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- Gabapentinoid abstract "Gabapentinoids are 3-substituted derivatives of the neurotransmitter γ-aminobutyric acid (GABA) which block α2δ subunit-containing voltage-dependent calcium channels (VDCCs). Clinically-used gabapentinoids include gabapentin (Neurontin) and pregabalin (Lyrica), as well as a gabapentin prodrug, gabapentin enacarbil (Horizant). Another analogue mirogabalin is in clinical trials but has not yet been approved. Other compounds from this family used in research but not developed for medical use include atagabalin, 4-methylpregabalin and PD-217,014. Gabapentinoids are used clinically in the treatment of conditions including epilepsy, neuropathic pain, fibromyalgia, anxiety, and restless legs syndrome, among others.Recently, phenibut (β-phenyl-GABA), a close analogue of pregabalin (β-isobutyl-GABA), has been found to similarly bind to and block α2δ-containing VDCCs, notably with an affinity exceeding that of its other actions, effectively making it a gabapentinoid. Baclofen (β-(4-chlorophenyl)-GABA) has also been found to do this, but extremely weakly and likely insignificantly relative to its primary action of activation of the GABAB receptor.".
- Gabapentinoid wikiPageID "43348559".
- Gabapentinoid wikiPageLength "4428".
- Gabapentinoid wikiPageOutDegree "28".
- Gabapentinoid wikiPageRevisionID "700202188".
- Gabapentinoid wikiPageWikiLink 4-Methylpregabalin.
- Gabapentinoid wikiPageWikiLink Anxiety.
- Gabapentinoid wikiPageWikiLink Atagabalin.
- Gabapentinoid wikiPageWikiLink Baclofen.
- Gabapentinoid wikiPageWikiLink Category:Amino_acids.
- Gabapentinoid wikiPageWikiLink Category:Analgesics.
- Gabapentinoid wikiPageWikiLink Category:Anticonvulsants.
- Gabapentinoid wikiPageWikiLink Category:Anxiolytics.
- Gabapentinoid wikiPageWikiLink Category:GABA_analogues.
- Gabapentinoid wikiPageWikiLink Epilepsy.
- Gabapentinoid wikiPageWikiLink Fibromyalgia.
- Gabapentinoid wikiPageWikiLink GABAB_receptor.
- Gabapentinoid wikiPageWikiLink GABA_analogue.
- Gabapentinoid wikiPageWikiLink GABAergic.
- Gabapentinoid wikiPageWikiLink Gabapentin.
- Gabapentinoid wikiPageWikiLink Gabapentin_enacarbil.
- Gabapentinoid wikiPageWikiLink Gamma-Aminobutyric_acid.
- Gabapentinoid wikiPageWikiLink Ligand_(biochemistry).
- Gabapentinoid wikiPageWikiLink Mirogabalin.
- Gabapentinoid wikiPageWikiLink Neuropathic_pain.
- Gabapentinoid wikiPageWikiLink Neurotransmitter.
- Gabapentinoid wikiPageWikiLink PD-217,014.
- Gabapentinoid wikiPageWikiLink Phenibut.
- Gabapentinoid wikiPageWikiLink Pregabalin.
- Gabapentinoid wikiPageWikiLink Prodrug.
- Gabapentinoid wikiPageWikiLink Restless_legs_syndrome.
- Gabapentinoid wikiPageWikiLink Voltage-dependent_calcium_channel.
- Gabapentinoid wikiPageWikiLinkText "Gabapentinoid".
- Gabapentinoid wikiPageWikiLinkText "gabapentinoid".
- Gabapentinoid wikiPageUsesTemplate Template:Anticonvulsants.
- Gabapentinoid wikiPageUsesTemplate Template:Anxiolytics.
- Gabapentinoid wikiPageUsesTemplate Template:Channel_blockers.
- Gabapentinoid wikiPageUsesTemplate Template:Drug_use.
- Gabapentinoid wikiPageUsesTemplate Template:GABAergics.
- Gabapentinoid wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- Gabapentinoid wikiPageUsesTemplate Template:Neuropathic_pain_and_fibromyalgia_pharmacotherapies.
- Gabapentinoid wikiPageUsesTemplate Template:Reflist.
- Gabapentinoid subject Category:Amino_acids.
- Gabapentinoid subject Category:Analgesics.
- Gabapentinoid subject Category:Anticonvulsants.
- Gabapentinoid subject Category:Anxiolytics.
- Gabapentinoid subject Category:GABA_analogues.
- Gabapentinoid hypernym Derivatives.
- Gabapentinoid type ChemicalCompound.
- Gabapentinoid comment "Gabapentinoids are 3-substituted derivatives of the neurotransmitter γ-aminobutyric acid (GABA) which block α2δ subunit-containing voltage-dependent calcium channels (VDCCs). Clinically-used gabapentinoids include gabapentin (Neurontin) and pregabalin (Lyrica), as well as a gabapentin prodrug, gabapentin enacarbil (Horizant). Another analogue mirogabalin is in clinical trials but has not yet been approved.".
- Gabapentinoid label "Gabapentinoid".
- Gabapentinoid sameAs Q18207292.
- Gabapentinoid sameAs m.011c9c7t.
- Gabapentinoid sameAs Q18207292.
- Gabapentinoid wasDerivedFrom Gabapentinoid?oldid=700202188.
- Gabapentinoid isPrimaryTopicOf Gabapentinoid.