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- GPNMB abstract "Transmembrane glycoprotein NMB is a protein that in humans is encoded by the GPNMB gene. The mouse and rat orthologues of GPNMB are known as DC-HIL and Osteoactivin (OA), respectively. Two transcript variants encoding 560 and 572 amino acid isoforms have been characterized for this gene in humans. GPNMB is a type I transmembrane glycoprotein which shows homology to the pmel17 precursor, a melanocyte-specific protein.GPNMB has been reported to be expressed in various cell types, including: melanocytes, osteoclasts, osteoblasts, dendritic cells, and it is overexpressed in various cancer types. In melanocytic cells and osteoclasts the GPNMB gene is transcritionally regulated by Microphthalmia-associated transcription factor. In osteoblast progenitor cells, Osteoactivin works as a positive regulator of osteoblast differentiation during later stages of matrix maturation and mineralization that is mediated at least in part by BMP-2 in a SMAD1 dependent manner to promote osteoblast differentiation. In addition, using a rat fracture model, Osteoactivin (OA) enhances the repairing process in bone fracture, demonstrated by its high expression during chondrogenesis (soft callus) and osteogenesis (hard callus) compared to the intact femurs that is why Osteoactivin (OA) could be a novel therapeutic agent used to treat generalized osteoporosis or localized osteopenia during fracture repair by stimulating bone growth and regeneration. Similarly, Osteoactivin expression increases during osteoclast differentiation and it is functionally implicated in this process, possibly by promoting the fusion of osteoclast progenitor cells.".
- GPNMB entrezgene "10457".
- GPNMB wikiPageExternalLink pmidlookup?view=long&pmid=12176896.
- GPNMB wikiPageExternalLink pmidlookup?view=long&pmid=9847074.
- GPNMB wikiPageExternalLink abstract.php?id=1468.
- GPNMB wikiPageID "14794357".
- GPNMB wikiPageLength "16412".
- GPNMB wikiPageOutDegree "28".
- GPNMB wikiPageRevisionID "676856746".
- GPNMB wikiPageWikiLink Antibody-drug_conjugate.
- GPNMB wikiPageWikiLink BMP-2.
- GPNMB wikiPageWikiLink Breast_cancer.
- GPNMB wikiPageWikiLink Cell_migration.
- GPNMB wikiPageWikiLink Chondrogenesis.
- GPNMB wikiPageWikiLink Epithelium.
- GPNMB wikiPageWikiLink Gene.
- GPNMB wikiPageWikiLink Glembatumumab_vedotin.
- GPNMB wikiPageWikiLink Glioma.
- GPNMB wikiPageWikiLink Glycoprotein.
- GPNMB wikiPageWikiLink Immunohistochemistry.
- GPNMB wikiPageWikiLink Melanocyte.
- GPNMB wikiPageWikiLink Melanoma.
- GPNMB wikiPageWikiLink Metastasis.
- GPNMB wikiPageWikiLink Microphthalmia-associated_transcription_factor.
- GPNMB wikiPageWikiLink Monomethyl_auristatin_E.
- GPNMB wikiPageWikiLink Mothers_against_decapentaplegic_homolog_1.
- GPNMB wikiPageWikiLink Neoplasm.
- GPNMB wikiPageWikiLink Ossification.
- GPNMB wikiPageWikiLink Osteoporosis.
- GPNMB wikiPageWikiLink PMEL_(gene).
- GPNMB wikiPageWikiLink Protein.
- GPNMB wikiPageWikiLink Stroma_(animal_tissue).
- GPNMB wikiPageWikiLink Transmembrane_protein.
- GPNMB wikiPageWikiLink Triple-negative_breast_cancer.
- GPNMB wikiPageWikiLinkText "GPNMB".
- GPNMB wikiPageUsesTemplate Template:Cite_journal.
- GPNMB wikiPageUsesTemplate Template:PBB.
- GPNMB wikiPageUsesTemplate Template:Refbegin.
- GPNMB wikiPageUsesTemplate Template:Refend.
- GPNMB wikiPageUsesTemplate Template:Reflist.
- GPNMB hypernym Protein.
- GPNMB type Biomolecule.
- GPNMB type Protein.
- GPNMB type Page.
- GPNMB type Thing.
- GPNMB type Q206229.
- GPNMB type Q8054.
- GPNMB comment "Transmembrane glycoprotein NMB is a protein that in humans is encoded by the GPNMB gene. The mouse and rat orthologues of GPNMB are known as DC-HIL and Osteoactivin (OA), respectively. Two transcript variants encoding 560 and 572 amino acid isoforms have been characterized for this gene in humans.".
- GPNMB label "GPNMB".
- GPNMB sameAs Q18035399.
- GPNMB sameAs m.03gy4n4.
- GPNMB sameAs Q18035399.
- GPNMB wasDerivedFrom GPNMB?oldid=676856746.
- GPNMB isPrimaryTopicOf GPNMB.