadol.svg?width=300.
- Gaboxadol wikiPageExternalLink gaboxadol.
- Gaboxadol wikiPageExternalLink www.lundbeck.com.
- Gaboxadol wikiPageExternalLink medicalnews.php?newsid=55678.
- Gaboxadol wikiPageExternalLink 29sleep.html?ref=health.
- Gaboxadol wikiPageID "9891425".
- Gaboxadol wikiPageLength "5023".
- Gaboxadol wikiPageOutDegree "28".
- Gaboxadol wikiPageRevisionID "693295731".
- Gaboxadol wikiPageWikiLink Adverse_effect.
- Gaboxadol wikiPageWikiLink Alkaloid.
- Gaboxadol wikiPageWikiLink Alzheimers_disease.
- Gaboxadol wikiPageWikiLink Amanita_muscaria.
- Gaboxadol wikiPageWikiLink Angelman_syndrome.
- Gaboxadol wikiPageWikiLink Barbiturate.
- Gaboxadol wikiPageWikiLink Benzodiazepine.
- Gaboxadol wikiPageWikiLink Category:Anticonvulsants.
- Gaboxadol wikiPageWikiLink Category:Danish_inventions.
- Gaboxadol wikiPageWikiLink Category:GABAA-rho_receptor_antagonists.
- Gaboxadol wikiPageWikiLink Category:GABAA_receptor_agonists.
- Gaboxadol wikiPageWikiLink Category:Glycine_receptor_antagonists.
- Gaboxadol wikiPageWikiLink Category:Isoxazolidinones.
- Gaboxadol wikiPageWikiLink Category:Lactams.
- Gaboxadol wikiPageWikiLink Category:Sedatives.
- Gaboxadol wikiPageWikiLink Chemist.
- Gaboxadol wikiPageWikiLink Fragile_X_syndrome.
- Gaboxadol wikiPageWikiLink Gamma-Aminobutyric_acid.
- Gaboxadol wikiPageWikiLink Huntingtons_disease.
- Gaboxadol wikiPageWikiLink Lundbeck.
- Gaboxadol wikiPageWikiLink Merck_&_Co..
- Gaboxadol wikiPageWikiLink Muscimol.
- Gaboxadol wikiPageWikiLink Non-rapid_eye_movement_sleep.
- Gaboxadol wikiPageWikiLink Nonbenzodiazepine.
- Gaboxadol wikiPageWikiLink Pilot_experiment.
- Gaboxadol wikiPageWikiLink Spasticity.
- Gaboxadol wikiPageWikiLink Tardive_dyskinesia.
- Gaboxadol wikiPageWikiLinkText "Gaboxadol".
- Gaboxadol wikiPageWikiLinkText "gaboxadol".
- Gaboxadol atcPrefix "none".
- Gaboxadol c "6".
- Gaboxadol casNumber "64603".
- Gaboxadol chembl "312443".
- Gaboxadol chemspiderid "3330".
- Gaboxadol h "8".
- Gaboxadol inchi "1".
- Gaboxadol inchikey "ZXRVKCBLGJOCEE-UHFFFAOYAU".
- Gaboxadol iupacName "4567".
- Gaboxadol iupharLigand "4322".
- Gaboxadol kegg "D04282".
- Gaboxadol molecularWeight "140.14".
- Gaboxadol n "2".
- Gaboxadol o "2".
- Gaboxadol pubchem "3448".
- Gaboxadol smiles "O=C1/C2=CCNCC2".
- Gaboxadol stdinchi "1".
- Gaboxadol stdinchikey "ZXRVKCBLGJOCEE-UHFFFAOYSA-N".
- Gaboxadol unii "K1M5RVL18S".
- Gaboxadol verifiedfields "changed".
- Gaboxadol verifiedrevid "457288866".
- Gaboxadol wikiPageUsesTemplate Template:Cascite.
- Gaboxadol wikiPageUsesTemplate Template:Chemspidercite.
- Gaboxadol wikiPageUsesTemplate Template:Drugbankcite.
- Gaboxadol wikiPageUsesTemplate Template:Drugbox.
- Gaboxadol wikiPageUsesTemplate Template:Ebicite.
- Gaboxadol wikiPageUsesTemplate Template:Fdacite.
- Gaboxadol wikiPageUsesTemplate Template:GABAergics.
- Gaboxadol wikiPageUsesTemplate Template:Glycinergics.
- Gaboxadol wikiPageUsesTemplate Template:Hypnotics_and_sedatives.
- Gaboxadol wikiPageUsesTemplate Template:Keggcite.
- Gaboxadol wikiPageUsesTemplate Template:MeshName.
- Gaboxadol wikiPageUsesTemplate Template:Reflist.
- Gaboxadol wikiPageUsesTemplate Template:Sedative-stub.
- Gaboxadol wikiPageUsesTemplate Template:Stdinchicite.
- Gaboxadol subject Category:Anticonvulsants.
- Gaboxadol subject Category:Danish_inventions.
- Gaboxadol subject Category:GABAA-rho_receptor_antagonists.
- Gaboxadol subject Category:GABAA_receptor_agonists.
- Gaboxadol subject Category:Glycine_receptor_antagonists.
- Gaboxadol subject Category:Isoxazolidinones.
- Gaboxadol subject Category:Lactams.
- Gaboxadol subject Category:Sedatives.
- Gaboxadol type ChemicalSubstance.
- Gaboxadol type Drug.
- Gaboxadol type Agonist.
- Gaboxadol type Amide.
- Gaboxadol type Chemical.
- Gaboxadol type Drug.
- Gaboxadol type Heterocycle.
- Gaboxadol type Lactam.
- Gaboxadol type ChemicalObject.
- Gaboxadol type Thing.
- Gaboxadol type Q8386.
- Gaboxadol comment "Gaboxadol, also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a conformationally constrained derivative of the alkaloid muscimol that was first synthesized in 1977 by the Danish chemist Povl Krogsgaard-Larsen. In the early 1980s gaboxadol was the subject of a series of pilot studies that tested its efficacy as an analgesic and anxiolytic, as well as a treatment for tardive dyskinesia, Huntington's disease, Alzheimer's disease, and spasticity.".
- Gaboxadol label "Gaboxadol".