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- GSK-189,254 abstract "GSK-189,254 is a potent and selective H3 histamine receptor inverse agonist developed by GlaxoSmithKline. It has subnanomolar affinity for the H3 receptor (Ki = 0.2nM) and selectivity of over 10,000x for H3 over other histamine receptor subtypes. Animal studies have shown it to possess not only stimulant and nootropic effects, but also analgesic action suggesting a role for H3 receptors in pain processing in the spinal cord. GSK-189,254 and several other related drugs are currently being investigated as a treatment for Alzheimer's disease and other forms of dementia, as well as possible use in the treatment of conditions such as narcolepsy, or neuropathic pain which do not respond well to conventional analgesic drugs.".
- GSK-189,254 iupacName "6-[(3-cyclobutyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)oxy]-N-methylpyridine-3-carboxamide".
- GSK-189,254 pubchem "9798547".
- GSK-189,254 thumbnail GSK-189,254.svg?width=300.
- GSK-189,254 wikiPageID "19209465".
- GSK-189,254 wikiPageLength "4738".
- GSK-189,254 wikiPageOutDegree "18".
- GSK-189,254 wikiPageRevisionID "706506323".
- GSK-189,254 wikiPageWikiLink Alzheimers_disease.
- GSK-189,254 wikiPageWikiLink Analgesic.
- GSK-189,254 wikiPageWikiLink Category:Benzazepines.
- GSK-189,254 wikiPageWikiLink Category:Carboxamides.
- GSK-189,254 wikiPageWikiLink Category:GlaxoSmithKline.
- GSK-189,254 wikiPageWikiLink Category:H3_receptor_antagonists.
- GSK-189,254 wikiPageWikiLink Category:Nootropics.
- GSK-189,254 wikiPageWikiLink Category:Phenol_ethers.
- GSK-189,254 wikiPageWikiLink Category:Pyridines.
- GSK-189,254 wikiPageWikiLink Dementia.
- GSK-189,254 wikiPageWikiLink Dissociation_constant.
- GSK-189,254 wikiPageWikiLink GlaxoSmithKline.
- GSK-189,254 wikiPageWikiLink Histamine_H3_receptor.
- GSK-189,254 wikiPageWikiLink Inverse_agonist.
- GSK-189,254 wikiPageWikiLink Narcolepsy.
- GSK-189,254 wikiPageWikiLink Neuropathic_pain.
- GSK-189,254 wikiPageWikiLink Nootropic.
- GSK-189,254 wikiPageWikiLink Stimulant.
- GSK-189,254 wikiPageWikiLinkText "GSK-189,254".
- GSK-189,254 c "21".
- GSK-189,254 chembl "517140".
- GSK-189,254 chemspiderid "7974313".
- GSK-189,254 h "25".
- GSK-189,254 inchi "1".
- GSK-189,254 inchikey "WROHEWWOCPRMIA-UHFFFAOYAZ".
- GSK-189,254 iupacName "6".
- GSK-189,254 molecularWeight "351.441".
- GSK-189,254 n "3".
- GSK-189,254 o "2".
- GSK-189,254 pubchem "9798547".
- GSK-189,254 smiles "c4cc1CCNCCc1cc4Ocncc2CNC".
- GSK-189,254 stdinchi "1".
- GSK-189,254 stdinchikey "WROHEWWOCPRMIA-UHFFFAOYSA-N".
- GSK-189,254 verifiedfields "changed".
- GSK-189,254 verifiedrevid "449551934".
- GSK-189,254 width "240".
- GSK-189,254 wikiPageUsesTemplate Template:Chemspidercite.
- GSK-189,254 wikiPageUsesTemplate Template:Drugbox.
- GSK-189,254 wikiPageUsesTemplate Template:Ebicite.
- GSK-189,254 wikiPageUsesTemplate Template:Histaminergics.
- GSK-189,254 wikiPageUsesTemplate Template:Nootropics.
- GSK-189,254 wikiPageUsesTemplate Template:Stdinchicite.
- GSK-189,254 subject Category:Benzazepines.
- GSK-189,254 subject Category:Carboxamides.
- GSK-189,254 subject Category:GlaxoSmithKline.
- GSK-189,254 subject Category:H3_receptor_antagonists.
- GSK-189,254 subject Category:Nootropics.
- GSK-189,254 subject Category:Phenol_ethers.
- GSK-189,254 subject Category:Pyridines.
- GSK-189,254 hypernym Agonist.
- GSK-189,254 type ChemicalSubstance.
- GSK-189,254 type Company.
- GSK-189,254 type Drug.
- GSK-189,254 type Group.
- GSK-189,254 type Amide.
- GSK-189,254 type Antagonist.
- GSK-189,254 type Antihistamine.
- GSK-189,254 type Chemical.
- GSK-189,254 type Company.
- GSK-189,254 type Ether.
- GSK-189,254 type Group.
- GSK-189,254 type Heterocycle.
- GSK-189,254 type Nootropic.
- GSK-189,254 type Psychoanaleptic.
- GSK-189,254 type ChemicalObject.
- GSK-189,254 type Thing.
- GSK-189,254 type Q8386.
- GSK-189,254 comment "GSK-189,254 is a potent and selective H3 histamine receptor inverse agonist developed by GlaxoSmithKline. It has subnanomolar affinity for the H3 receptor (Ki = 0.2nM) and selectivity of over 10,000x for H3 over other histamine receptor subtypes. Animal studies have shown it to possess not only stimulant and nootropic effects, but also analgesic action suggesting a role for H3 receptors in pain processing in the spinal cord.".
- GSK-189,254 label "GSK-189,254".
- GSK-189,254 sameAs Q5514566.
- GSK-189,254 sameAs m.04lf02j.
- GSK-189,254 sameAs GSK-189,254.
- GSK-189,254 sameAs GSK-189,254.
- GSK-189,254 sameAs Q5514566.
- GSK-189,254 wasDerivedFrom GSK-189,254?oldid=706506323.
- GSK-189,254 depiction GSK-189,254.svg.
- GSK-189,254 isPrimaryTopicOf GSK-189,254.