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- GCM_transcription_factors abstract "In molecular biology, the GCM transcription factors are a family of proteins which contain a GCM motif. The GCM motif is a domain that has been identified in proteins belonging to a family of transcriptional regulators involved in fundamental developmental processes which comprise Drosophila melanogaster GCM and its mammalian homologues. In GCM transcription factors the N-terminal moiety contains a DNA-binding domain of 150 amino acids. Sequence conservation is highest in this GCM domain. In contrast, the C-terminal moiety contains one or two transactivating regions and is only poorly conserved.The GCM motif has been shown to be a DNA binding domain that recognises preferentially the nonpalindromic octamer 5'-ATGCGGGT-3'. The GCM motif contains many conserved basic amino acid residues, seven cysteine residues, and four histidine residues. The conserved cysteines are involved in shaping the overall conformation of the domain, in the process of DNA binding and in the redox regulation of DNA binding. The GCM domain as a new class of Zn-containing DNA-binding domain with no similarity to any other DNA-binding domain. The GCM domain consists of a large and a small domain tethered together by one of the two Zn ions present in the structure. The large and the small domains comprise five- and three-stranded beta-sheets, respectively, with three small helical segments packed against the same side of the two beta-sheets. The GCM domain exercises a novel mode of sequence-specific DNA recognition, where the five-stranded beta-pleated sheet inserts into the major groove of the DNA. Residues protruding from the edge strand of the beta-pleated sheet and the following loop and strand contact the bases and backbone of both DNA strands, providing specificity for its DNA target site.".
- GCM_transcription_factors symbol "GCM".
- GCM_transcription_factors thumbnail PDB_1odh_EBI.jpg?width=300.
- GCM_transcription_factors wikiPageID "32955012".
- GCM_transcription_factors wikiPageLength "4491".
- GCM_transcription_factors wikiPageOutDegree "30".
- GCM_transcription_factors wikiPageRevisionID "607876886".
- GCM_transcription_factors wikiPageWikiLink Amino_acid.
- GCM_transcription_factors wikiPageWikiLink Beta_sheet.
- GCM_transcription_factors wikiPageWikiLink Biomolecular_structure.
- GCM_transcription_factors wikiPageWikiLink C-terminus.
- GCM_transcription_factors wikiPageWikiLink Category:Protein_families.
- GCM_transcription_factors wikiPageWikiLink Conserved_sequence.
- GCM_transcription_factors wikiPageWikiLink Cysteine.
- GCM_transcription_factors wikiPageWikiLink DNA.
- GCM_transcription_factors wikiPageWikiLink Drosophila_melanogaster.
- GCM_transcription_factors wikiPageWikiLink Helix.
- GCM_transcription_factors wikiPageWikiLink Histidine.
- GCM_transcription_factors wikiPageWikiLink Ion.
- GCM_transcription_factors wikiPageWikiLink Mammal.
- GCM_transcription_factors wikiPageWikiLink N-terminus.
- GCM_transcription_factors wikiPageWikiLink Nucleic_acid_double_helix.
- GCM_transcription_factors wikiPageWikiLink Nucleotide.
- GCM_transcription_factors wikiPageWikiLink Palindrome.
- GCM_transcription_factors wikiPageWikiLink Protein.
- GCM_transcription_factors wikiPageWikiLink Protein_domain.
- GCM_transcription_factors wikiPageWikiLink Protein_family.
- GCM_transcription_factors wikiPageWikiLink Redox.
- GCM_transcription_factors wikiPageWikiLink Regulation_of_gene_expression.
- GCM_transcription_factors wikiPageWikiLink Sequence_motif.
- GCM_transcription_factors wikiPageWikiLink Transcription_factor.
- GCM_transcription_factors wikiPageWikiLink Turn_(biochemistry).
- GCM_transcription_factors wikiPageWikiLink Zinc.
- GCM_transcription_factors wikiPageWikiLinkText "GCM motif".
- GCM_transcription_factors caption "structure of the gcm domain bound to dna".
- GCM_transcription_factors interpro "IPR003902".
- GCM_transcription_factors name "GCM".
- GCM_transcription_factors pfam "PF03615".
- GCM_transcription_factors pfamClan "CL0274".
- GCM_transcription_factors scop "1".
- GCM_transcription_factors symbol "GCM".
- GCM_transcription_factors wikiPageUsesTemplate Template:Infobox_protein_family.
- GCM_transcription_factors wikiPageUsesTemplate Template:InterPro_content.
- GCM_transcription_factors wikiPageUsesTemplate Template:Reflist.
- GCM_transcription_factors subject Category:Protein_families.
- GCM_transcription_factors hypernym Family.
- GCM_transcription_factors type Biomolecule.
- GCM_transcription_factors type Protein.
- GCM_transcription_factors type Chemical.
- GCM_transcription_factors type Thing.
- GCM_transcription_factors type Q206229.
- GCM_transcription_factors type Q8054.
- GCM_transcription_factors comment "In molecular biology, the GCM transcription factors are a family of proteins which contain a GCM motif. The GCM motif is a domain that has been identified in proteins belonging to a family of transcriptional regulators involved in fundamental developmental processes which comprise Drosophila melanogaster GCM and its mammalian homologues. In GCM transcription factors the N-terminal moiety contains a DNA-binding domain of 150 amino acids. Sequence conservation is highest in this GCM domain.".
- GCM_transcription_factors label "GCM transcription factors".
- GCM_transcription_factors sameAs Q5513004.
- GCM_transcription_factors sameAs m.0h53_lm.
- GCM_transcription_factors sameAs Q5513004.
- GCM_transcription_factors wasDerivedFrom GCM_transcription_factors?oldid=607876886.
- GCM_transcription_factors depiction PDB_1odh_EBI.jpg.
- GCM_transcription_factors isPrimaryTopicOf GCM_transcription_factors.